Su, Kai Wang, Jianguo Lv, Yang Tian, Ming Zhao, You-Yang Minshall, Richard D Hu, Guochang
Published in
American journal of physiology. Lung cellular and molecular physiology
Ventilator-induced lung injury is associated with an increase in mortality in patients with respiratory dysfunction, although mechanical ventilation is an essential intervention implemented in the intensive care unit. Intrinsic molecular mechanisms for minimizing lung inflammatory injury during mechanical ventilation remain poorly defined. We hypot...
Jia, Xianxian Wu, Bo Huang, Jinhui Fan, Lin Yang, Miao Xu, Wei
Published in
International journal of molecular medicine
Arrested alveolar development is the main pathological characteristic of neonatal bronchopulmonary dysplasia (BPD); however, a number of studies aiming to improve alveolarization have focused on alveolar epithelial cell damage and impairment. Previously, the authors reported that the Wnt signaling plays a key role in alveolar injury and repair by r...
Passaro, Fabiana De Martino, Ilaria Zambelli, Federico Di Benedetto, Giorgia Barbato, Matteo D'Erchia, Anna Maria Manzari, Caterina Pesole, Graziano Mutarelli, Margherita Cacchiarelli, Davide
...
Published in
The Journal of biological chemistry
The Yes-associated protein (YAP), one of the major effectors of the Hippo pathway together with its related protein WW-domain-containing transcription regulator 1 (WWTR1; also known as TAZ), mediates a range of cellular processes from proliferation and death to morphogenesis. YAP and WW-domain-containing transcription regulator 1 (WWTR1; also known...
Mohseni, Roohollah Alavian, Seyed Moayed Sadeghabadi, Zahra Arab Heiat, Mohammad
Published in
Molecular biology reports
This study was conducted to present the mechanism of the therapeutic effects of Chlorella vulgaris extract (CV) on the carbon tetrachloride (CCl4) induced liver fibrosis model. Primarily, the mechanism of antioxidant effects of CV were investigated via measuring the expression of forkhead box protein O1 (FOXO1) and phosphorylated 5' adenosine monop...
Ding, Panfeng Liang, Bo Shou, Jixin Wang, Xinjun
Published in
International journal of molecular medicine
The long non‑coding RNA KCNQ1OT1 is generally recognized as an oncogenic molecule in several human malignant tumors. However, to the best of our knowledge, the role of KCNQ1OT1 in glioma has not been fully investigated. The current study aimed to probe the biological function of KCNQ1OT1 in human glioma cell lines and its mechanisms. The glioma cel...
Shimizu, Kosuke Matsumoto, Hiroaki Hirata, Hiroshi Ueno, Koji Samoto, Masahiro Mori, Junichi Fujii, Nakanori Kawai, Yoshihisa Inoue, Ryo Yamamoto, Yoshiaki
...
Published in
Oncology reports
Yes‑associated protein (YAP) is a transcription‑coupling factor that plays a central role in the Hippo pathway, and its activation regulates cell proliferation and carcinogenesis. YAP activation has been reported in various malignancies, conferring tumors with migratory and invasive abilities. Several studies have suggested that YAP expression is c...
Tong, Zongrui Jin, Lulu Oliveira, Joaquim Miguel Reis, Rui L. Zhong, Qi Mao, Zhengwei Gao, Changyou
Published in
Bioactive Materials
• Introduction of adaptable hydrogels with dynamic mechanical properties as 3D extracellular matrix. • Summary of reversible linkages based on supramolecular interactions and dynamic covalent bonds. • Discussion of how adaptable hydrogels provide dynamic mechanical microenvironment and influence cell behaviors and fate. • Overview of applications o...
Niu, Lele Jia, Yuanbo Wu, Mian Liu, Han Feng, Yanjing Hu, Yan Zhang, Xiaohui Gao, Dengfeng Xu, Feng Huang, Guoyou
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Published in
Journal of cellular physiology
Cardiac fibrosis is a common pathway leading to heart failure and involves continued activation of cardiac fibroblasts (CFs) into myofibroblasts during myocardium damage, causing excessive deposition of the extracellular matrix (ECM) and thus increases matrix stiffness. Increasing evidence has shown that stiffened matrix plays an important role in ...
Huang, Luping Li, Shan Dai, Qinxue Zhang, Anqi Yu, Qimin Du, Wenwen Zhao, Peiqi Mo, Yunchang Xu, Kaiwei Chen, Sijia
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Published in
Experimental neurology
Astrocytic Yes-associated protein (YAP) has been implicated in astrocytic proliferation and differentiation in the developing neocortex. However, the role of astrocytic YAP in diseases of the nervous system remains poorly understood. Here, we hypothesized that astrocytic YAP exerted a neuroprotective effect against cerebral ischemic injury in rats ...
Wang, Hao Xu, Ping Luo, Xiaofang Hu, Mingyu Liu, Yamin Yang, Yike Peng, Wei Bai, Yuxiang Chen, Xuehai Tan, Bin
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Published in
Biology of reproduction
Fetal growth restriction (FGR) is a condition in which a newborn fails to achieve his or her prospective hereditary growth potential. This condition is associated with high newborn mortality, second only to that associated with premature birth. FGR is associated with maternal, fetal, and placental abnormalities. Although the placenta is considered ...
