Tatsuoka, Misa Osaki, Yosuke Ohsaka, Fumina Tsuruta, Takeshi Kadota, Yoshihiro Tochio, Takumi Hino, Shingo Morita, Tatsuya Sonoyama, Kei
Published in
The British journal of nutrition
SCFA increase serotonin (5-hydroxytryptamine, 5-HT) synthesis and content in the colon in vitro and ex vivo, but little is known in vivo. We tested whether dietary indigestible saccharides, utilised as a substrate to produce SCFA by gut microbiota, would increase colonic 5-HT content in mice. Male C57BL/6J mice were fed a purified diet and water su...
Ambrosio, Maria Rosaria Magli, Elisa Caliendo, Giuseppe Sparaco, Rosa Massarelli, Paola D’Esposito, Vittoria Migliaccio, Teresa Mosca, Giusy Fiorino, Ferdinando Formisano, Pietro
...
Published in
BMC Cancer
Background Serotonin (or 5-Hydroxytryptamine, 5-HT) signals in mammary gland becomes dysregulated in cancer, also contributing to proliferation, metastasis, and angiogenesis. Thus, the discovery of novel compounds targeting serotonin signaling may contribute to tailor new therapeutic strategies usable in combination with endocrine therapies. We hav...
Lalonde, Robert Strazielle, Catherine
Published in
Gene
The function of the Agtpbp1 gene has mainly been delineated by studying Agtpbp1pcd (pcd) mutant mice, characterized by losses in cerebellar Purkinje and granule cells along with degeneration of retinal photoreceptors, mitral cells of the olfactory bulb, thalamic neurons, and alpha-motoneurons. As a result of cerebellar degeneration, cerebellar GABA...
Brenneis, Georg
Published in
BMC Biology
BackgroundPhylogenomic studies over the past two decades have consolidated the major branches of the arthropod tree of life. However, especially within the Chelicerata (spiders, scorpions, and kin), interrelationships of the constituent taxa remain controversial. While sea spiders (Pycnogonida) are firmly established as sister group of all other ex...
Fabà, Lluís de Groot, Nienke Ramis, Guillermo Cabrera-Gómez, Carolina G. Doelman, John
Published in
Porcine Health Management
BackgroundImmune cell activation and perpetuation of inflammation have been attributed to the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). Our hypothesis was that the 5-HT system plays a role in GI health and immunity in post-weaning piglets. A disruption of the 5-HT system post-weaning with transcriptional upregulation of 5-HT receptors...
Redpath, Gregory Deo, Nikita
Published in
Biology Open
Summary: Serotonin is a neurotransmitter associated usually with our mood, yet recent evidence indicates that serotonin regulates the cell uptake process, endocytosis, diversifying the potential roles of serotonin throughout the body.
Santos, Ana Paula Couto, Carlos Ferreira Pereira, Sofia Silva Monteiro, Mariana Pereira
Published in
Neuroendocrinology
COVID-19 is an intriguing infectious condition with multisystemic manifestations and variable outcomes that are influenced by the concomitant presence of non-communicable diseases, such as obesity, diabetes, and cardiovascular disease, which were previously well established epidemics and therefore are considered global syndemics. Although an enormo...
Gallegos, Anthony Isseroff, Roslyn Rivkah
Published in
MethodsX
Image, graphical abstract
Rahi, Md Lifat Sabbir, Wasim Salin, Krishna R. Aziz, Dania Hurwood, David A.
The black tiger shrimp (Penaeus monodon) represents a major crustacean aquaculture species globally. Outbreaks of diseases caused by two particular pathogens, Vibrio parahemolyticus (VP) and white spot syndrome virus (WSSV) severely hamper the production performance of this species. The present study investigated the effects of different doses of t...
Abdelghany, Asmaa K. El-Kashlan, Akram M. Emeash, Hosny H. Khalil, Fatma
Published in
Beni-Suef University Journal of Basic and Applied Sciences
BackgroundAnimal models are used to provide an adequate investigation of brain-behaviour, physiological and path physiological relationships to give insight into human behaviour and the underlying processes of drugs affecting the nervous system. Scopolamine; SCO (alkaloid l-(2)-scopolamine [l-(2)-hyoscine]) has a competitive inhibitory effect on mu...
