Chen, Bin Liu, Bin Yu, Tao Han, Yun-Feng Wu, Chao Wang, Zhen-Yu
Published in
Chinese Medical Journal
Background: The Nuclear Dbf2-related (NDR1) kinase is a member of the NDR/LATS family, which was a supplementary of Hippo pathway. However, whether NDR1 could inhibit glioblastoma (GBM) growth by phosphorylating Yes-associated protein (YAP) remains unknown. Meanwhile, the role of NDR1 in GBM was not clear. This study aimed to investigate the role o...
Hayashi, Hiromitsu Uemura, Norio Zhao, Liu Matsumura, Kazuki Sato, Hiroki Shiraishi, Yuta Baba, Hideo
Published in
Frontiers in Oncology
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer. Despite major advances in defining the molecular mutations driving PDAC, this disease remains universally lethal with an overall 5-year survival rate of only about 7–8%. Genetic alterations in PDAC are exemplified by four critical genes (KRAS, TP53, CDKN2A, and ...
Jia, Yu Li, Hui-Yan Wang, Ying Wang, Jue Zhu, Jing-Wen Wei, Yan-Yan Lou, Lu Chen, Xing Mo, Shi-Jing
Published in
International Journal of Biological Sciences
Autophagy and glycolysis are two catabolic processes that manipulate pancreatic ductal adenocarcinoma (PDAC) development in response to hypoxia sensing, yet the underlying mechanism of how they are interlinked remain elusive. Methods: The functional roles of Unc-51 like kinase 1 and 2 (ULK1/2) in pyruvate kinase M2 (PKM2) transcription and glycolys...
Ma, Jiamei Huang, Xiaoxi
Published in
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
肝细胞癌(hepatocellular carcinoma，HCC)是全球最常见的恶性肿瘤之一，发病率和病死率均较高，然而其发生和发展机制仍不清楚。Hippo信号通路主要通过由核心分子构成的激酶链转导信号，抑制转录共激活因子入核，减少下游促增殖基因转录。近年来发现Hippo信号通路不仅调控肝发育和肝切除后的再生，而且与HCC的发生也密切相关。Hippo信号通路可调控HCC细胞增殖、转移、自噬、代谢重编程及免疫微环境，参与HCC对多种药物产生耐药的过程。研究Hippo信号通路在HCC中的作用对发现新的治疗靶点有重要意义。.
Yong, Jiaxin Li, Yuan Lin, Sihan Wang, Zhenning Xu, Yan
Published in
Drug Design, Development and Therapy
Gastric cancer (GC) is one of the most common cancers globally, threatening global health. The deregulation of the Hippo signaling pathway has been discovered in GC and may be related to cancer development, proliferation, metastasis, and drug resistance. Yes-associated protein (YAP), as a downstream effector of the Hippo signaling pathway and a cru...
Xiong, Jie Dong, Xuefei Li, Shengnan Jiang, Fan Chen, Jing Yu, Shiran Dong, Bo Su, Qing
Published in
Frontiers in Physiology
Diabetic cardiomyopathy (DCM) is a common complication associated with diabetes. The (pro)renin receptor (PRR) is an important member of the local tissue renin-angiotensin system and plays a vital role in many cardiovascular diseases. Yes-associated protein (YAP) also plays a crucial role in many cardiovascular diseases. However, the mechanism resp...
Li, Xiao Lin, Yi-Ying Tan, Jia-Yi Liu, Kang-Lun Shen, Xiao-Ling Hu, Ying-Jie Yang, Rui-Yi
Published in
Pharmaceutical Biology
Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumour cell growth by inducing cell cycle arrest. However, its underlying anticancer mechanism remains unclear. Objective The effects of LAF on the Hippo-Yes-associated protein (YAP) signalling pathway, which plays an important role in cancer progression, were...
Jiang, Linhua Zhang, Jiawen Xu, Qixuan Wang, Bin Yao, Yizhou Sun, Liang Wang, Xuchao Zhou, Diyuan Gao, Ling Song, Shiduo
...
Published in
Oncology letters
Yes-associated protein (YAP), as a major downstream effector in the Hippo signaling pathway, is considered as an oncogene in cancer. The present study aimed to investigate the potential role of YAP in the development and progression of colorectal cancer (CRC). The mRNA and protein expression levels of YAP in human CRC tissue samples and adjacent no...
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Liver cancer is one of the most common cancers worldwide, and its prevalence and mortality rate are increasing due to the lack of biomarkers and effective treatments. The Hippo signaling pathway has long been known to control liver size, and genetic depletion of Hippo kinases leads to liver cancer in mice through activation of the downstream effect...
Jia, Jinjing Mo, Xiumei Yan, Fenggen Liu, Junfeng Ye, Siqi Zhang, Yu Lin, Ying Li, Hongyi Chen, Dacan
Published in
Journal of dermatological science
Atopic dermatitis (AD) is characterized by impaired skin barrier function and immune system dysfunction. The expression and role of Yes-associated protein (YAP) in AD are unclear. To characterize the role of the YAP in T cell imbalance and epidermal keratinocyte dysfunction in the pathogenesis of AD. We included 35 patients with AD (21 acute and 14...
