Helwa, Reham Hoheisel, Jörg D.
Published in
Analytical and Bioanalytical Chemistry
Determination of the sequence of the human genome and knowledge of the genetic code have allowed rapid progress in the identification of mammalian proteins. However, far less is known about the molecular mechanisms that control expression of human genes and about the variations in gene expression that underlie many pathological states, including ca...
Alemu, Endalkachew A. Sjøttem, Eva Outzen, Heidi Larsen, Kenneth B. Holm, Turid Bjørkøy, Geir Johansen, Terje
Published in
Cellular and Molecular Life Sciences
The protein kinase C (PKC) family of serine/threonine kinases consists of ten different isoforms grouped into three subfamilies, denoted classical, novel and atypical PKCs (aPKCs). The aPKCs, PKCι/λ and PKCζ serve important roles during development and in processes subverted in cancer such as cell and tissue polarity, cell proliferation, differenti...
Ilsley, Garth Robert
The idea of morphogen gradients encoding positional information for a developing organism has long been discussed in the field of developmental biology, but only recently have quantitative models been proposed that relate measured transcription factor concentrations to enhancer activity. However, successful models are typically computationally time...
Polansky, Julia K. Schreiber, Lisa Thelemann, Christoph Ludwig, Leif Krüger, Melanie Baumgrass, Ria Cording, Sascha Floess, Stefan Hamann, Alf Huehn, Jochen
...
Published in
Journal of Molecular Medicine
The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), a T cell subset critically involved in the maintenance of self-tolerance and prevention of over-shooting immune responses. However, the transcriptional regulation of Foxp3 expression remains incompletely unde...
Mathison, Angela Liebl, Ann Bharucha, Jinai Mukhopadhyay, Debabrata Lomberk, Gwen Shah, Vijay Urrutia, Raul
Published in
Pancreatology
Background: Pancreatic stellate cells are emerging as key players in pathophysiopathological processes underlying the development of pancreatic disease, including pancreatitis and cancer. The cells are scarce in the pancreas making their isolation time and resource use consuming. Methods: Therefore, with the ultimate goal of facilitating mechanisti...
Califano, Andrea
The identification of genes acting synergistically as master regulators of physiologic and pathologic cellular phenotypes is a key open problem in systems biology, Here we use a molecular interaction based approach to identify the repertoire of transcription factors (TFs) of a master regulatory module responsible for synergistic activation of a tum...
Dietz, Karl-Josef Vogel, Marc Oliver Viehhauser, Andrea
Published in
Protoplasma
To optimize acclimation responses to environmental growth conditions, plants integrate and weigh a diversity of input signals. Signal integration within the signalling networks occurs at different sites including the level of transcription factor activation. Accumulating evidence assigns a major and diversified role in environmental signal integrat...
Petrovic, Isidor Nikcevic, Gordan Zaric, Jelen Ruegg, Curzi Stevanovic, Milena
Published in
Open Life Sciences
Angiogenesis, the process of generating new blood vessels, is essential to embryonic development, organ formation, tissue regeneration and remodeling, reproduction and wound healing. Also, it plays an important role in many pathological conditions, including chronic inflammation and cancer. Angiogenesis is regulated by a complex interplay of growth...
Stock, Kristin Nolden, Lars Edenhofer, Frank Quandel, Tamara Brüstle, Oliver
Published in
Cellular and Molecular Life Sciences
In contrast to conventional gene transfer strategies, the direct introduction of recombinant proteins into cells bypasses the risk of insertional mutagenesis and offers an alternative to genetic intervention. Here, we explore whether protein transduction of the gliogenic transcription factor Nkx2.2 can be used to promote oligodendroglial differenti...
Klimaszewska, Krystyna Pelletier, Gervais Overton, Catherine Stewart, Don Rutledge, Robert G.
Published in
Plant Cell Reports
Adult conifers are still recalcitrant in clonal propagation despite significant advances in forest tree biotechnology. Plant regeneration through somatic embryogenesis from explants older than mature zygotic embryos is either difficult or impossible to achieve. To investigate if ectopic expression of transcription factors involved in the induction ...
