Jeong, Bo Young Cho, Kyung Hwa Jeong, Kang Jin Cho, Su Jin Won, Minho Kim, Seung Hwa Cho, Nam Hoon Hur, Gang Min Yoon, Se-Hee Park, Hwan-Woo
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Published in
Cancer letters
Cancer-associated fibroblasts (CAFs) are key structural components of the tumor microenvironment and are closely associated with tumor invasion and metastasis. Lysophosphatidic acid (LPA) is a biolipid produced extracellularly and involved in tumorigenesis and metastasis. LPA has recently been implicated in the education and transdifferentiation of...
Negro, Samuele Lauria, Fabio Stazi, Marco Tebaldi, Toma D'Este, Giorgia Pirazzini, Marco Megighian, Aram Lessi, Francesca Mazzanti, Chiara M Sales, Gabriele
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Published in
Acta neuropathologica communications
Regeneration of the neuromuscular junction (NMJ) leverages on extensive exchange of factors released from motor axon terminals (MATs), muscle fibers and perisynaptic Schwann cells (PSCs), among which hydrogen peroxide (H2O2) is a major pro-regenerative signal. To identify critical determinants of NMJ remodeling in response to injury, we performed t...
huang;, lu zengshu
Pregnancy morbidity induced by anti-phospholipid antibodies (aPL+/PM+) is mainly thought to arise from placental abnormalities. We attempted to investigate the effect of aPL on the activity of Yes-associated protein (YAP) in the trophoblast and how YAP regulated human trophoblasts function. Thus, HTR-8 cells were treated with IgG purified from aPL+...
Wei, Jiayun Yao, Jia Yang, Chendong Mao, Yongcui Zhu, Dan Xie, Ye Liu, Pinyan Yan, Mengchao Ren, Longfei Lin, Yan
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Published in
Journal of Translational Medicine
Background Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains unclear how the heterogeneous physical microenvironment affects stemness expression in cancer cells. Here, we aimed to evaluate matr...
Han, Daniel J Aslam, Rukhsana Misra, Paraish S Chiu, Felix Ojha, Tanvi Chowdhury, Apu Chan, Carmen K Sung, Hoon-Ki Yuen, Darren A Luk, Cynthia T
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Published in
Molecular metabolism
Adipose tissue is a very dynamic metabolic organ that plays an essential role in regulating whole-body glucose homeostasis. Dysfunctional adipose tissue hypertrophy with obesity is associated with fibrosis and type 2 diabetes. Yes-associated protein 1 (YAP) is a transcription cofactor important in the Hippo signaling pathway. However, the role of Y...
Choe, Mu Seog Bae, Chang Min Kim, So Jin Oh, Seung Tack Kown, Yu Jin Choi, Won-Young Han, Ho Jae Baek, Kyung Min Chang, Woochul Kim, Joong Sun
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Published in
Cellular and molecular life sciences : CMLS
Human embryonic stem cells (hESCs) have unique characteristics, such as self-renewal and pluripotency, which are distinct from those of other cell types. These characteristics of hESCs are tightly regulated by complex signaling mechanisms. In this study, we demonstrate that yes-associated protein (YAP) functions in an hESC-specific manner to mainta...
Modaresifar, Khashayar Ganjian, Mahya Díaz-Payno, Pedro J. Klimopoulou, Maria Koedam, Marijke van der Eerden, Bram C.J. Fratila-Apachitei, Lidy E. Zadpoor, Amir A.
Published in
Materials Today Bio
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Klincumhom, Nuttha Lorthongpanich, Chanchao Thumanu, Kanjana Septham, Praphasri Phomyu, Wutthikiat Issaragrisil, Surapol Pavasant, Prasit
Published in
Heliyon
Cell fate decision; FTIR; Hippo signaling pathway; Human periodontal ligament cells; Intermittent compressive force; Yes-associated protein.
Dan, Weichao Fan, Yizeng Hou, Tao Wei, Yi Liu, Bo Que, Taotao Yu, Bixin Zeng, Jin Li, Lei
Published in
Journal of Cancer
Silibinin (SB), a flavonoid extracted from milk thistle seeds, has been found to exert antitumor effects in numerous tumor types. Our previous study reported that SB had anti-metastatic effects in prostate cancer (PCa). However, the exact underlying molecular mechanisms remain to be determined. The present study aimed to investigate the effects of ...
Matsumoto, Ken-Ichi Kawakami, Kohei Yamada, Kazuo Takeshita, Haruo
Published in
Molecular Medicine Reports
Extracellular matrix tenascin-X (TNX) is the largest member of the tenascin family. Our previous study demonstrated that TNX was involved in hepatic dysfunction, including fibrosis, in mice that were administered a high-fat and high-cholesterol diet with high levels of phosphorus and calcium. The present study investigated whether overexpression of...
