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Wang, Yingya Genina, Natalja Müllertz, Anette Rantanen, Jukka
Published in
Journal of pharmaceutical sciences
Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes. However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed...
Yost, Edward Mazel, Vincent Sluga, Kellie K Nagapudi, Karthik Muliadi, Ariel R
Published in
Journal of pharmaceutical sciences
Active pharmaceutical ingredients (API) and excipients are often classified as 'brittle' or 'ductile' based on their yield pressure determined through the Heckel analysis. Such a brittle/ductile classification is often correlated to some measure of elasticity, die-wall stresses, and brittle fracture propensities from studies performed with a handfu...
Lou, Hao Hageman, Michael J
Published in
Journal of pharmaceutical sciences
The papers published by Yalkowsky et al. and Rohrs et al. offer a method to correlate the probability of passing USP content uniformity (CU) test with maximum allowed particle size and distribution. Their work also provides a guidance for setting the particle size specification especially for a low dose drug. However, their methods are developed ba...
Roopwani, Rahul Buckner, Ira S
Published in
Journal of pharmaceutical sciences
Deformation mechanism and strain rate sensitivity of gabapentin powder was investigated in this work. Heckel analysis, specific surface area and indentation hardness measurements revealed an intermediate yield pressure and brittle fracture as the dominant type of deformation mechanism during consolidation. Strain rate sensitivity of gabapentin was ...
Macedo, Joana Samaro, Aseel Vanhoorne, Valérie Vervaet, Chris Pinto, Joao
