Kirbis, Alexander Waller, Manuel Ricca, Mariana Bont, Zoe Neubauer, Anna Goffinet, Bernard Szövényi, Péter
Published in
Frontiers in Plant Science
Understanding the molecular basis of morphological shifts is a fundamental question of evolutionary biology. New morphologies may arise through the birth/death of genes (gene gain/loss) or by reutilizing existing gene sets. Yet, the relative contribution of these two processes to radical morphological shifts is still poorly understood. Here, we use...
Prokop, Jeremy W Shankar, Rama Gupta, Ruchir Leimanis, Mara L Nedveck, Derek Uhl, Katie Chen, Bin Hartog, Nicholas L Van Veen, Jason Sisco, Joshua S
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Physiological genomics
Precision medicine requires the translation of basic biological understanding to medical insights, mainly applied to characterization of each unique patient. In many clinical settings, this requires tools that can be broadly used to identify pathology and risks. Patients often present to the intensive care unit with broad phenotypes, including mult...
Dolinski, Amanda C Homola, Jared J Jankowski, Mark D Owen, Jennifer C
Published in
Data in brief
The blue-winged teal (Spatula discors) is a recreationally and ecologically important dabbling duck species in North America. Transcriptomic data of this species can be used in public and animal health studies given its role as a natural reservoir host for avian influenza, which can be a zoonotic disease of high concern. Ileum and bursa of Fabriciu...
Guérit, David Marie, Pauline Morel, Anne Maurin, Justine Vérollet, Christel Raynaud-Messina, Brigitte Urbach, Serge Blangy, Anne
Among hematopoietic cells, osteoclasts (OCs) and immature dendritic cells (DCs) are closely related myeloid cells with distinct functions: OCs participate skeleton maintenance while DCs sample the environment for foreign antigens. Such specificities rely on profound modifications of gene and protein expression during OC and DC differentiation. We p...
Bzhalava, Zurab Arroyo Mühr, Laila Sara Dillner, Joakim
Published in
Vaccine
Some head and neck cancers are caused by human papillomavirus (HPV). As HPV vaccination can prevent infection, an estimation of which HPV types have an active viral oncogene transcription in what proportion of tumors might allow estimation of the proportion of head & neck cancers preventable by HPV vaccination. We used all RNA sequencing data from ...
Coutte, Loïc Antoine, Rudy Slupek, Stephanie Solans, Luis Derop, Julien Bonnefond, Amelie Hot, David Locht, Camille
Published in
mSystems
Bordetella pertussis regulates the production of its virulence factors by the two-component system BvgAS. In the virulence phase, BvgS phosphorylates BvgA, which then activates the transcription of virulence-activated genes (vags). In the avirulence phase, such as during growth in the presence of MgSO4, BvgA is not phosphorylated and the vags are n...
Bettencourt, Conceição Piras, Ignazio S. Foti, Sandrine C. Talboom, Joshua Miki, Yasuo Lashley, Tammaryn Balazs, Robert Viré, Emmanuelle Warner, Thomas T. Huentelman, Matt J.
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Published in
Acta Neuropathologica Communications
Cruz-Saavedra, Lissa Muñoz, Marina Patiño, Luz Helena Vallejo, Gustavo A. Guhl, Felipe Ramírez, Juan David
Published in
Parasites & Vectors
BackgroundSevere changes in temperature can affect the behavior and ecology of some infectious agents. Trypanosoma cruzi is a protozoan that causes Chagas disease. This parasite has high genetic variability and can be divided into six discrete typing units (DTUs). Trypanosoma cruzi also has a complex life-cycle, which includes the process of metacy...
Ziemys, Arturas Kim, Michelle Menzies, Alexander M Wilmott, James S Long, Georgina V Scolyer, Richard A Kwong, Larry Holder, Ashley Boland, Genevieve
Published in
Frontiers in oncology
Metastatic melanoma is one of the most immunogenic malignancies due to its high rate of mutations and neoantigen formation. Response to BRAF inhibitors (BRAFi) may be determined by intratumoral immune activation within melanoma metastases. To evaluate whether CD8+ T cell infiltration and distribution within melanoma metastases can predict clinical ...
Prokop, Jeremy W. Chhetri, Surya B. van Veen, J. Edward Chen, Xuqi Underwood, Adam C. Uhl, Katie Dwinell, Melinda R. Geurts, Aron M. Correa, Stephanie M. Arnold, Arthur P.
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Biology of Sex Differences
BackgroundThe commonly used laboratory rat, Rattus norvegicus, is unique in having multiple Sry gene copies found on the Y chromosome, with different copies encoding amino acid variations that influence the resulting protein function. It is not clear which Sry genes are expressed at the onset of testis differentiation or how their expression correl...
