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The Modifications of Longevity Regulating Pathway Resulting from Endurance Effort in Arabian Horses

Published in Annals of Animal Science

Recent studies have shown a highly positive effect of physical exercise on the overall condition of the body. The observed changes occur at the cellular level – proliferation, oxidative respiration, ROS degradation, whole-organism homeostasis improvement and ageing inhibition. The longevity regulating pathway is a broad term encompassing all the bi...

Experimental Study on the Time-Dependent Resistance of Open-Ended Steel Piles in Sand

Open-ended steel piles are commonly used as the foundation for offshore structures. Numerous model and field tests have demonstrated a time-dependent increase in the resistance of these piles, a phenomenon referred to as pile ageing or pile setup. Additionally, for open-ended steel piles with comparably small diameters, soil plugging enhances the r...

Balance, Gait, Functionality and Fall Occurrence in Adults and Older Adults with Type 2 Diabetes Mellitus and Associated...

Background: Body balance is regulated by sensory information from the vestibular, visual and somatosensory systems, and changes in one or more of these sensory systems can trigger balance disorders. Individuals with type 2 Diabetes Mellitus (DM2) often present peripheral neuropathy, a condition that alters foot sensory information and can negativel...

Phospholipid Scramblase Activity of VDAC Dimers: New Implications for Cell Death, Autophagy and Ageing

Voltage-dependent anion channels (VDACs) are important proteins of the outer mitochondrial membrane (OMM). Their beta-barrel structure allows for efficient metabolite exchange between the cytosol and mitochondria. VDACs have further been implicated in the control of regulated cell death. Historically, VDACs have been pictured as part of the mitocho...

Non-Invasive Optoacoustic Imaging for In-Depth Cultural Heritage Diagnostics

The complex composition of cultural heritage (CH) items presents significant challenges in assessing their condition and predicting potential risks of material degradation. Typically employed diagnostic optical methods are inevitably limited by light scattering, thus restricting in-depth investigations of objects with complex structural and optical...

Numerical Investigation of Fracture Behaviour of Polyurethane Adhesives under the Influence of Moisture

The mechanical behaviour of polymer adhesives is influenced by the environmental conditions leading to ageing and affecting the integrity of the material. The polymer adhesives have hygroscopic behaviour and tend to absorb moisture from the environment, causing the material to swell without applying external load. The focus of the work is to invest...

Generating normative data from web-based administration of the Cambridge Neuropsychological Test Automated Battery using...

Published in Frontiers in Digital Health

Introduction Normative cognitive data can distinguish impairment from healthy cognitive function and pathological decline from normal ageing. Traditional methods for deriving normative data typically require extremely large samples of healthy participants, stratifying test variation by pre-specified age groups and key demographic features (age, sex...