Ross, Susan Dickinson
Published in
Drug information journal : DIJ / Drug Information Association
ObjectiveTo present a case study of the application of systematic review methods to the pharmacovigilance of drugs post-marketing.BackgroundThe methods of systematic review are evolving as a tool for health care decision makers to assist with the comprehensive assessment of large amounts of information. As the methods have evolved, so have the appl...
Altman, Douglas G.
Published in
Hormone Research in Paediatrics
It is important to recognize the studies that yield the most reliable evidence upon which to base treatment decisions. Randomized trials have a particular place in providing high-quality unbiased comparisons of different treatments, when carried out to a high methodological standard. Empirical evidence shows that such trials are not always done wel...
Vohra, S. Eddy, A. Levin, A. V. Taylor, G. Laxer, R. M.
Published in
Pediatric Nephrology
We identified 35 cases of tubulointerstitial nephritis and uveitis (TINU), 31 from a MEDLINE search (1966–1996) of the English literature and 4 from our hospital records (1988–1996). To meet the case definition, the patient had to be less than 18 years old and have TINU of unknown cause. Common presenting symptoms included fatigue, weight loss, fev...
Connor, Jennie Whitlock, Gary Norton, Robyn Jackson, Rod
Published in
Accident Analysis and Prevention
Hunt, Dereck L. Haynes, R. B.
Published in
The Indian Journal of Pediatrics
A systematic review is a carefully planned and conducted study designed to answer a specific focused clinical question. A systematic review differs from the frequently encountered narrative review article. Systematic review must be completed using a prespecified methodology. The reader must ask eight important questions when reading a systematic re...
Liberati, A. D'Amico, R. Pifferi, S. Telaro, E.
Published in
Intensive Care Medicine
Objective: At least 7 meta-analyses (MA) have been published since 1991 on the effectiveness of antibiotic prophylaxis in Intensive care units (ICU) patients, but controversy still remains about the overall effectiveness and risk-benefits profile of the treatment. This paper aims to summarise available data on effectiveness and discuss reasons why ...
Guidugli, Fabio Castro, Aldemar Araujo [UNIFESP] Atallah, Álvaro Nagib [UNIFESP]
OBJECTIVES: To find the existing clinical evidence on interventions for leptospirosis. The objective is to evaluate the effectiveness and safety of any intervention on leptospirosis through systematic reviews of randomized controlled trials (RCTs).DATA SOURCE: The sources of studies used (where there were no limitations concerning language, date, o...
GUIDUGLI, Fabio CASTRO, Aldemar Araujo ATALLAH, Álvaro Nagib
OBJECTIVES: To find the existing clinical evidence on interventions for leptospirosis. The objective is to evaluate the effectiveness and safety of any intervention on leptospirosis through systematic reviews of randomized controlled trials (RCTs). DATA SOURCE: The sources of studies used (where there were no limitations concerning language, date, ...
Kwok, H. Bissett, I. P. Hill, G. L.
Published in
International Journal of Colorectal Disease
With the widespread introduction of preoperative radiotherapy for rectal cancer and the development of transanal endoscopic microsurgery for selected early lesions, preoperative radiological staging of these tumours has taken on increasing importance. This study is a systematic review to evaluate computed tomography (CT), endorectal sonography (ES)...
McDonagh, Marian Bradley, Matthew Shirley, Alan
Published in
Pharmacy World and Science
Hypertension is very common, occurring in over 50% of older people, and is a major risk factor for stroke and ischaemic heart disease. Based on systematic reviews there is evidence to show that drug treatment of hypertension in older people saves lives and prevents unnecessary morbidity. There is also strong evidence to support the use of diuretics...
