Kiuchi, Márcio Galindo Carnagarin, Revathy Nolde, Janis M Lugo-Gavidia, Leslie Marisol Ward, Natalie C Schlaich, Markus P
Published in
Expert review of cardiovascular therapy
The concept of targeting the renal sympathetic nerves therapeutically to lower blood pressure (BP) is based on their crucial role in regulating both renal and cardiovascular control. These effects are mainly mediated via three major mechanisms including alteration of renal blood flow, renin-release, and Na+ retention. Initial surgical approaches ap...
Rahal, Danny Tashjian, Sarah M Karan, Maira Eisenberger, Naomi Galván, Adriana Fuligni, Andrew J Hastings, Paul D Cole, Steve W
Parasympathetic nervous system activity can downregulate inflammation, but it remains unclear how parasympathetic nervous system activity relates to antiviral activity. The present study examined associations between parasympathetic nervous system activity and cellular antiviral gene regulation in 90 adolescents (Mage = 16.28, SD = 0.73; 51.1% fema...
Perdikari, Aliki Cacciottolo, Tessa Henning, Elana Mendes de Oliveira, Edson Keogh, Julia M Farooqi, I Sadaf
Peer reviewed: True / Funder: Bernard Wolfe Health Neuroscience Endowment / Funder: Botnar Fondation / Funder: NIHR Cambridge Biomedical Research Center / Funder: NIHR Senior Investigator Award / Obesity, defined as an excess of adipose tissue that adversely affects health, is a major cause of morbidity and mortality. However, to date, understandin...
Perdikari, Aliki Cacciottolo, Tessa Henning, Elana Mendes de Oliveira, Edson Keogh, Julia M Farooqi, I Sadaf
Peer reviewed: True / Funder: Bernard Wolfe Health Neuroscience Endowment / Funder: Botnar Fondation / Funder: NIHR Cambridge Biomedical Research Center / Funder: NIHR Senior Investigator Award / Obesity, defined as an excess of adipose tissue that adversely affects health, is a major cause of morbidity and mortality. However, to date, understandin...
Rudd, Kristen L Roubinov, Danielle S Jones-Mason, Karen Alkon, Abbey Bush, Nicole R
The etiology of psychopathology is multifaceted and warrants consideration of factors at multiple levels and across developmental time. Although experiences of adversity in early life have been associated with increased risk of developing psychopathology, pathways toward maladaptation or resilience are complex and depend upon a variety of factors, ...
Rudd, Kristen L. Roubinov, Danielle S. Jones-Mason, Karen Alkon, Abbey Bush, Nicole R.
Published in
Development and psychopathology
The etiology of psychopathology is multifaceted and warrants consideration of factors at multiple levels and across developmental time. Although experiences of adversity in early life have been associated with increased risk of developing psychopathology, pathways toward maladaptation or resilience are complex and depend upon a variety of factors, ...
Zuo, Wanyun Liu, Na Xiao, Yunbin Xie, Yonghui Liu, Qiming
Published in
Brazilian Journal of Cardiovascular Surgery
Introduction Pulmonary artery denervation (PADN) can reduce the sympathetic nervous system (SNS) activity, reduce pulmonary artery pressure (PAP), and improve the quality of life in patients with pulmonary hypertension (PH). We conducted a systematic meta-analysis of the effectiveness of PADN in the treatment of PH patients. Methods This is a compr...
Zhu, Ching Rajendran, Pradeep S Hanna, Peter Efimov, Igor R Salama, Guy Fowlkes, Charless C Shivkumar, Kalyanam
Remodeling of injured sympathetic nerves on the heart after myocardial infarction (MI) contributes to adverse outcomes such as sudden arrhythmic death, yet the underlying structural mechanisms are poorly understood. We sought to examine microstructural changes on the heart after MI and to directly link these changes with electrical dysfunction. We ...
Dokshokova, L Franzoso, M Di Bona, A Moro, N Sanchez Alonso, JL Prando, V Sandre, M Basso, C Faggian, G Abriel, H
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Sympathetic neurons densely innervate the myocardium with non-random topology and establish structured contacts (i.e. neuro-cardiac junctions, NCJ) with cardiomyocytes, allowing synaptic intercellular communication. Establishment of heart innervation is regulated by molecular mediators released by myocardial cells. The mechanisms underlying mainten...
Doménech-García, Víctor Peirotén, Alberto Rubio Imaz, Miren Lecea Palsson, Thorvaldur Skuli Herrero, Pablo Bellosta-López, Pablo
Published in
The Korean journal of pain
Widespread pain partially depends upon sensitization of central pain mechanisms. However, mechanisms controlling pain distribution are not completely known. The present study sought to assess skin temperature variations in the area of experimentally-induced pain and potential sex differences. Pressure-pain thresholds (PPTs) were measured on the rig...