Published in Neuromuscular disorders : NMD
Types 1 and 2 myotonic dystrophy are neuromuscular disorders caused by genomic expansions of simple sequence repeats. These mutations are unstable in somatic cells, which leads to an age-dependent increase of expansion length. Studies to determine whether changes in repeat size may influence disease severity are limited by the small amount of DNA t...
bitstream/item/209927/1/digitalizar0300.pdf / Suplemento. Palestra apresentada no 42. Congresso Brasileiro de Fitopatologia, Rio de Janeiro.
Published in Nature structural & molecular biology
Histone variant H2A.Z has a conserved role in genome stability, although it remains unclear how this is mediated. Here we demonstrate in fission yeast that the Swr1 ATPase inserts H2A.Z (Pht1) into chromatin and Kat5 acetyltransferase (Mst1) acetylates it. Deletion or unacetylatable mutation of Pht1 leads to genome instability, primarily caused by ...
Ocean wind waves represent the atmosphere-ocean boundary, playing a central role in the air-sea exchanging processes. Heat, mass and momentum are transferred across this boundary, with waves mediating the exchange of principally the momentum between the winds and the ocean surface. During the generation process waves are called wind sea. When they ...
Published in Archives of Pharmacal Research
We previously reported that arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan isolated from Forsythia koreana, exhibits anti-inflammatory, antioxidant, and analgesic effects in animal models. In addition, arctigenin inhibited eosinophil peroxidase and activated myeloperoxidase in inflamed tissues. In this study, we tested the effects of ar...
Published in Viruses
Adenovirus (Ad) vectors, in particular those of the serotype 5, are highly attractive for a wide range of gene therapy, vaccine and virotherapy applications (as discussed in further detail in this issue). Wild type Ad5 virus can replicate in numerous tissue types but to use Ad vectors for therapeutic purposes the viral genome requires modification....
International audience
Free to read on publisher website Bananas are hosts to a large number of banana streak virus (BSV) species. However, diagnostic methods for BSV are inadequate because of the considerable genetic and serological diversity amongst BSV isolates and the presence of integrated BSV sequences in some banana cultivars which leads to false positives. In thi...
In today’s competitive and partly turbulent and complex environment that enterprises operate in, the need for continous improvements, not only in the area of products and services but also in the area of processes, are very central. The importance of continuous improvements within all areas of the enterprise is greater today than ever, and the spee...
The in situ proximity ligation assay (in situ PLA) is an immunoassay that enables directvisualisation of single protein targets or protein interactions in cell or tissue samples. This project revolves around designing and introducing several novel multiplexable components tobe used in conjunction with Olink Bioscience's Duolink product line. In thi...
