Hemke, Robert Herregods, Nele Jaremko, Jacob L Åström, Gunnar Avenarius, Derk Becce, Fabio Bielecki, Dennis K Boesen, Mikael Dalili, Danoob Giraudo, Chiara
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Published in
European radiology
Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatic disease. It represents a group of heterogenous inflammatory disorders with unknown origin and is a diagnosis of exclusion in which imaging plays an important role. JIA is defined as arthritis of one or more joints that begins before the age of 16 years, persists for more th...
Lovell, Daniel J Brunner, Hermine I Reiff, Andreas O Jung, Lawrence Jarosova, Katerina Němcová, Dana Mouy, Richard Sandborg, Christy Bohnsack, John F Elewaut, Dirk
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Published in
RMD Open
Objectives Long-term safety and efficacy of adalimumab among patients with juvenile idiopathic arthritis (JIA) was evaluated through 6 years of treatment. Methods Children aged 4–17 years with polyarticular JIA were enrolled in a phase III, randomised-withdrawal, double-blind, placebo-controlled trial consisting of a 16-week open-label lead-in peri...
Gracey, Eric Burssens, Arne Cambré, Isabelle Schett, Georg Lories, Rik McInnes, Iain B. Asahara, Hiroshi Elewaut, Dirk
Published in
Nature Reviews Rheumatology
Mechanical loading is a biological stressor that elicits a homeostatic response to ensure the health and survival of the cells and/or tissues it is applied to. Tissues that encounter high amounts of mechanical stress are prone to damage, especially the tendon and ligament entheses.The immune system is crucial in responding to and orchestrating the ...
Malfait, Thomas; Emonds, Marie-Paule; 40733; Daniels, Liesbeth; Nagler, Evi V; Van Biesen, Wim; Van Laecke, Steven;
BACKGROUND: The negative role of HLA class II donor-specific antibody on graft outcome is well recognized. However, the potentially negative cardiovascular effects of preformed HLA class II antibodies and donor HLA in kidney transplant recipients (KTRs) remain unestablished. METHODS: We conducted a single-center, retrospective cohort study includin...
Malfait, Thomas Emonds, Marie-Paule Daniëls, Liesbeth Nagler, Evi V Van Biesen, Wim Van Laecke, Steven
Published in
Transplantation
The negative role of HLA class II donor-specific antibody on graft outcome is well recognized. However, the potentially negative cardiovascular effects of preformed HLA class II antibodies and donor HLA in kidney transplant recipients (KTRs) remain unestablished. We conducted a single-center, retrospective cohort study including 1115 KTRs (2003-201...
Salas, Azucena; Hernandez-Rocha, Cristian; Duijvestein, Marjolijn; Faubion, William; McGovern, Dermot; Vermeire, Severine; 3938; Vetrano, Stefania; Vande Casteele, Niels;
Cytokines are involved in intestinal homeostasis and pathological processes associated with inflammatory bowel disease (IBD). The biological effects of cytokines, including several involved in the pathology of Crohn's disease and ulcerative colitis, occur as a result of receptor-mediated signalling through the Janus kinase (JAK) and signal transduc...
Elma, Ömer Yilmaz, Sevilay Tümkaya Deliens, Tom Coppieters, Iris Clarys, Peter Nijs, Jo Malfliet, Anneleen
Published in
Journal of Clinical Medicine
Dietary patterns may play an important role in musculoskeletal well-being. However, the link between dietary patterns, the components of patients’ diet, and chronic musculoskeletal pain remains unclear. Therefore, the purpose of this review was to systematically review the literature on the link between dietary patterns, the components of patients’...
Ratitch, Bohdana; Goel, Niti; Mallinckrodt, Craig; Bell, James; Bartlett, Jonathan W; Molenberghs, Geert; 56633; Singh, Pritibha; Lipkovich, Ilya; O'Kelly, Michael;
This paper provides examples of defining estimands in real-world scenarios following ICH E9(R1) guidelines. Detailed discussions on choosing the estimands and estimators can be found in our companion papers. Three scenarios of increasing complexity are illustrated. The first example is a proof-of-concept trial in major depressive disorder where the...
Gracey, Eric; Burssens, Arne; Cambre, Isabelle; Schett, Georg; Lories, Rik; 5882; McInnes, Iain B; Asahara, Hiroshi; Elewaut, Dirk;
Mechanical loading is an important factor in musculoskeletal health and disease. Tendons and ligaments require physiological levels of mechanical loading to develop and maintain their tissue architecture, a process that is achieved at the cellular level through mechanotransduction-mediated fine tuning of the extracellular matrix by tendon and ligam...
Mittinty, Manasi M Kindt, Sara Mittinty, Murthy N Bernardes, Sonia Cano, Annmarie Verhofstadt, Lesley Goubert, Liesbet
Published in
Pain medicine (Malden, Mass.)
Dyadic coping is a process of coping within couples that is intended not only to support the patient with chronic pain but also to maintain equilibrium in the relationship. This study aims to investigate the effect of patient-perceived and spouse-reported dyadic coping on both the patient and their partner's relationship quality and anxiety, stress...
