Pollard, K. Michael Cauvi, David M. Mayeux, Jessica M. Toomey, Christopher B. Peiss, Amy K. Hultman, Per Kono, Dwight H.
Although numerous environmental exposures have been suggested as triggers for preclinical autoimmunity, only a few have been confidently linked to autoimmune diseases. For disease-associated exposures, the lung is a common site where chronic exposure results in cellular toxicity, tissue damage, inflammation, and fibrosis. These features are exacerb...
Shaheen, Marwa Y. Basudan, Amani M. Niazy, Abdurahman A. van den Beucken, Jeroen J. J. P. Jansen, John A. Alghamdi, Hamdan S.
Published in
Materials
We evaluated the effect of osteoporotic induction after eight weeks of initial healing of bone defects grafted with a xenograft material in a rat model. Bone defects were created in the femoral condyles of 16 female Wistar rats (one defect per rat). The defects were filled with bovine bone (Inter-Oss) granules. After eight weeks of bone healing, ra...
Mohr, Hermine Ballke, Simone Bechmann, Nicole Gulde, Sebastian Malekzadeh-Najafabadi, Jaber Peitzsch, Mirko Ntziachristos, Vasilis Steiger, Katja Wiedemann, Tobias Pellegata, Natalia S.
...
Published in
Cancers
Simple Summary Pheochromocytomas and paragangliomas (PPGLs) can be subdivided into at least three different subgroups associated with different clinical manifestations and depending on the risk to metastasize. A shortage in human tumor material, the lack of a functional human cell line and very limited animal models were major drawbacks for PPGL re...
Potter, Tomos Bassar, Ronald D Bentzen, Paul Ruell, Emily W Torres-Dowdall, Julián Handelsman, Corey A Ghalambor, Cameron K Travis, Joseph Reznick, David N Coulson, Tim
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Published in
The American naturalist
AbstractDetecting contemporary evolution requires demonstrating that genetic change has occurred. Mixed effects models allow estimation of quantitative genetic parameters and are widely used to study evolution in wild populations. However, predictions of evolution based on these parameters frequently fail to match observations. Here, we applied thr...
Ostrin, Lisa A Wildsoet, Christine F
PurposeTo assess the validity of and compare applanation and rebound tonometry readings of intraocular pressure in alert normal chicks from ages 3 to 45 days.MethodsIntraocular pressures (IOPs) were measured weekly in awake White Leghorn chicks, from ages 3-45 days (n = 22-30 per age group), with both applanation Tono-Pen and rebound TonoLab tonome...
Wang, Yi Zhou, Zhiyou Liu, Yang Wang, Zimin Kang, Yifan
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
To investigate the effect of inhibiting transforming growth factor-β (TGF-β1)/Smad2/3 signaling on rotator cuff (RC) healing. A bilateral supraspinatus tendon detachment-repair model of Sprague-Dawley (SD) rats was utilized. A total of 120 SD rats were randomly assigned to six groups and each group received the subacromial injection of normal salin...
Yan, Tianfang Kameda, Seiji Suzuki, Katsuyoshi Kaiju, Taro Inoue, Masato Suzuki, Takafumi Hirata, Masayuki
Published in
Sensors (Basel, Switzerland)
There is a growing interest in the use of electrocorticographic (ECoG) signals in brain–machine interfaces (BMIs). However, there is still a lack of studies involving the long-term evaluation of the tissue response related to electrode implantation. Here, we investigated biocompatibility, including chronic tissue response to subdural electrodes and...
Port, Julia R. Yinda, Claude Kwe Owusu, Irene Offei Holbrook, Myndi Fischer, Robert Bushmaker, Trenton Avanzato, Victoria A. Schulz, Jonathan E. van Doremalen, Neeltje Clancy, Chad S.
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Published in
bioRxiv
Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure presented with distinct disease ...
Wouters, Roxanne Bevers, Sien Riva, Matteo De Smet, Frederik Coosemans, An
Published in
Cancers
Simple Summary Glioblastoma (GBM) remains the most aggressive brain tumor. Treatment typically includes surgery and radio/chemotherapy, but in spite of intensive treatment, virtually all tumors recur within the time-frame of months with insufficient and unsuccessful second line options. This clinical reality is in contrast to preclinical animal exp...
Wouters, Roxanne; Bevers, Sien; Riva, Matteo; 103817; De Smet, Frederik; 44821; Coosemans, An; 52883;
Glioblastoma (GBM) is the most aggressive intrinsic brain tumor in adults. Despite maximal therapy consisting of surgery and radio/chemotherapy, GBM remains largely incurable with a median survival of less than 15 months. GBM has a strong immunosuppressive nature with a multitude of tumor and microenvironment (TME) derived factors that prohibit an ...