Hixson, Kathryn M. Cogswell, Meaghan Brooks-Kayal, Amy R. Russek, Shelley J.
Published in
BMC Genomics
BackgroundBrain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and memory, and cognition. While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen activated protein kinase (MAPK)...
Ballerini, Evangeline S. Kramer, Elena M. Hodges, Scott A.
Published in
BMC Genomics
BackgroundPetal nectar spurs, which facilitate pollination through animal attraction and pollen placement, represent a key innovation promoting diversification in the genus Aquilegia (Ranunculaceae). Identifying the genetic components that contribute to the development of these three-dimensional structures will inform our understanding of the numbe...
Avila de Dios, Emmanuel Delaye, Luis Simpson, June
Published in
BMC Genomics
BackgroundReliable indicators for the onset of flowering are not available for most perennial monocarpic species, representing a drawback for crops such as bamboo, agave and banana. The ability to predict and control the transition to the reproductive stage in A. tequilana would represent an advantage for field management of agaves for tequila prod...
Denes, Lance T. Riley, Lance A. Mijares, Joseph R. Arboleda, Juan D. McKee, Kendra Esser, Karyn A. Wang, Eric T.
Published in
Skeletal Muscle
BackgroundSkeletal muscle contributes to roughly 40% of lean body mass, and its loss contributes to morbidity and mortality in a variety of pathogenic conditions. Significant insights into muscle function have been made using cultured cells, in particular, the C2C12 myoblast line. However, differentiation of these cells in vitro typically yields im...
Moore, Stephen G. Ericsson, Aaron C. Behura, Susanta K. Lamberson, William R. Evans, Timothy J. McCabe, Matthew S. Poock, Scott E. Lucy, Matthew C.
Published in
BMC Genomics
BackgroundFertility in dairy cows depends on ovarian cyclicity and on uterine involution. Ovarian cyclicity and uterine involution are delayed when there is uterine dysbiosis (overgrowth of pathogenic bacteria). Fertility in dairy cows may involve a mechanism through which the uterine microbiota affects ovarian cyclicity as well as the transcriptom...
Del-Aguila, Jorge L. Benitez, Bruno A. Li, Zeran Dube, Umber Mihindukulasuriya, Kathie A. Budde, John P. Farias, Fabiana H. G. Fernández, Maria Victoria Ibanez, Laura Jiang, Shan
...
Published in
Molecular Neurodegeneration
BackgroundLow frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exhibit differential CSF TREM2 levels. TREM2 has three different alternative transcripts, but most of the functio...
sasuclark, alexandru r. khadka, vedbar s. pitts, matthew w.
Selenoproteins are a unique class of proteins that play key roles in redox signaling in the brain. This unique organ is comprised of a wide variety of cell types that includes excitatory neurons, inhibitory neurons, astrocytes, microglia, and oligodendrocytes. Whereas selenoproteins are known to be required for neural development and function, the ...
Korostynski, Michal Piechota, Marcin Morga, Rafal Hoinkis, Dzesika Golda, Slawomir Zygmunt, Magdalena Dziedzic, Tomasz Moskala, Marek Slowik, Agnieszka Pera, Joanna
...
Published in
Journal of Translational Medicine
BackgroundRupture of an intracranial aneurysm (IA) causes a systemic response that involves an immune/inflammatory reaction. Our previous study revealed a downregulation of genes related to T lymphocytes and an upregulation of genes related to monocytes and neutrophils after IA rupture. It remains unknown whether that resulted from alterations in t...
Haddad, Cylia Trouverie, Jacques Arkoun, Mustapha Yvin, Jean-Claude CAIUS, José Brunaud, Véronique LAINE, Philippe Etienne, Philippe
Modulation of gene expression in roots of Brassica napus by silicon (Si) supply could allow plants to cope with future stresses.The origin of the beneficial effects of silicon (Si) in plants, especially when they are subject to stress, remains poorly understood. Some authors have shown that Si alleviates plant stress and consider that this is mainl...
reed, kent m. mendoza, kristelle m. coulombe, roger a.
Susceptibility and/or resistance to aflatoxin B1 (AFB1) is a threshold trait governed principally by glutathione S transferase (GST)-mediated detoxification. In poultry, domesticated turkeys are highly sensitive to AFB1, most likely due to dysfunction in hepatic GSTs. In contrast, wild turkeys are comparatively resistant to aflatoxicosis due to the...
