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with Voltage-gated proton channel as keyword
Wang, Yifan Li, Shu Jie Pan, Juncheng Che, Yongzhe Yin, Jian Zhao, Qing
Published in
Biochemical and Biophysical Research Communications
The newly discovered human voltage-gated proton channel Hv1 is essential for proton transfer, which contains a voltage sensor domain (VSD) without a pore domain. We report here for the first time that Hv1 is specifically expressed in the highly metastatic human breast tumor tissues, but not in poorly metastatic breast cancer tissues, detected by im...
Wang, Yifan Zhang, Shangrong Li, Shu Jie
Published in
Biochemical and Biophysical Research Communications
In contrast to the voltage-gated K+ channels, the voltage-gated proton channel Hv1 contains a voltage-sensor domain but lacks a pore domain. Here, we showed that Hv1 is expressed in the highly metastatic glioma cell SHG-44, but lowly in the poorly metastatic glioma cell U-251. Inhibition of Hv1 activity by 140μM zinc chloride induces apoptosis in t...
Asuaje, Agustín Smaldini, Paola Martín, Pedro Enrique, Nicolás Orlowski, Alejandro Aiello, Ernesto A. Gonzalez León, Carlos Docena, Guillermo Milesi, Verónica
Published in
Pflügers Archiv - European Journal of Physiology
Cellular energetic deregulation is widely known to produce an overproduction of acidic species in cancer cells. This acid overload must be counterbalanced with a high rate of H+ extrusion to maintain cell viability. In this sense, many H+ transporters have been reported to be crucial for cell survival and proposed as antineoplastic target. By the w...
Li, Xuefei Yu, Zhiyuan Zong, Weifeng Chen, Peng Li, Jia Wang, Minghuan Ding, Fengfei Xie, Minjie Wang, Wei Luo, Xiang
...
Published in
Journal of Neuroinflammation
BackgroundSpinal cord injury (SCI) causes neurological dysfunction with devastating consequences. SCI pathogenesis is accompanied by inflammasome activation and neuronal damage. But the spatial pattern and the time course of neuronal pyroptosis and apoptosis after SCI should be further elucidated. The microglial voltage-gated proton channel (Hv1) i...
Murugan, Madhuvika Zheng, Jiaying Wu, Gongxiong Mogilevsky, Rochelle Zheng, Xin Hu, Peiwen Wu, Junfang Wu, Long-Jun
Published in
Molecular Brain
Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stress and inflammatory cascades that can lead to further neuronal loss and motor deficits. Microglial activation is an essential component of the...
