Korkmaz, Brice Lesner, Adam Wysocka, Magdalena Gieldon, Artur Håkansson, Maria Gauthier, Francis Logan, Derek T Jenne, Dieter E Lauritzen, Conni Pedersen, John
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Published in
Biochemical pharmacology
Cathepsin C (CatC) is a dipeptidyl-exopeptidase which activates neutrophil serine protease precursors (elastase, proteinase 3, cathepsin G and NSP4) by removing their N-terminal propeptide in bone marrow cells at the promyelocytic stage of neutrophil differentiation. The resulting active proteases are implicated in chronic inflammatory and autoimmu...
Ashraf, Naeem Mahmood Krishnagopal, Akshaya Hussain, Aadil Kastner, David Sayed, Ahmed Mahmoud Mohammed Mok, Yu-Keung Swaminathan, Kunchithapadam Zeeshan, Nadia
Published in
International journal of biological macromolecules
The study involves the isolation and characterization of a serine peptidase, named SP, from Pseudomonas aeruginosa. In addition to basic characterization, the protein was engineered, by site-directed mutagenesis of selected non-catalytic residues, to increase its thermal stability and catalytic activity. Among the eight-point mutations, predicted b...
Conway, Gregory D. Buzza, Marguerite S. Martin, Erik W. Duru, Nadire Johnson, Tierra A. Peroutka, Raymond J. Pawar, Nisha R. Antalis, Toni M.
Published in
Journal of Molecular Medicine
AbstractOvarian cancer is the leading cause of death among all the gynecological cancers in the USA. Ovarian cancer employs a unique mode of metastasis, as exfoliated tumor cells disseminate within the peritoneal cavity, colonizing in several sites as well as accumulating ascites. Tumor recurrence and widespread metastasis are significant factors c...
Nitsche, Christoph
Published in
Biophysical Reviews
Proteases from flaviviruses have gained substantial interest as potential drug targets to combat infectious diseases caused by dengue, West Nile, Zika and related viruses. Despite nearly two decades of drug discovery campaigns, promising lead compounds for clinical trials have not yet been identified. The main challenges for successful lead compoun...
Yun, Tao Hua, Jionggang Ye, Weicheng Yu, Bin Ni, Zheng Chen, Liu Zhang, Cun
Published in
Journal of proteomics
Duck reovirus (DRV), a member of the genus Orthoreovirus in the family Reoviridae, was first isolated from Muscovy ducks. The disease associated with DRV causes great economic losses to the duck industry. However, the responses of duck (Cairna moschata) to the classical/novel DRV (C/NDRV) infections are largely unknown. To reveal the relationship o...
Lambertz, Pascal Theisen, Laura Längst, Natalie Garvie, Colin W MacDonald, Bryan T Yu, John Elowe, Nadine H Zubov, Dmitry Kaushik, Virendar K Wunder, Frank
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Published in
Biochemical pharmacology
Corin (atrial natriuretic peptide-converting enzyme, EC 3.4.21) is a transmembrane serine protease expressed in cardiomyocytes. Corin exerts its cardioprotective effects via the proteolytic cleavage and activation of pro-atrial natriuretic peptide (pro-ANP) to ANP. We recently described an ANP reporter cell line stably expressing the ANP receptor, ...
Chen, Xingchen Leahy, Darren Van Haeften, Jessica Hartfield, Perry Prentis, Peter Van Der Burg, Chloe Surm, Joachim Pavasovic, Ana Madio, Bruno Hamilton, Brett
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Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This led to concerted efforts to discover versatile and robust molecular scaffolds for inhibitor design. ...
Chen, Xingchen Leahy, Darren Van Haeften, Jessica Hartfield, Perry Prentis, Peter Van Der Burg, Chloe Surm, Joachim Pavasovic, Ana Madio, Bruno Hamilton, Brett
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Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This led to concerted efforts to discover versatile and robust molecular scaffolds for inhibitor design. ...
Megale, Ângela Alice Amadeu Magnoli, Fábio Carlos Kuniyoshi, Alexandre Kazuo Iwai, Leo Kei Tambourgi, Denise V. Portaro, Fernanda C. V. da Silva, Wilmar Dias
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases
BackgroundBitis arietans is a venomous snake found in sub-Saharan Africa and in parts of Morocco and Saudi Arabia. The envenomation is characterized by local and systemic reactions including pain, blistering, edema and tissue damage, besides hemostatic and cardiovascular disturbances, which can cause death or permanent disabilities in its victims. ...
Korkut, Gül Gizem Noonin, Chadanat Söderhäll, Kenneth
Published in
Developmental and comparative immunology
The effects of temperature on the progression of White Spot Disease (WSD) have been studied in the freshwater crayfish Pacifastacus leniusculus. In this study, we aimed to understand the reason for previously observed low mortalities with white spot syndrome virus (WSSV) infected crayfish at low temperatures. The susceptibility of freshwater crayfi...
