Tsilia, Varvara Uyttendaele, Mieke Kerckhof, Frederiek-Maarten Rajkovic, Andreja Heyndrickx, Marc Van de Wiele, Tom
Published in
Foodborne pathogens and disease
Adhesion of pathogenic bacteria to intestinal mucus, the protective layer of the gastrointestinal epithelium, is often considered a virulence factor. The ability of food-poisoning Bacillus cereus strains to attach to mucus and the factors affecting this interaction have not yet been investigated. Therefore, the role of adhesion in pathogenesis of B...
Mayer, Sandra C Gilsbach, Ralf Preissl, Sebastian Monroy Ordonez, Elsa Beatriz Schnick, Tilman Beetz, Nadine Lother, Achim Rommel, Carolin Ihle, Hannah Bugger, Heiko
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Published in
Circulation research
In chronic heart failure, increased adrenergic activation contributes to structural remodeling and altered gene expression. Although adrenergic signaling alters histone modifications, it is unknown, whether it also affects other epigenetic processes, including DNA methylation and its recognition. The aim of this study was to identify the mechanism ...
Shang, C Chen, Q Dell, A Haslam, SM De Vos, WH Van Damme, EJ
Scott, Susana van der Sande, Marianne Faye-Joof, Tisbeh Mendy, Maimuna Sanneh, Bakary Barry Jallow, Fatou de Melker, Hester van der Klis, Fiona van Gageldonk, Pieter Mooi, Frits
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Published in
The Pediatric infectious disease journal
These data provide evidence that B. pertussis is being transmitted within this population despite high vaccination coverage. Re-infection may occur implying that immunity from childhood vaccination may not be lifelong. In the absence of data on actual clinical cases of pertussis, seroprevalence studies remain valuable tools to assess the transmissi...
Franki, I. Desloovere, K. De Cat, J. Tijhuis, W. Molenaers, G. Feys, H. Vanderstraeten, G. Van den Broeck, Christine
Background. Cerebral palsy (CP) is characterized by a heterogeneous nature with a variety of problems. Therefore, individualized physical therapy might be more appropriate to address the needs for these children. Aim.The first aim was to compare the effectiveness of an individually-defined therapy program (IT) and a general therapy program (GT) on ...
Hong, SW Choi, EB Min, TK Kim, JH Kim, MH Jeon, SG Lee, BJ Gho, YS Jee, YK Pyun, BY
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Skin barrier disruption and dermal inflammation are key phenotypes of atopic dermatitis (AD). Staphylococcus aureus secretes extracellular vesicles (EVs), which are involved in AD pathogenesis. Here, we evaluated the role of EVs-associated alpha-hemolysin derived from S. aureus in AD pathogenesis. alpha-hemolysin production from S. aureus was detec...
Hachani, Abderrahman Allsopp, Luke P Oduko, Yewande Filloux, Alain
Published in
The Journal of biological chemistry
The bacterial type VI secretion system (T6SS) is a supra-molecular complex akin to bacteriophage tails, with VgrG proteins acting as a puncturing device. The Pseudomonas aeruginosa H1-T6SS has been extensively characterized. It is involved in bacterial killing and in the delivery of three toxins, Tse1-3. Here, we demonstrate the independent contrib...
Sanders, Melanie Guo, Yirong Iyer, Abhishek García, Yara Ruiz Galvita, Anastasia Heyerick, Arne Deforce, Dieter Risseeuw, Martijn D P Van Calenbergh, Serge Bracke, Marc
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Published in
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
An immunogen synthesis strategy was designed to develop anti-deoxynivalenol (DON) monoclonal antibodies with low cross-reactivity against structurally similar trichothecenes. A total of eight different DON immunogens were synthesised, differing in the type and position of the linker on the DON molecule. After immunisation, antisera from mice immuni...
Devreese, Mathias Broekaert, Nathan De Mil, Thomas Fraeyman, Sophie De Backer, Patrick Croubels, Siska
Antonissen, Gunther Van Immerseel, Filip Pasmans, Frank Ducatelle, Richard Haesebrouck, Freddy Timbermont, Leen Verlinden, Marc Janssens, Geert Paul Jules Eeckhaut, Venessa Eeckhout, Mia
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Published in
PloS one
Both mycotoxin contamination of feed and Clostridium perfringens-induced necrotic enteritis have an increasing global economic impact on poultry production. Especially the Fusarium mycotoxin deoxynivalenol (DON) is a common feed contaminant. This study aimed at examining the predisposing effect of DON on the development of necrotic enteritis in bro...
