Goudman, Lisa Huysmans, Eva Ickmans, Kelly Nijs, Jo Moens, Maarten Putman, Koen Buyl, Ronald Louw, Adriaan Logghe, Tine Coppieters, Iris
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Published in
Physical therapy
Around 20% of patients undergoing surgery for lumbar radiculopathy develop chronic pain after surgery, leading to high socioeconomic burden. Current perioperative interventions, including education and rehabilitation, are not always effective in preventing prolonged or chronic postoperative pain and disability. Here, a shift in educational interven...
Cambré, Isabelle Gaublomme, Djoere Schryvers, Nadia Lambrecht, Stijn Lories, Rik Venken, Koen Elewaut, Dirk
Published in
Annals of the rheumatic diseases
The mechanisms driving onset of joint inflammation in arthritides such as rheumatoid arthritis and spondyloarthritis and the conversion to disease chronicity are poorly understood. We hypothesised mechanostrain could play an instrumental role herein by engaging local and/or systemic pathways, thereby attenuating disease course and outcome. The deve...
Van Gorp, Hanne Lamkanfi, Mohamed
Published in
EMBO reports
In addition to the genomic alterations that occur in malignant cells, the immune system is increasingly appreciated as a critical axis that regulates the rise of neoplasms and the development of primary tumours and metastases. The interaction between inflammatory cell infiltrates and stromal cells in the tumour microenvironment is complex, with inf...
Dreesen, Erwin; 64069; Gils, Ann; 5633;
BACKGROUND: Psoriasis, psoriatic arthritis, spondyloarthritis, rheumatoid arthritis, ulcerative colitis and Crohn's disease share similar underlying pathophysiological processes, providing the opportunity to treat the patients using similar biological therapies. Failure of biological treatments due to underexposure can be managed by therapeutic dru...
Sanghera, C Wong, LM Panahi, M Sintou, A Hasham, M Sattler, S
Patients suffering from systemic autoimmune diseases are at significant risk of cardiovascular complications. This can be due to systemically increased levels of inflammation leading to accelerated atherosclerosis, or due to direct damage to the tissues and cells of the heart. Cardiac complications include an increased risk of myocardial infarction...
Lee, Byunghyuk Jo, Yuna Kim, Geona Ali, Laraib Amir Sohn, Dong Hyun Lee, Seung-Geun Kim, Kiseok Shin, Euisu Ryu, Sung Ho Hong, Changwan
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IL-17 produced by Th17 cells has been implicated in the pathogenesis of rheumatoid arthritis (RA). It is important to prevent the differentiation of Th17 cells in RA. Homodimeric soluble gamma c (s gamma c) impairs IL-2 signaling and enhances Th17 differentiation. Thus, we aimed to block the functions of s gamma c by inhibiting the formation of hom...
Zhou, J Li, H Xia, X Herrera, A Pollock, N Reebye, V Sodergren, MH Dorman, S Littman, BH Doogan, D
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Excessive or inappropriate inflammatory responses can cause serious and even fatal diseases. The CCAAT/enhancer-binding protein alpha (CEBPA) gene encodes C/EBPα, a transcription factor that plays a fundamental role in controlling maturation of the myeloid lineage and is also expressed during the late phase of inflammatory responses when signs of i...
Strand, Vibeke; de Vlam, Kurt; 58508; Covarrubias-Cobos, Jose A; Mease, Philip J; Gladman, Dafna D; Graham, Daniela; Wang, Cunshan; Cappelleri, Joseph C; Hendrikx, Thijs; Hsu, Ming-Ann;
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Objectives: Tofacitinib is an oral Janus kinase inhibitor for treatment of psoriatic arthritis (PsA). We evaluated patient-reported outcomes (PROs) in patients with PsA refractory to ≥1 conventional synthetic disease-modifying antirheumatic drug (csDMARD-IR) and tumour necrosis factor inhibitor-naïve in a 12-month, phase III randomised controlled t...
Arandjelovic, Sanja Perry, Justin S. A. Lucas, Christopher D. Penberthy, Kristen K. Kim, Tae-Hyoun Zhou, Ming Rosen, Dorian A Chuang, Tzu-Ying Bettina, Alexandra M. Shankman, Laura S.
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Published in
Nature Immunology
ELMO1 is a protein centrally involved in controlling the engulfment of apoptotic cells. Ravichandran and colleagues demonstrate a noncanonical role for ELMO1 in the promotion of neutrophil migration and inflammatory arthritis.
Strand, Vibeke; de Vlam, Kurt; 58508; Covarrubias-Cobos, Jose A; Mease, Philip J; Gladman, Dafna D; Chen, Linda; Kudlacz, Elizabeth; Wu, Joseph; Cappelleri, Joseph C; Hendrikx, Thijs;
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Objectives: Tofacitinib is an oral Janus kinase inhibitor for treatment of psoriatic arthritis (PsA). Patient-reported outcomes (PROs) were evaluated in patients with PsA with inadequate responses to tumour necrosis factor inhibitors (TNFi-IR) in a 6-month, phase III randomised controlled trial (OPAL Beyond [NCT01882439]). Methods: Patients (N=394)...
