Fender, Anke C. Kleeschulte, Sonja Stolte, Svenja Leineweber, Katja Kamler, Markus Bode, Johannes Li, Na Dobrev, Dobromir
Published in
Basic Research in Cardiology
The deleterious effects of diabetes in the heart are increasingly attributed to inflammatory signaling through the NLRP3 (NOD, LRR and PYD domains-containing protein 3) inflammasome. Thrombin antagonists reduce cardiac remodeling and dysfunction in diabetic mice, in part by suppressing fibrin-driven inflammation. The role of cellular thrombin recep...
Shin, Jae Ho Song, Yunsun Sheen, Jae Jon Lee, Dongwhane Chung, Jaewoo Lee, Ga Young Jeong, Hyunhee Han, Seongsik Choi, Joon Ho Hwang, Seon Moon
...
Published in
Neurointervention
Purpose We present ultrasound-guided percutaneous low-dose thrombin (200–250 IU) injection for the treatment of iatrogenic femoral pseudoaneurysms. Second, we compared patient and procedure factors between subcutaneous hematoma and pseudoaneurysm groups. Materials and Methods From April 2012 to May 2018, 8,425 patients underwent neurointervention. ...
Peacock, Riley B
The serine protease thrombin plays an essential regulatory role in blood clotting. Prothrombin is converted to the active α-thrombin in response to tissue damage, allowing the enzyme to cleave procoagulative substrates such as fibrinogen and PAR, enabling the formation of the clot. On the other hand, when thrombin binds its protein cofactor thrombo...
Riccardi, Claudia Meyer, Albert Vasseur, Jean-Jacques Russo Krauss, Irene Paduano, Luigi Morvan, François Montesarchio, Daniela
A small library of cyclic TBA analogues (named cycTBA I-IV), obtained by covalently connecting its 5'- and 3'ends with flexible linkers, has been synthesized with the aim of improving its chemical and enzymatic stability, as well as its anticoagulant properties. Two chemical procedures have been exploited to achieve the desired cyclization, based o...
Sharma, Anudeepa Kumar, Deepak Moore, Robert M Deshmukh, Aditi Mercer, Brian M Mansour, Joseph M Moore, John J
Published in
Placenta
We have previously demonstrated two associations of PPROM, (1) inflammation/infection (modeled by tumor necrosis factor (TNF)) and (2) decidual bleeding (modeled by thrombin), both decrease fetal membrane (FM) rupture strength in-vitro. Furthermore, Granulocyte-Macrophage-Colony-Stimulating-Factor (GM-CSF) induced by both TNF and thrombin is a crit...
Rahadian, Arief Fukuda, Daiju Salim, Hotimah Masdan Yagi, Shusuke Kusunose, Kenya Yamada, Hirotsugu Soeki, Takeshi Shimabukuro, Michio Sata, Masataka
Published in
Vascular pharmacology
Diabetic patients have coagulation abnormalities, in which thrombin plays a key role. Whereas accumulating evidence suggests that it also contributes to the development of vascular dysfunction through the activation of protease-activated receptors (PARs). Here we investigated whether the blockade of thrombin attenuates endothelial dysfunction in di...
Sypabekova, Marzhan Korganbayev, Sanzhar González-Vila, Álvaro Caucheteur, Christophe Shaimerdenova, Madina Ayupova, Takhmina Bekmurzayeva, Aliya Vangelista, Luca Tosi, Daniele
Published in
Biosensors & bioelectronics
An aptasensor based on etched tilted fiber Bragg grating (eTFBG) is developed on a single-mode optical fiber targeting biomolecule detection. TFBGs were chemically etched using hydrofluoric acid (HF) to partially remove the fiber cladding. The sensor response was coarsely interrogated, resulting on a sensitivity increase from 1.25 nm/RIU (refractiv...
Gangloff, Cedric Mingant, Fanny Theron, Michael Galinat, Hubert Grimault, Ollivier Ozier, Yves Pichavant-Rafini, Karine
Published in
World Journal of Emergency Surgery
AbstractBackgroundAn acute traumatic coagulopathy (ATC) is observed in about one third of severely traumatized patients. This early, specific, and endogenous disorder is triggered by the association of trauma and hemorrhage. The early phase of this condition is characterized by the expression of a bleeding phenotype leading to hemorrhagic shock and...
Isildak, Ibrahim Navaeipour, Farzaneh Afsharan, Hadi Kanberoglu, Gulsah Soydan Agir, Ismail Ozer, Tugba Annabi, Nasim Totu, Eugenia Eftimie Khalilzadeh, Balal
The detection of thrombin by using CdS nanocrystals (CdS NCs), gold nanoparticles (AuNPs) and luminol is investigated in this work. Thrombin is detected by three methods. One is called the quenching method. It is based on the quenching effect of AuNPs on the yellow fluorescence of CdS NCs (with excitation/emission wavelengths of 355/550 nm) when pl...
Isildak, Ibrahim Navaeipour, Farzaneh Afsharan, Hadi Kanberoglu, Gulsah Soydan Agir, Ismail Ozer, Tugba Annabi, Nasim Totu, Eugenia Eftimie Khalilzadeh, Balal
Published in
Microchimica Acta
The detection of thrombin by using CdS nanocrystals (CdS NCs), gold nanoparticles (AuNPs) and luminol is investigated in this work. Thrombin is detected by three methods. One is called the quenching method. It is based on the quenching effect of AuNPs on the yellow fluorescence of CdS NCs (with excitation/emission wavelengths of 355/550 nm) when pl...