Mease, Philip Coates, Laura C Helliwell, Philip S Stanislavchuk, Mykola Rychlewska-Hanczewska, Anna Dudek, Anna Abi-Saab, Walid Tasset, Chantal Meuleners, Luc Harrison, Pille
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Published in
Lancet (London, England)
The Janus kinase 1 (JAK1) pathway has been implicated in the pathogenesis of psoriatic arthritis. We aimed to investigate the efficacy and safety of filgotinib, a selective JAK1 inhibitor, for the treatment of psoriatic arthritis. The EQUATOR trial was a randomised, double-blind, placebo-controlled phase 2 trial that enrolled adults from 25 sites i...
Cambré, Isabelle Gaublomme, Djoere Burssens, Arne Jacques, Peggy Schryvers, Nadia De Muynck, Amélie Meuris, Leander Lambrecht, Stijn Carter, Shea De Bleser, Pieter
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Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints. The reason behind the regional and patchy distribution of arthritis represents a longstanding paradox. Here we show that biomechanical loading acts as a decisive factor in the transition from systemic autoimmunity ...
Haeuser, Winfried; Finn, David P; Kalso, Eija; Krcevski-Skvarc, Nevenka; Kress, Hans-Georg; Morlion, Bart; 44030; Perrot, Serge; Schaefer, Michael; Wells, Chris; Brill, Silviu;
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Cannabis-based medicines are being approved for pain management in an increasing number of European countries. There are uncertainties and controversies on the role and appropriate use of cannabis-based medicines for the management of chronic pain. EFIC convened a European group of experts, drawn from a diverse range of basic science and relevant c...
Winthrop, Kevin L; Melmed, Gil Y; Vermeire, Severine; 3938; Long, Millie D; Chan, Gary; Pedersen, Ronald D; Lawendy, Nervin; Thorpe, Andrew J; Nduaka, Chudy; Su, Chinyu;
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Background: Tofacitinib is an oral, small molecule Janus kinase inhibitor that is being investigated for ulcerative colitis (UC). Tofacitinib is approved for rheumatoid arthritis and psoriatic arthritis, where it has been shown to increase herpes zoster (HZ) risk. We evaluated HZ risk among UC patients using tofacitinib. Methods: HZ cases were iden...
Kristensen, Lars Erik; Alten, Rieke; Puig, Luis; Philipp, Sandra; Kvien, Tore K; Mangues, Maria Antonia; van den Hoogen, Frank; Pavelka, Karel; Vulto, Arnold G; 115362;
The nocebo effect is defined as the incitement or the worsening of symptoms induced by any negative attitude from non-pharmacological therapeutic intervention, sham, or active therapies. When a patient anticipates a negative effect associated with an intervention, medication or change in medication, they may then experience either an increase in th...
Farahi, Neda Loutsios, Chrystalla Tregay, Nicola Summers, Charlotte Lok, Laurence S C Ruparelia, Prina Solanki, Chandra K Gillett, Daniel Chilvers, Edwin R Peters, A Michael
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Published in
British medical bulletin
Radionuclides for leucocyte kinetic studies have progressed from non-gamma emitting cell-labelling radionuclides through gamma emitting nuclides that allow imaging of leucocyte kinetics, to the next goal of positron emission tomography (PET). Mostly the authors' own studies, following on from studies of the early pioneers. From early imaging studie...
Marcelis, Lukas; 109931; Berghen, Charlien; 117246; De Zutter, Alexandra; 117351; Biesemans, Pauline; Vandenberghe, Peter; 5254; Verhoef, Gregor; 3176; Gheysens, Olivier; 46725; Sagaert, Xavier; 40955; Dierickx, Daan; 49763; Tousseyn, Thomas; 42009;
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Ongoing development of new drugs, as well as novel indications in the treatment of autoimmune diseases leads to the increasing use of immunomodulatory and immunosuppressive drugs. Immunomodulatory agent-related lymphoproliferative disorders are a known and potentially life threatening complication of chronic administration of these drugs, but are l...
Ekdahl, Anja Weidolf, Lars Baginski, Matthew Morikawa, Yoshio Thompson, Richard A. Wilson, Ian D.
Published in
Archives of Toxicology
The metabolic fate of the human hepatotoxin fenclozic acid ([2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid) (Myalex) was studied in normal and bile-cannulated chimeric mice with a humanized liver, following oral administration of 10 mg/kg. This in vivo animal model was investigated to assess its utility to study “human” metabolism of fenclozic ac...
chiesa, enrica pisani, silvia colzani, barbara dorati, rossella conti, bice modena, tiziana braekmans, kevin genta, ida
Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-co-glycolide (PLGA)-based conjugate was used to prepare smart nanoparticles (NPs) intended for intra-articular administration and for sel...
Lansdown, Alan B G
Published in
Critical reviews in toxicology
Gold is ubiquitous in the human environment and most people are in contact with it through wearing jewelry, dental devices, implants or therapies for rheumatoid arthritis. Gold is not a nutrient but people are exposed to it as a food colorant and in food chains. The present review discusses the hazards faced in personal and domestic use of gold and...
