Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite ...
Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite ...
Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite ...
Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite ...
Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite ...
Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite ...
Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite ...
Afatinib is a powerful inhibitor of platelet activation, platelet apoptosis and platelet aggregation.
Published in International journal of biological macromolecules
Recently, mixed duplex/quadruplex oligonucleotides have attracted great interest for use as biomedical aptamers. In the case of anti-thrombin aptamers, the addition of duplex-forming sequences to a G-quadruplex module identical or very similar to the best-known G-quadruplex of the Thrombin Binding Aptamer (HD1) results in new or improved biological...
Published in Biochimica et biophysica acta
In blood coagulation, thrombin converts fibrinogen into fibrin monomers that polymerize into a clot network. Thrombin also activates Factor XIII by cleaving the R37-G38 peptide bond of the Activation Peptide (AP) segment. The resultant transglutaminase introduces covalent crosslinks into the fibrin clot. A strategy to modify clot architecture would...
