Lei, Hong Alu, Aqu Yang, Jingyun Ren, Wenyan He, Cai Lan, Tianxia He, Xuemei Yang, Li Li, Jiong Wang, Zhenling
...
Published in
Signal transduction and targeted therapy
The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain or increase the immune responses owing to waning immunity and the emergency of new variant strains. The deficiency of intramuscularly delive...
Sun, Yanan Yu, Xiao Gao, Xingyu Zhang, Chang Sun, Hui Xu, Kaiyi Wei, Dongxu Wang, Qianwen Zhang, Haiying Shi, Yingai
...
Published in
Cell & Bioscience
Background Stem cell senescence is considered as a significant driver of organismal aging. As individuals age, the number of stem cells is declined, and the ability to proliferate and survive is also weakened. It has been reported that metabolism plays an important role in stem cell self-renewal, multilineage differentiation, senescence and fate de...
Li, Su-Ran Bu, Lin-Lin Cai, Lulu
Published in
Signal Transduction and Targeted Therapy
Schoppa, Astrid M. Chen, Xiangxu Ramge, Jan-Moritz Vikman, Anna Fischer, Verena Haffner-Luntzer, Melanie Riegger, Jana Tuckermann, Jan Scharffetter-Kochanek, Karin Ignatius, Anita
...
Published in
Disease Models & Mechanisms
Summary: Osteoblast-lineage specific Sod2 deficiency in mice leads to increased mtROS, impaired osteoblast function, increased adipogenesis, increased osteoclast activity and increased osteoblast senescence, resulting in bone loss.
Jiang, Zhou Wang, Juan Imai, Denise Snider, Tim Klug, Jenna Mangalindan, Ruby Morton, John Zhu, Lida Salmon, Adam B Wezeman, Jackson
...
Published in
Scientific reports
Pharmaceutical intervention of aging requires targeting multiple pathways, thus there is rationale to test combinations of drugs targeting different but overlapping processes. In order to determine if combining drugs shown to extend lifespan and healthy aging in mice would have greater impact than any individual drug, a cocktail diet containing 14 ...
Wang, Hui Xu, Hongyang Lyu, Wenting Xu, Qinghua Fan, Shiwen Chen, Haoran Wang, Dongjin Chen, Jingyu Dai, Jinghong
Published in
Cell death & disease
Idiopathic pulmonary fibrosis (IPF) was considered as a telomere-mediated disease. TERT and TERC correlated with telomere length. Although telomerase gene mutations were associated with IPF, majority patients did not carry mutations. The mechanism by which telomerase expression was regulated in IPF are still unclear. In this study, we aimed to deli...
Chen, H Qin, J Shi, H Li, Q Zhou, S Chen, L
Published in
Osteoarthritis and cartilage
Osteoarthritis (OA) is an age-related degenerative disease accompanied by an increasing number of senescent cells and chronic low-grade inflammation. Rhoifolin (ROF) showed considerable inhibition to inflammation, but its role in chondrocyte senescence and OA progress has not been fully characterized. We aimed to evaluate the protective effects of ...
Yin, Kelvin Patten, Daniel Gough, Sarah de Barros Gonçalves, Susana Chan, Adelyne Olan, Ioana Cassidy, Liam Poblocka, Marta Zhu, Haoran Lun, Aaron
...
Funder: National Institute for Health and Care Research / Funder: Diabetes UK / Funder: BIRAX / Senescence is a stress-responsive tumor suppressor mechanism associated with expression of the senescence-associated secretory phenotype (SASP). Through the SASP, senescent cells trigger their own immune-mediated elimination, which if evaded leads to tum...
Ma, Shanshan Zhou, Xinkui Wang, Yaping Li, Zhe Wang, Yingying Shi, Jijing Guan, Fangxia
Published in
Redox Biology
• MG53 rejuvenates senescent hUC-MSCs in vitro and enhances their therapeutic effects in AD mice. • MG53 facilitates the therapeutic efficacy of young hUC-MSCs in AD mice. • MG53 synergistically enhances the efficacy of hUC-MSCs by activating Nrf2 signaling pathway in AD mice.
Maity, Pallab Iben, Sebastian
Published in
Signal Transduction and Targeted Therapy
