Published in Neoplasia (New York, N.Y.)
Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB kinase family member IKK-ε is essential in regulating antiviral innate immunity mediated by IRFs but...
Published in Neurobiology of Disease
• Epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro; • Epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro; • DYRK1A levels and activity is increased in CDKL5 deficient neurons;
Published in Biochemistry and biophysics reports
Whey-acidic-protein (WAP) four-disulphide core (WFDC) proteins have important roles in the regulation of innate immunity, anti-microbial function, and the inhibition of inflammatory proteases at mucosal surfaces. It was recently demonstrated that the WFDC protein, prostate stromal 20 (ps20), encoded by the WFDC1 gene, is a potent growth inhibitory ...
