Imani, Alireza Parsa, Hoda Chookalaei, Leila Gholami Rakhshan, Kamran Golnazari, Masoomeh Faghihi, Mahdieh
Published in
Arquivos brasileiros de cardiologia
Stress is defined as a complicated state that related to homeostasis disturbances, over-activity of the sympathetic nervous system and hypothalamus-pituitary-adrenal axis responses. Cardiac preconditioning reduces myocardial damages. This study was designed to assess the cardioprotective effects of acute physical stress against ischemia/reperfusion...
Fu, Liang-Wu Tjen-A-Looi, Stephanie C Barvarz, Sherwin Guo, Zhi-Ling Malik, Shaista
Myocardial ischemia evokes powerful reflex responses through activation of vagal and sympathetic afferents in the heart through the release of ischemic metabolites. We have demonstrated that extracellular ATP stimulates cardiac sympathetic afferents through P2 receptor-mediated mechanism, and that opioid peptides suppress these afferents' activity....
Rached, Marie-Therese Millership, Steven J Pedroni, Silvia MA Choudhury, Agharul I Costa, Ana SH Hardy, Darran G Glegola, Justyna A Irvine, Elaine E Selman, Colin Woodberry, Megan C
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OBJECTIVE: Sympathetic nervous system and immune cell interactions play key roles in the regulation of metabolism. For example, recent convergent studies have shown that macrophages regulate obesity through brown adipose tissue (BAT) activation and beiging of white adipose tissue (WAT) via effects upon local catecholamine availability. However, the...
Zhou, Mingmin Liu, Yu Xiong, Liang Quan, Dajun He, Yan Tang, Yanhong Huang, He Huang, Congxin
Published in
Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND Augmented cardiac sympathetic afferent reflex (CSAR) plays a role in enhanced sympathetic activity. Given that a strategy for abolishing augmented CSAR-induced sympathetic activation may be beneficial for protecting against ventricular arrhythmias (VAs) triggered by acute myocardial infarction (AMI), we investigated whether cardiac sympa...
Guo, Zhi-Ling Malik, Shaista
Our previous studies have shown that electroacupuncture (EA) at the Jianshi-Neiguan acupoints (P5-6, overlying the median nerve) attenuates sympathoexcitatory responses through its influence on neuronal activity in the rostral ventrolateral medulla (rVLM). The nucleus tractus solitarii (NTS) receives input from somatic nerve stimulation. Connection...
Malik, Shaista Guo, Zhi-Ling
Our previous studies have shown that electroacupuncture (EA) at the Jianshi-Neiguan acupoints (P5-6, overlying the median nerve) attenuates sympathoexcitatory responses through its influence on neuronal activity in the rostral ventrolateral medulla (rVLM). The nucleus tractus solitarii (NTS) receives input from somatic nerve stimulation. Connection...
Nasi-Er, Buajieer-guli Lou, Xue Zhang, Yinling Sun, Huaxin Zhou, Xianhui Li, Yaodong Zhou, Qina Zhang, Jianghua Tang, Baopeng Lu, Yanmei
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Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Myocardial infarction (MI) is the main cause of heart failure (HF), and sympathetic nerve activity is associated with prognosis chronic heart failure. Renal sympathetic denervation (RDN) is noted for its powerful effect on the inhibition of sympathetic nerve activity. This study investigated the effect of RDN on heart failure in dogs aft...
Muxfeldt, Elizabeth Silaid Chedier, Bernardo Rodrigues, Cibele Isaac Saad
Abstract Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a mineralocorticoid antagonist. RH is common, with 10-20% of the general hypertensives, and its associ...
Wang, Lianguo Morotti, Stefano Tapa, Srinivas Stuart, Samantha D Francis Jiang, Yanyan Wang, Zhen Myles, Rachel C Brack, Kieran E Ng, G André Bers, Donald M
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Key pointsCardiac electrophysiology and Ca2+ handling change rapidly during the fight-or-flight response to meet physiological demands. Despite dramatic differences in cardiac electrophysiology, the cardiac fight-or-flight response is highly conserved across species. In this study, we performed physiological sympathetic nerve stimulation (SNS) whil...
Grotle, Ann-Katrin Crawford, Charles K Huo, Yu Ybarbo, Kai M Harrison, Michelle L Graham, James Stanhope, Kimber L Havel, Peter J Fadel, Paul J Stone, Audrey J
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Patients with type-2 diabetes mellitus (T2DM) have exaggerated sympathetic activity and blood pressure responses to exercise. However, the underlying mechanisms for these responses, as well as how these responses change throughout disease progression, are not completely understood. For this study, we examined the effect of the progression of T2DM o...
