Liu, Haitao Zhang, Sha Liu, Yi Ma, Jing Chen, Wei Yin, Tao Li, Tongbin Liang, Bin Tao, Ling
Published in
Respiratory research
Pulmonary hypertension (PH) is a progressive and fatal cardiopulmonary disease characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance and artery pressure. Vascular remodeling is associated with the excessive cell proliferation and migration of pulmonary artery smooth muscle cells (PASMCs). In this paper, the effe...
Yang, Xi Zou, Rong Dai, Xiaochan Wu, Xinyuan Yuan, Fei Feng, Yifan
Published in
Experimental cell research
Subretinal fibrosis causes local damage to the retina and irreversible vision loss, as the final stage of neovascular age-related macular degeneration (nAMD). More recently, the endothelial-to-mesenchymal transition (EndoMT) has been considered one of the most significant sources of myofibroblasts in subretinal fibrosis, though the underpinning mol...
Wu, Dongke Wang, Wei Li, Xinyue Yin, Bo Ma, Yunqing
Published in
The international journal of biochemistry & cell biology
Systemic sclerosis (SSc) is a heterogeneous disease with skin fibrosis. Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) is associated with fibrotic response. This work attempted to determine the precise mechanism of YAP/TAZ in SSc. Single-cell sequencing (scRNA-seq) was used to analyse the differential gene exp...
Zhang, Wei Li, Jing
Published in
Investigative ophthalmology & visual science
Both epidermal growth factor receptor (EGFR) and the Yes-associated protein (YAP) signaling pathway are implicated in cell proliferation and differentiation. In this study, we explored whether the formation of proliferative vitreoretinopathy (PVR) depends on the interaction of the EGFR receptor and YAP pathway. We studied the effects of EGFR and YA...
Zou, Rong Feng, Yi-Fan Xu, Ya-Hui Shen, Min-Qian Zhang, Xi Yuan, Yuan-Zhi
Published in
International Journal of Ophthalmology
AIM To reveal whether and how Yes-associated protein (YAP) promotes the occurrence of subretinal fibrosis in age-related macular degeneration (AMD). METHODS Cobalt chloride (CoCl2) was used in primary human umbilical vein endothelial cells (HUVECs) to induce hypoxia in vitro . Eight-week-old male C57BL/6J mice weighing 19-25 g were used for a choro...
Moloudizargari, Milad Asghari, Mohammad Hossein Nabavi, Seyed Fazel Gulei, Diana Berindan-Neagoe, Ioana Bishayee, Anupam Nabavi, Seyed Mohammad
Published in
Seminars in cancer biology
The current era of cancer research has been continuously advancing upon identifying novel aspects of tumorigenesis and the principal mechanisms behind the unleashed proliferation, invasion, drug resistance and immortality of cancer cells in hopes of exploiting these findings to achieve a more effective treatment for cancer. In pursuit of this goal,...
Thines, Louise Gorisse, Laëtitia Li, Zhigang Sayedyahossein, Samar Sacks, David B
Published in
The Journal of biological chemistry
The Hippo signaling pathway regulates tissue growth and cell fate, and its dysregulation can induce tumorigenesis. When Hippo is activated by cell-cell contact, extracellular signals, or cell polarity among others, the large tumor suppressor 1 (LATS1) kinase catalyzes inhibitory phosphorylation of the transcriptional coactivator Yes-associated prot...
Zhou, Junmei Sun, Chunbao Yang, Lu Wang, Jinhui Jn-Simon, Natacha Zhou, Chen Bryant, Andrew Cao, Qi Li, Chenglong Petersen, Bryon
...
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yes-associated protein (YAP), a central effector in the Hippo pathway, is involved in the regulation of organ size, stem cell self-renewal, and tissue regeneration. In this study, we observed YAP activation in patients with alcoholic steatosis, hepatitis, and cirrhosis. Accumulation of this protein in the nucleus was also observed in murine livers ...
Chen, Fei Wang, Qifei Mu, Yushu Sun, Shibin Yuan, Xulong Shang, Pan Ji, Bo
Published in
Journal of molecular recognition : JMR
Human Yes-associated protein (YAP) is involved in the Hippo signaling pathway and serves as a coactivator to modulate gene expression, which contains a transactivation domain (TD) responsible for binding to the downstream TEA domain family (TEAD) of transcription factors and two WW1/2 domains that recognize the proline-rich motifs (PRMs) present in...
Zhao, Boyuan Tang, Mei Lv, Yonggang
Published in
Human cell
Breast cancer is life threatening among women because its migration by hematogenous metastasis, where, besides biochemical cues, breast circulating tumor cells (CTCs) expose to suspension state and shear stress. However, the combined effects of these mechanical factors on CTCs migration were unclear. Here, suspension state and shear stress were loa...
