Andrzejewski, Marcin Konefał, Marek Podgórski, Tomasz Pluta, Beata Chmura, Paweł Chmura, Jan Marynowicz, Jakub Melka, Kamil Brazaitis, Marius Kryściak, Jakub
...
Published in
PeerJ
Background Physical fitness optimization and injury risk-reducing require extensive monitoring of training loads and athletes’ fatigue status. This study aimed to investigate the effect of a 6-month training program on the training-related stress indicators (creatine kinase – CK; cortisol – COR; serotonin – SER; brain-derived neurotrophic factor – ...
Sagonas, Ioannis Daoussis, Dimitrios
Published in
Joint bone spine
Systemic sclerosis (SSc) is a complex, autoimmune disease characterized by multiple organ fibrosis and vasculopathy. Experimental and clinical evidence indicates that serotonin is crucially involved in the fibrotic process and mediates vascular manifestations such as Raynaud's phenomenon (RP) or pulmonary arterial hypertension (PAH), all key featur...
Krege, John H. Lipton, Richard B. Baygani, Simin K. Komori, Mika Ryan, Sinéad M. Vincent, Maurice
Published in
Pain and Therapy
Introduction As 5-HT1B receptor agonists, triptans produce vasoconstriction and have cardiovascular contraindications and precautions. Lasmiditan, a selective 5-HT1F receptor agonist, has a low affinity for 5-HT1B receptors, does not cause vasoconstriction, and is free of cardiovascular contraindications and precautions. The objective of this post ...
Zhang, Jie Guo, Zhangchao Xie, Qiangli Zhong, Chuanhong Gao, Xiangyu Yang, Qiumei
Published in
BMC Cancer
Background Glioma is one of the main causes of cancer-related mortality worldwide and is associated with high heterogeneity. However, the key players determining the fate of glioma remain obscure. In the present study, we shed light on tumor metabolism and aimed to investigate the role of tryptophan hydroxylase 1 (TPH-1) in the advancement of gliom...
Morstein, Johannes Romano, Giovanna Hetzler, Belinda E Plante, Ambrose Haake, Caleb Levitz, Joshua Trauner, Dirk
Published in
Angewandte Chemie (International ed. in English)
Serotonin receptors play central roles in neuromodulation and are critical drug targets for psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to greatly enhance our understanding of the spatiotemporal dynamics of receptor function. While other neuromodulatory receptors have been successfully rendered photoswitc...
Chen, Zhijie Lin, Yingbo Zhou, Qichun Xiao, Shilin Li, Chan Lin, Rukun Li, Jing Chen, Yifei Luo, Chaohua Mo, Zhixian
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Morphine dependence, a devastating neuropsychiatric condition, may be closely associated with gut microbiota dysbiosis. Ginsenoside Rg1 (Rg1), an active ingredient extracted from the roots of Panax ginseng C.A. Meyer, has potential health-promoting effects on the nervous system. However, its role in substance use disorders remains unclear. Here, we...
Cattarinussi, Giulia Delvecchio, Giuseppe Moltrasio, Chiara Ferro, Adele Sambataro, Fabio Brambilla, Paolo
Published in
Journal of affective disorders
Borderline personality disorder (BPD) is a serious mental condition characterized by instability in identity, interpersonal relationships, emotion regulation and impulsivity. These symptoms seem to be associated to specific brain alterations, which have been largely investigated. In particular, positron emission tomography (PET) and functional near...
Carranza-Aguilar, César J Hernández-Mendoza, Araceli Mejias-Aponte, Carlos Rice, Kenner C Morales, Marisela González-Espinosa, Claudia Cruz, Silvia L
Published in
Cellular and molecular neurobiology
Morphine promotes neuroinflammation after NOD-like receptor protein 3 (NLRP3) oligomerization in glial cells, but the capacity of other opioids to induce neuroinflammation and its relationship to the development of analgesic tolerance is unknown. We studied the effects of morphine and fentanyl on NLRP3 inflammasome activation in glial and neuronal ...
Mujagic, Z Kasapi, M Jonkers, DMAE Garcia Perez, I Vork, L Weerts, ZZRM Serrano Contreras, JI Zhernakova, A Kurilshikov, A Scotcher, J
...
To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS) several modalities of biological and clinical data must be combined. We aimed to identify profiles of faecal microbiota and metabolites associated with IBS and to delineate specific phenotypes of IBS that represent potential pathophysiological mechanisms. F...
Ruyak, Sharon L Noor, Shahani DiDomenico, Jared Sun, Melody S Fernandez Oropeza, Annette K Rodriguez, Dominique E Marquez, Lidia Enriquez Milligan, Erin D Bakhireva, Ludmila N
Published in
Experimental neurology
Opioids and alcohol impact critical serotonin (5-HT) function in the developing placenta and fetus through the actions of immune proinflammatory factors. Yet, possible convergent effects of opioids and alcohol on human placental toll-like receptor 4 (TLR4) activation and subsequent 5-HT homeostasis remain entirely unknown. The purpose of this study...
