Strümper, D. Gogarten, W. Durieux, M.E. Hartleb, K. van Aken, H. Marcus, M.A.E.
Published in
Fetal Diagnosis and Therapy
Introduction:Maternal hypotension is a major concern in obstetric anesthesia, and concerns have been raised about standard vasopressor therapy with ephedrine. Therefore, we evaluated the maternal and fetal hemodynamic effects of two potential alternatives to ephedrine. Methods: Hypotension was induced by epidural administration of lidocaine in 6 ch...
Dubniks, Maris Persson, Johan Grände, Per-Olof
Published in
Intensive Care Medicine
ObjectiveTo evaluate the effects of change in blood pressure on plasma volume under increased permeability.DesignProspective randomized laboratory study.SubjectSixty-one adult male Sprague–Dawley rats.InterventionsPermeability was increased via an anaphylactic reaction by injection of 0.5 ml dextran 70. One hour later, volume expansion with 15 ml/k...
Kopel, Tal Losser, Marie-Reine Faivre, Valérie Payen, Didier
Published in
Intensive Care Medicine
ObjectiveArginine vasopressin (AVP) is being used increasingly to treat vasodilatory hypotension, although its effects on hepatosplanchnic perfusion have been debated.DesignProspective study in a university-based experimental research laboratory.Subjects and interventionsWe compared the effect of AVP on systemic, gut, and liver blood flow in anesth...
Vincent, Jean-Louis
Published in
Langenbeck's Archives of Surgery
IntroductionSepsis remains a common problem in critically ill patients.DiscussionConsiderable advances have been made in our understanding of the pathophysiology of sepsis and recent years have seen a surge of potential new therapeutic agents for sepsis. Definitions have been rethought and strategies proposed to better characterise patients with se...
Taccone, Fabio Silvio Lubicz, Boris Piagnerelli, Michael Van Nuffelen, Marc Vincent, Jean-Louis De Backer, Daniel
Published in
Neurocritical Care
IntroductionExcessive use of adrenergic agents may result in stunned myocardium.CasesWe report the cases of two patients with subarachnoid hemorrhage (SAH) complicated by cardiogenic shock secondary to triple-H therapy for cerebral vasospasm. Both patients had normal cardiac function on admission and no signs of acute myocardial infarction at the o...
Smith, Heidi Sinson, Grant Varelas, Panayiotis
Published in
Neurocritical Care
IntroductionPropofol infusion syndrome (PRIS) is a rare, but lethal complication of high-dose propofol infusions. We undertook this study to evaluate the incidence of PRIS in a cohort of patients with severe head trauma and its relation to the use of vasopressors.MethodsWe reviewed all patients with severe head trauma admitted to our Neuro-Intensiv...
Byrnes, Matthew C Beilman, Greg J
Published in
The Surgical clinics of North America
The history of adjunctive treatments for severe sepsis has been fraught with more failures than successes. To date, there have been few interventions that have been demonstrated to be efficacious by multiple large, well-designed, multicenter randomized clinical trials. However, recent research into treatment strategies using drotrecogin alfa (activ...
Geppert, A.
Published in
Intensivmedizin und Notfallmedizin
Vom therapeutischen Blickpunkt her stellen die Revaskularisation/Reperfusion bei der Ischämie-getriggerten Herzinsuffizienz und Antiarrhythmika bei der Arrhythmie-getriggerten Herzinsuffizienz wesentliche Säulen der Therapie bei akut dekompensierter Herzinsuffizienz dar. Die medikamentöse Therapie mit Inotropika und Vasopressoren kann jedoch als Ec...
Joannidis, Michael Druml, Wilfred Forni, Lui G. Groeneveld, A. B. Johan Honore, Patrick Oudemans-van Straaten, Heleen M. Ronco, Claudio Schetz, Marie R. C. Woittiez, Arend Jan
Published in
Intensive Care Medicine
BackgroundAcute renal failure on the intensive care unit is associated with significant mortality and morbidity.ObjectivesTo determine recommendations for the prevention of acute kidney injury (AKI), focusing on the role of potential preventative maneuvers including volume expansion, diuretics, use of inotropes, vasopressors/vasodilators, hormonal ...
Jacob, M. Chappell, D.
Published in
Notfall + Rettungsmedizin
Infusionslösungen sind bedeutende Instrumente in der Hand von Notärzten und Intensivmedizinern. Trotzdem werden sie speziell in der Notfallsituation oft nicht als Medikamente mit Wirkungen und Nebenwirkungen behandelt, also mit genauen therapeutischen Zielvorstellungen gewissenhaft indiziert und exakt dosiert, sondern dem Kreislauf eher pauschal un...
