Kataoka, Kosuke Fukuyama, Yoshiko Briles, David E Miyake, Tatsuro Fujihashi, Kohtaro
Published in
Microbiology and immunology
To develop safe vaccines for inducing mucosal immunity to major pulmonary bacterial infections, appropriate vaccine antigens (Ags), delivery systems and nontoxic molecular adjuvants must be considered. Such vaccine constructs can induce Ag-specific immune responses that protect against mucosal infections. In particular, it has been shown that simpl...
Lizcano, Anel Akula Suresh Babu, Ramya Shenoy, Anukul T Saville, Alison Maren Kumar, Nikhil D'Mello, Adonis Hinojosa, Cecilia A Gilley, Ryan P Segovia, Jesus Mitchell, Timothy J
...
Published in
Microbes and infection
Pneumococcal serine-rich repeat protein (PsrP) is a glycoprotein that mediates Streptococcus pneumoniae attachment to lung cells and promotes biofilm formation. Herein, we investigated the transcriptional organization of psrP-secY2A2, the 37-kbp pathogenicity island encoding PsrP and its accessory genes. PCR amplification of cDNA and RNA-seq analys...
Courter, Joshua D Nichols, Kristen R Kazazian, Christina Girotto, Jennifer E
Published in
Journal of the Pediatric Infectious Diseases Society
Current dosing recommendations were found to be suboptimal for specific age groups. A pharmacodynamically guided levofloxacin dosing regimen was determined, but it will need to be studied clinically for safety and tolerability.
Anderson, Ronald Feldman, Charles
Published in
The Journal of infection
Acute pulmonary and cardiac injury remain significant causes of morbidity and mortality in those afflicted with severe pneumococcal disease, with the risk for early mortality often persisting several years beyond clinical recovery. Although remaining to be firmly established in the clinical setting, a considerable body of evidence, mostly derived f...
Barbieri, N. Herrera, M. Salva, S. Villena, J. Alvarez, S.
Published in
Beneficial Microbes
Immunobiotic lactic acid bacteria have become an interesting alternative for the prevention of respiratory infections. Previously, we demonstrated that the nasal administration of Lactobacillus rhamnosus CRL1505, during repletion of malnourished mice, resulted in diminished susceptibility to the challenge with the respiratory pathogen Streptococcus...
Nagaraj, Geetha Ganaie, Feroze Govindan, Vandana Ravikumar, Kadahalli Lingegowda
Published in
Pneumonia
BackgroundPrecise serotyping of pneumococci is essential for vaccine development, to better understand the pathogenicity and trends of drug resistance. Currently used conventional and molecular methods of serotyping are expensive and time-consuming, with limited coverage of serotypes. An accurate and rapid serotyping method with complete coverage o...
Hajaj, Barak Yesilkaya, Hasan Shafeeq, Sulman Zhi, Xiangyun Benisty, Rachel Tchalah, Shiran Kuipers, Oscar P. Porat, Nurith
Published in
Frontiers in Cellular and Infection Microbiology
Streptococcus pneumoniae is a facultative anaerobic pathogen. Although it maintains fermentative metabolism, during aerobic growth pneumococci produce high levels of H2O2, which can have adverse effects on cell viability and DNA, and influence pneumococcal interaction with its host. The pneumococcus is unusual in its dealing with toxic reactive oxy...
Farhat, Khalil Bodart, Gwennaëlle RENARD, Jeanne de Chantal Desmet, Christophe MOUTSCHEN, Michel Beguin, Yves Baron, Frédéric Salvatori, Roberto Geenen, Vincent Martens, Henri
...
In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a consensus about GH immunomodulatory properties. These studies investigated the immune and anti-infectious response of dwarf Ghrh-/- mice presenting a se...
Neves, Felipe P G Cardoso, Nayara T Snyder, Robert E Marlow, Mariel A Cardoso, Claudete A A Teixeira, Lúcia M Riley, Lee W
Published in
Vaccine
In 2010, the 10-valent pneumococcal conjugate vaccine (PCV10) was introduced free of charge in Brazil as part of the public immunization program. Here we investigated the carriage prevalence, colonization risk factors, capsular types, and antimicrobial resistance among pneumococcal isolates obtained from children in Brazil four years after routine ...
Karasartova, Djursun Gazi, Umut Tosun, Ozgur Gureser, Ayse S. Sahiner, Ibrahim T. Dolapci, Mete Ozkan, Aysegul T.
Published in
Journal of Clinical Immunology
PurposeSplenectomy is associated with increased risk of overwhelming post-splenectomy infections despite proper anti-pneumococcal vaccination. As most studies concentrated on vaccination-induced humoral immunity, the cellular immune responses triggered in splenectomized patients are not yet well studied. The present study aims to investigate this a...
