Repky, Stefan Büchele, Gisela Günther, Klaus-Peter Huch, Klaus Brenner, Hermann Stürmer, Til Beyersmann, Jan Brenner, Rolf E. Rothenbacher, Dietrich
Published in
Scientific Reports
To describe the 5 years’ trajectories in functionality and pain of patients with hip or knee osteoarthritis and arthroplasty and analyze the association of these with long-term patients survival. Patients with OA receiving total hip or knee arthroplasty were recruited and completed two sets of standardized questionnaires for functionality and pain ...
Usuba, Fany Solange de Medeiros-Ribeiro, Ana Cristina Novaes, Priscila Aikawa, Nadia Emi Bonfiglioli, Karina Santo, Ruth Miyuki Bonfá, Eloisa Alves, Milton Ruiz
Published in
Scientific Reports
Dry eye disease (DED) is common in Rheumatoid Arthritis (RA) patients. The application of conjunctival goblet cell count as a clinical biomarker to diagnose and respond to treatment can take place in rheumatoid arthritis patients under TNF-inhibitors (TNFi) therapy. This study aimed to investigate the ocular surface parameters and the long-term eff...
Herrick, AL Griffiths-Jones, DJ Ryder, WD Mason, JC Denton, CP
Background: Many of the painful, disabling features of early diffuse cutaneous systemic sclerosis have an inflammatory component and are potentially treatable with corticosteroid therapy. These features include painful and itchy skin, fatigue and musculoskeletal involvement. Yet many clinicians are understandably reluctant to prescribe corticostero...
Pelletier, Jean-Pierre Raynauld, Jean-Pierre Abram, François Dorais, Marc Paiement, Patrice Martel-Pelletier, Johanne
Published in
Scientific Reports
Although intra-articular corticosteroid injections (IACI) are commonly used for the treatment of knee osteoarthritis (OA), there is controversy regarding possible deleterious effects on joint structure. In this line, this study investigates the effects of IACI on the evolution of knee OA structural changes and pain. Participants for this nested cas...
Montero, Fernando Martínez-Barrio, Julia Serrano-Benavente, Belén González, Teresa Rivera, Javier Molina Collada, Juan Castrejón, Isabel Álvaro-Gracia, Jose
Published in
Rheumatology International
Objective To describe clinical characteristics of patients with rheumatic and musculoskeletal diseases (RMDs) and immunosuppressive therapies with Coronavirus disease 2019 (COVID-19) at an academic rheumatology center in Madrid and to identify baseline variables associated with a severe infection requiring hospitalization. Methods We identified SAR...
Wang, Xinling Yu, Yang Huang, Yong Zhu, Mingshuang Chen, Rigao Liao, Zhanghui Yang, Shipeng
Published in
Scientific Reports
The current study was aimed to identify diagnostic gene signature for osteoarthritis (OA). The differentially expressed genes (DEGs) in synovial membrane samples and blood samples were respectively identified from the GEO dataset. The intersection DEGs between synovial membrane and blood were further screened out, followed by the functional annotat...
Hasegawa, Tetsuo Kikuta, Junichi Sudo, Takao Yamashita, Erika Seno, Shigeto Takeuchi, Tsutomu Ishii, Masaru
Published in
Scientific Reports
There have been many attempts to visualize the inflamed joints using multiphoton microscopy. However, due to the hypervascular and multilayered structure of the inflamed synovium, intravital imaging of the deep synovial tissue has been difficult. Here, we established original intravital imaging systems to visualize synovial tissue and pathological ...
Liegl, Gregor Rose, Matthias Knebel, Fabian Stengel, Andreas Buttgereit, Frank Obbarius, Alexander Fischer, H Felix Nolte, Sandra
Published in
Journal of clinical epidemiology
The Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) item bank has been developed to standardize patient-reported PF across medical fields. However, evidence of scoring equivalence across cardiology and rheumatology patients is still missing. Therefore, this study aims to investigate both (1) the extent of di...
Kim, Ki-Jo Moon, Su-Jin Park, Kyung-Su
Published in
Scientific Reports
The network-based proximity between drug targets and disease genes can provide novel insights regarding the repercussions, interplay, and repositioning of drugs in the context of disease. Current understanding and treatment for reversing of the fibrotic process is limited in systemic sclerosis (SSc). We have developed a network-based analysis for d...
Catalina, Michelle D. Bachali, Prathyusha Yeo, Anthony E. Geraci, Nicholas S. Petri, Michelle A. Grammer, Amrie C. Lipsky, Peter E.
Published in
JCI Insight
Transcriptional profiling of lupus patients and healthy controls reveals ancestry-related differences and transcriptional heterogeneity among lupus patients.
