Le microbiote intestinal joue un rôle central pour son hôte. Il participe à la protection de l’hôte via sa fonction barrière, le métabolisme des nutriments, la production de neurotransmetteurs ainsi que le développement et la maturation du système immunitaire. Les pathologies oculaires sont multifactorielles et présentent des composantes environnem...
Sjögren’s syndrome is an immune system disorder with two common symptoms, dry eyes and a dry mouth. The discomfort of dry eye symptoms affects daily lives, results in 30% activity impairment and affects 95% of Sjögren patients [1]. Dry eye disease (DED) is also an independent multifactorial disorder with a prevalence of up to 50% [2]. The ocular su...
Published in Journal francais d'ophtalmologie
In parallel to ocular surface disease in dry eye there is often a dysfunctionality of the lacrimal gland apparatus. The functionality of the lacrimal gland is of major importance for maintenance of ocular surface integrity and health, even in conditions of enhanced stimulation and secretion requirements. Such enhanced secretion demands can push the...
Dry eye disease (DED) is a multifactorial disease of the ocular surface, often leading to chronic ocular pain, with limited efficient treatment options. In numerous cases, it can be associated with neuropathic corneal pain (NCP), even more difficult to manage. Treating NCP is highly challenging, and there is still a current lack of available topica...
Published in Journal francais d'ophtalmologie
To investigate the effect of systemic anti-androgen drugs on tear function tests and the ocular surface. Sixty-four male subjects were included in this study. Subjects who were on anti-androgen treatment for prostate cancer (Group A, n: 31) and those who had received only surgical treatment for prostate cancer (Group B, n: 17) were recruited from t...
Published in Journal francais d'ophtalmologie
Dry eye syndrome caused by Meibomian gland dysfunction (MGD) is a common disease in the general population and impairs quality of life. Intense Pulsed Light (IPL) has mainly been used in dermatology for the treatment of skin disorders, and more recently for MGD-related dry eye. The objective of our study is to evaluate the efficacy and tolerability...
Published in Journal francais d'ophtalmologie
Tumor necrosis factor-inducible gene 6 protein (TSG-6) is member of the hyaluronan-binding protein family (hyaladherins) to which CD44 also belongs. Inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin-1 (IL-1) stimulate TSG-6 production. Recently, however, externally applied TSG-6 has been shown to be effective in the tre...
Published in Journal francais d'ophtalmologie
The goal of this study is to determine a link between benign essential blepharospasm and Sjogren's syndrome by analyzing the presence of extractable nuclear antigens in this population. Seventy-two patients with benign essential blepharospasm (BEB) were included in this study. We eliminated patients with hemifacial spasm or blepharospasm secondary ...
La sécheresse oculaire est une pathologie englobant de vastes notions pouvant dépasser le cadre de l’ophtalmologie. Elle est définie comme une maladie multifactorielle de la surface oculaire caractérisée par une perte de l’homéostasie du film lacrymal et accompagnée de symptômes oculaires, dans laquelle l’instabilité et l’hyperosmolarité du film la...
Les épithéliums de la surface oculaire sont en première ligne pour protéger l'œil des agressions extérieures, notamment des environnements aujourd’hui de plus en plus pollués et toxiques responsables de l’augmentation de l’incidence de la sécheresse oculaire. La cornée et la conjonctive, innervées par les neurones du ganglion trigéminé vont répondr...
