Hartl, Brad A Ma, Htet S W Hansen, Katherine S Perks, Julian Kent, Michael S Fragoso, Ruben C Marcu, Laura
Published in
International journal of radiation biology
To provide a comprehensive understanding of how the selection of radiation dose affects the temporal and spatial progression of radiation-induced necrosis in the rat model. Necrosis was induced with a single fraction of radiation exposure, at doses ranging between 20 and 60 Gy, to the right hemisphere of 8-week-old Fischer rats from a linear accele...
Ng, Enoch Browne, Caleb J Samsom, James N Wong, Albert H C
Published in
The American journal of drug and alcohol abuse
Depression and substance use disorders are often comorbid, but the reasons for this are unclear. In human studies, it is difficult to determine how one disorder may affect predisposition to the other and what the underlying mechanisms might be. Instead, animal studies allow experimental induction of behaviors relevant to depression and drug-taking,...
Snider, Silvia Cavalli, Andrea Colombo, Francesca Gallotti, Alberto Luigi Quattrini, Angelo Salvatore, Luca Madaghiele, Marta Terreni, Maria Rosa Sannino, Alessandro Mortini, Pietro
...
Published in
Journal of biomedical materials research. Part B, Applied biomaterials
Traumatic spinal cord injury (SCI) is a damage to the spinal cord that results in loss or impaired motor and/or sensory function. SCI is a sudden and unexpected event characterized by high morbidity and mortality rate during both acute and chronic stages, and it can be devastating in human, social and economical terms. Despite significant progresse...
Barrientos, G Pussetto, M Rose, M Staff, A C Blois, S M Toblli, J E
Published in
Molecular human reproduction
What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular inju...
Medina, Marcela Fátima Arrieta, María Celeste Villafañe, Marcela Noemí Klyver, Sandra María Roxana Odstrcil, Iris María Aybar González, María Elina
Published in
Toxicology and industrial health
The cadmium (Cd) concentration in the environment has increased as a consequence of anthropogenic activity. The objective of this study was to determine early signs of Cd toxicity in testes and sperm as possible biomarkers. The dose orally administered to Wistar rats was within the range where chronic toxicity can appear. At the light microscopic l...
Thangarajah, Tanujan Henshaw, Frederick Sanghani-Kerai, Anita Lambert, Simon M Pendegrass, Catherine J Blunn, Gordon W
Published in
Shoulder & elbow
To evaluate biological strategies that enhance tendon-bone healing in humans, it is imperative that suitable animal models accurately reproduce the pathological changes observed in the clinical setting following a tear. The purpose of the present study was to investigate rotator cuff degeneration in a rat, as well as assess the development of osteo...
Singh, Vijay K Olabisi, Ayodele O
Published in
Expert opinion on drug discovery
Despite significant scientific advances over the past six decades toward the development of safe and effective radiation countermeasures for humans using animal models, only two pharmaceutical agents have been approved by United States Food and Drug Administration (US FDA) for hematopoietic acute radiation syndrome (H-ARS). Additional research effo...
Dupont, Didier
Our goals :- To understand the mechanisms of breakdown of food matrices and their constituents in the gut and identify the beneficial/deleterious food components released during digestion- To determine the impact of the structure of food matrices on these mechanisms- To model these phenomena in order to develop a reverse engineering approach
Taghiyar, Leila Hesaraki, Mahdi Sayahpour, Forough Azam Satarian, Leila Hosseini, Samaneh Aghdami, Naser Baghaban Eslaminejad, Mohamadreza
Published in
The Journal of biological chemistry
Amputation of the proximal region in mammals is not followed by regeneration because blastema cells (BCs) and expression of regenerative genes, such as Msh homeobox (Msx) genes, are absent in this animal group. The lack of BCs and positional information in other cells is therefore the main obstacle to therapeutic approaches for limb regeneration. H...
Moore, Sarah A Granger, Nicolas Olby, Natasha J Spitzbarth, Ingo Jeffery, Nick D Tipold, Andrea Nout-Lomas, Yvette S da Costa, Ronaldo C Stein, Veronika M Noble-Haeusslein, Linda J
...
Published in
Journal of neurotrauma
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic has been historically challenging, highlighting the need for robust models of injury that more closely mirror the human condition. The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to evaluate expeditiously p...
