Inomata, Megumi Xu, Shuying Chandra, Pallavi Meydani, Simin N. Takemura, Genzou Philips, Jennifer A. Leong, John M.
Published in
Proceedings of the National Academy of Sciences of the United States of America
Streptococcus pneumoniae is a leading cause of pneumonia and invasive disease, particularly, in the elderly. S. pneumoniae lung infection of aged mice is associated with high bacterial burdens and detrimental inflammatory responses. Macrophages can clear microorganisms and modulate inflammation through two distinct lysosomal trafficking pathways th...
van der Kamp, Imme Draper, Lorraine A. Smith, Muireann K. Buttimer, Colin Ross, R. Paul Hill, Colin
Published in
Pharmaceuticals
Streptococcus pneumoniae is highly pathogenic and causes several mucosal and invasive infections. Due to the rising number of multidrug-resistant (MDR) strains of S. pneumoniae , new antimicrobials with alternative mechanisms of action are urgently needed. In this study, we identified two new Streptococcal phages from the oral microbiome, 23TH and ...
del Rosal, Teresa Caminoa, María Belén González-Guerrero, Alba Falces-Romero, Iker Romero-Gómez, María Pilar Baquero-Artigao, Fernando Sainz, Talía Méndez-Echevarría, Ana Escosa-García, Luis Aracil, Francisco Javier
...
Published in
Frontiers in Pediatrics
Introduction: After the introduction of pneumococcal conjugate vaccines, community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae has decreased whereas Staphylococcus aureus and Streptococcus pyogenes could be increasing. These bacteria have been associated with high rates of complications. Aims: (1) To describe the characteristics of ...
Idris, Mohamad Imran Tai, Sharon Mei Ling Tan, Chong Tin Tan, Kay Sin
Published in
Case Reports in Neurology
Streptococcus pneumoniae are Gram-positive bacteria that are responsible for many types of illnesses including pneumonia, sinus infections, and community-acquired meningitis. One important complication of bacterial meningitis is intracranial vasculopathy. Possible etiologies include vasculitis, vasospasm, endocarditis, or intra-arterial thrombosis....
D’Mello, Adonis Riegler, Ashleigh N. Martínez, Eriel Beno, Sarah M. Ricketts, Tiffany D. Foxman, Ellen F. Orihuela, Carlos J. Tettelin, Hervé
Published in
Proceedings of the National Academy of Sciences of the United States of America
Streptococcus pneumoniae ( Spn ) colonizes the nasopharynx and can cause pneumonia. From the lungs it spreads to the bloodstream and causes organ damage. We characterized the in vivo Spn and mouse transcriptomes within the nasopharynx, lungs, blood, heart, and kidneys using three Spn strains. We identified Spn genes highly expressed at all anatomic...
de Oliveira, José Diogo Macedo, Carlos Fernando Guarnieri, João Paulo de Oliveira Theizen, Thaís Holtz Machado, Daisy Lancellotti, Marcelo
Published in
Genetics and Molecular Biology
S. pneumoniae , commonly known as pneumococcus, is a naturally competent Gram-positive bacterium and is the major cause of pneumonia in elderly and children in developing countries. This pathogen is associated with respiratory diseases affected by pollution. The objective of this work was determining the effect of ash and environmental dust from th...
Wall, Emma C. Brownridge, Philip Laing, Gavin Terra, Vanessa S. Mlozowa, Veronica Denis, Brigitte Nyirenda, Mulinda Allain, Theresa Ramos-Sevillano, Elisa Carrol, Enitan
...
Published in
Frontiers in Cellular and Infection Microbiology
Background Mortality from bacterial meningitis, predominately caused by Streptococcus pneumoniae , exceeds 50% in sub-Saharan African countries with high HIV prevalence. Underlying causes of high mortality are poorly understood. We examined the host and pathogen proteome in the CSF of adults with proven pneumococcal meningitis (PM), testing if ther...
Jullien, Sophie Sharma, Ragunath Lhamu Mynak, Mimi Henares, Desiree Muñoz-Almagro, Carmen Bassat, Quique
Published in
BMC Infectious Diseases
BackgroundPneumococcal nasopharyngeal colonization (PNC) generally precedes pneumococcal disease. The purpose of this study was to determine the prevalence of PNC and to identify the pneumococcal serotypes circulating among Bhutanese children under five years of age admitted with clinical pneumonia, before the introduction of pneumococcal conjugate...
Yildiz, Soner Pereira Bonifacio Lopes, João P Bergé, Matthieu González-Ruiz, Víctor Baud, Damian Kloehn, Joachim Boal-Carvalho, Inês Schaeren, Olivier P Schotsaert, Michael Hathaway, Lucy J
...
Published in
eLife
Under eubiotic conditions commensal microbes are known to provide a competitive barrier against invading bacterial pathogens in the intestinal tract, on the skin or on the vaginal mucosa. Here, we evaluate the role of lung microbiota in Pneumococcus colonization of the lungs. In eubiosis, the lungs of mice were dominantly colonized by Lactobacillus...
Sender, Vicky Hentrich, Karina Pathak, Anuj Tan Qian Ler, Alicia Embaie, Bethel Tesfai Lundström, Susanna L Gaetani, Massimiliano Bergstrand, Jan Nakamoto, Rei Sham, Lok-To
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Influenza A virus (IAV)-related mortality is often due to secondary bacterial infections, primarily by pneumococci. Here, we study how IAV-modulated changes in the lungs affect bacterial replication in the lower respiratory tract (LRT). Bronchoalveolar lavages (BALs) from coinfected mice showed rapid bacterial proliferation 4 to 6 h after pneumococ...
