Li, Hong Sun, Yuchuan Li, Qing Luo, Qing Song, Guanbin
Published in
ACS biomaterials science & engineering
A hepatocellular carcinoma tissue has mechanical heterogeneity, where the stiffness gradually increases from the core to the invasion front. Furthermore, there is evidence that stem cells from liver cancer (LCSCs) preferentially enrich the invasion front, exhibiting the stiffest modulus in the tumor. LCSCs have the features of stem/progenitor cells...
Yu, Hongchi Hou, Zhe Chen, Nuoya Luo, Rifang Yang, Li Miao, Michael Ma, Xiaoyi Zhou, Lifeng He, Fugui Shen, Yang
...
Published in
Regenerative Biomaterials
Magnesium alloy (Mg alloy) has attracted massive attention in the potential applications of cardiovascular stents because of its good biocompatibility and degradability. However, whether and how the Mg alloy induces inflammation in endothelial cells remains unclear. In the present work, we investigated the activation of Yes-associated protein (YAP)...
Li, Jiawei Sun, Ziying Lv, Zhongyang Jiang, Huiming Liu, Anlong Wang, Maochun Tan, Guihua Guo, Hu Sun, Heng Wu, Rui
...
Published in
Frontiers in Cell and Developmental Biology
Mesenchymal stem cells (MSCs) are well known for their multi-directional differentiation potential and are widely applied in cartilage and bone disease. Synovial mesenchymal stem cells (SMSCs) exhibit a high proliferation rate, low immunogenicity, and greater chondrogenic differentiation potential. Microtubule (MT) plays a key role in various cellu...
Li, Maoquan Ning, Jinqiu Wang, Jiwei Yan, Qiqian Zhao, Ke Jia, Xiaoshi
Published in
International Journal of Molecular Medicine
Chondrocytes are well adapted to hypoxia and produce more functional extracellular matrix in low oxygen environments in vitro . In our previous study, methyltransferase SET domain containing (SETD)7 regulated chondrocyte activity in hypoxic conditions. However, the precise association between SETD7 and chondrocyte differentiation under low oxygen p...
Shen, Chen Chen, Jin Hong Oh, Ha Ram Park, Ji Hyun
Published in
FEBS letters
Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without fructose, significantly upregulated SOX2 in murine liver tissue. Treatment with free fatty acids (F...
Xie, Jing Fan, Yonggang Jia, Rongjun Yang, Fan Ma, Liman Li, Lihua
Published in
The Journal of pathology
Mounting clinical evidence has revealed that the vitamin D receptor (VDR) is associated with cholestatic liver injury, although the functions of VDR in this condition remain largely unexplored. Here, we investigated the effects of VDR activation on bile duct ligation (BDL) mice, and the underlying mechanisms were further investigated. A low-calcemi...
Sun, Congrui He, Bin Sun, Mingsheng Lv, Xiaoshuo Wang, Feng Chen, Jie Zhang, Jianbin Ye, Zhidong Wen, Jianyan Liu, Peng
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Published in
Frontiers in Cardiovascular Medicine
Atherosclerosis and its complications diseases remain leading causes of cardiovascular morbidity and mortality, bringing a massive burden on public health worldwide. Atherosclerosis is recognized as chronic inflammation, and involves several highly correlated processes, including lipid metabolism dysfunction, endothelial cell dysfunction, inflammat...
Fan, Yali Sun, Quanmei Li, Xia Feng, Jiantao Ao, Zhuo Li, Xiang Wang, Jiandong
Published in
Frontiers in Cell and Developmental Biology
Mechanical factors in the tumor microenvironment play an important role in response to a variety of cellular activities in cancer cells. Here, we utilized polyacrylamide hydrogels with varying physical parameters simulating tumor and metastatic target tissues to investigate the effect of substrate stiffness on the growth, phenotype, and chemotherap...
Yan, Jie Shi, Litong Lin, Shan Li, Yi
Published in
Bioengineered
Williamson, Daniel
Yes-associated protein (YAP) is a transcription regulator with a highly significant role in a wide variety of cancers. When YAP is transported into the cell nucleus, it activates a programme of genes which promote cell proliferation and confer resistance to regulatory signals that normally limit tissue growth. YAP has been shown to promote malignan...
