Ribes, S. Zacke, L. Nessler, S. Saiepour, N. Avendaño-Guzmán, E. Ballüer, M. Hanisch, U. K. Nau, R.
Published in
Journal of Neuroinflammation
BackgroundBacterial meningitis is a fatal disease with a mortality up to 30% and neurological sequelae in one fourth of survivors. Available vaccines do not fully protect against this lethal disease. Here, we report the protective effect of synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG ODN) against the most fr...
Dagan, Ron Jiang, Qin Juergens, Christine Trammel, James Gruber, William C Scott, Daniel A
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Pneumococcal conjugate vaccines (PCVs) elicit lower immune response against serotypes carried before or at the time of vaccination (hyporesponsiveness) in infants. The limited studies conducted to date did not permit comprehensive insights regarding this phenomenon. This study, the largest ever conducted with both carriage and serologic endpoints, ...
Ercoli, Giuseppe Ramos-Sevillano, Elisa Nakajima, Rie de Assis, Rafael Ramiro Jasinskas, Algis Goldblatt, David Felgner, Philip Weckbecker, Gisbert Brown, Jeremy
Published in
Frontiers in Immunology
The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoni...
Ngwa, Donald N. Singh, Sanjay K. Agrawal, Alok
Published in
Frontiers in Immunology
C-reactive protein (CRP) is a component of innate immunity. The concentration of CRP in serum increases in microbial infections including Streptococcus pneumoniae infection. Employing a mouse model of pneumococcal infection, it has been shown that passively administered human wild-type CRP protects mice against infection, provided that CRP is injec...
Bleakley, Amy S. Licciardi, Paul V. Binks, Michael J.
Published in
Nutrients
Vitamin D is an essential component of immune function and childhood deficiency is associated with an increased risk of acute lower respiratory infections (ALRIs). Globally, the leading childhood respiratory pathogens are Streptococcus pneumoniae , respiratory syncytial virus and the influenza virus. There is a growing body of evidence describing t...
Nikolaou, Elissavet Jochems, Simon P Mitsi, Elena Pojar, Sherin Blizard, Annie Reiné, Jesus Solórzano, Carla Negera, Edessa Carniel, Beatriz Soares-Schanoski, Alessandra
...
Published in
mBio
Colonization of the upper respiratory tract with Streptococcus pneumoniae is the precursor of pneumococcal pneumonia and invasive disease. Following exposure, however, it is unclear which human immune mechanisms determine whether a pathogen will colonize. We used a human challenge model to investigate host-pathogen interactions in the first hours a...
Jiang, Hanfang Meng, Qing Liu, Xiaorong Chen, Hongyu Zhu, Chunqing Chen, Yunsheng
Published in
Infection and Drug Resistance
Introduction To determine the phenotypes and genotypes of invasive Streptococcus pneumoniae ( S. pneumoniae ), 108 strains were isolated from paediatric patients with invasive pneumococcal diseases (IPDs) in Shenzhen from 2014 to 2018. Methods Serotype profiles were defined by multiplex PCR of the capsule gene. Pneumococcal surface protein A (PspA)...
Dupuis, Claire Sabra, Ayman Patrier, Juliette Chaize, Gwendoline Saighi, Amine Féger, Céline Vainchtock, Alexandre Gaillat, Jacques Timsit, Jean-François
Published in
Critical Care
BackgroundCommunity-acquired pneumonia (CAP), especially pneumococcal CAP (P-CAP), is associated with a heavy burden of illness as evidenced by high rates of intensive care unit (ICU) admission, mortality, and costs. Although well-defined acutely, determinants influencing long-term burden are less known. This study assessed determinants of 28-day a...
Nzoyikorera, Néhémie Diawara, Idrissa Fresia, Pablo Maaloum, Fakhreddine Katfy, Khalid Nayme, Kaotar Maaloum, Mossaab Cornick, Jennifer Chaguza, Chrispin Timinouni, Mohammed
...
Published in
BMC Genomics
BackgroundStreptococcus pneumoniae serotype 1 remains a leading cause of invasive pneumococcal diseases, even in countries with PCV-10/PCV-13 vaccine implementation. The main objective of this study, which is part of the Pneumococcal African Genome project (PAGe), was to determine the phylogenetic relationships of serotype 1 isolates recovered from...
Liang, Zhuoxin Fu, Jinjian Li, Ling Yi, Rongsong Xu, Shaolin Chen, Jichang Ye, Xiaohua McGrath, Eric
Published in
Annals of Clinical Microbiology and Antimicrobials
BackgroundStreptococcus pneumoniae (S. pneumoniae) is one of the most common pathogens which can cause morbidity and mortality in pediatric infections worldwide. This study aimed to describe the phenotypic and molecular characteristics of community-acquired pneumonia (CAP)-causing S. pneumoniae recovered from children in Western China.MethodsWe ret...
