Sharma, Sachin Singh, Arshdeep Sharma, Sahil Sharma, Ram Singh, Jagjeet Kinarivala, Nihar Nepali, Kunal Liou, Jing P
Published in
Anti-cancer agents in medicinal chemistry
Quinoline is considered to be a privileged heterocyclic ring owing to its presence in diverse scaffolds endowed with promising activity profiles. In particular, quinoline containing compounds have exhibited substantial antiproliferative effects through the diverse mechanism of actions, which indicates that the heteroaryl unit is flexible as well as...
Mohassab, Aliaa M Hassan, Heba A Abdelhamid, Dalia Gouda, Ahmed M Youssif, Bahaa G M Tateishi, Hiroshi Fujita, Mikako Otsuka, Masami Abdel-Aziz, Mohamed
Published in
Bioorganic chemistry
New quinoline / chalcone hybrids containing 1,2,4-triazole moiety have been designed, synthesized and their structures elucidated and confirmed by various spectroscopic techniques. The designed compounds showed moderate to good activity on different NCI 60 cell lines in a single-dose assay with a growth inhibition rate ranging from 50% to 94%. Comp...
Li, Huan-Ting Zhu, Xiaoyong
Published in
Current topics in medicinal chemistry
Drug resistance is the major cause of the failure of cancer chemotherapy, so one of the most important features in developing effective cancer therapeutic strategies is to overcome drug resistance. Quinoline moiety has become one of the most privileged structural motifs in anticancer agent discovery since its derivatives possess potent activity aga...
BHARDWAJ, Nivedita CHOUDHARY, Diksha PATHANIA, Akashdeep BARANWAL, Somesh KUMAR, Pradeep
Published in
Turkish Journal of Chemistry
Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion of single-stranded viral RNA into double-stranded viral DNA.In the present study, we have desig...
Luo, Yanhong Yue, Xiuping Wei, Peng Zhou, Aijuan Kong, Xin Alimzhanova, Shyryn
Published in
The Science of the total environment
Quinoline is a critical raw material for the dye, metallurgy, pharmaceutical, rubber, and agrochemical industries, and its use poses a serious threat to human health and the ecological environment. Quinoline has carcinogenic, teratogenic and mutagenic effects on the human body through food accumulation. However, due to the steric hindrance of its b...
Mirzaei, Salimeh Eisvand, Farhad Hadizadeh, Farzin Mosaffa, Fatemeh Ghodsi, Razieh
Published in
Iranian Journal of Basic Medical Sciences
Objective(s): Microtubules have key roles in essential cellular processes such as mitosis, cell motion, and intracellular organelle transport. Increasing interest has been given to tubulin binding compounds after the introduction of taxanes into clinical oncology. The object of this study was synthesis and biological evaluation of novel 5,6,7-trime...
Ibrahim, Tarek S Hawwas, Mohamed M Taher, Ehab S Alhakamy, Nabil A Alfaleh, Mohamed A Elagawany, Mohamed Elgendy, Bahaa Zayed, Gamal M Mohamed, Mamdouh F A Abdel-Samii, Zakaria K
...
Published in
Bioorganic chemistry
PDE5 targeting represents a new and promising strategy for apoptosis induction and inhibition of tumor cell growth due to its over-expression in diverse types of human carcinomas. Accordingly, we report the synthesis of series of pyrazolo[3,4-d]pyrimidin-4-one carrying quinoline moiety (11a-r) with potential dual PDE5 inhibition and apoptotic induc...
Sruthi, Pambingal Rajan Sankar, P. Uma Saranya, Thachora Venu Anas, Saithalavi
Published in
Chemistryselect
A facile method for the synthesis of 1, 2‐dihydroquinolines from Morita‐Baylis‐Hillman Alcohols via Palladium Catalyzed Intermolecular aryl amination followed by Intramolecular Allylic amination is described. The reaction of MBH alcohols with amino compounds under optimized conditions with Pd(PPh3)2Cl2/DPPP catalytic system produced corresponding d...
Le, Thi Hong Hai Nguyen, Thi Ngoc Vinh Ngo, Tuan Cuong Le, Van Co Bui, Thi Yen Hang Da Tran, Thi Nguyen, Huu Dinh Van Meervelt, Luc
Published in
Journal of fluorescence
Starting from eugenol (4-allyl-2-methoxyphenol) three new quinoline derivatives, namely 5-bromo-7-(carboxymethoxy)-6-hydroxy-1-methylquinolin-1-ium-3-sulfonate (Q2, C12H10BrNO7S), 5-amino-7-(carboxymethoxy)-6-hydroxyquinolin-1-ium-3-sulfonate (Q4, C11H10N2O7S) and 7-(carboxymethoxy)-5,6-dihydroxylquinolin-1-ium-3-sulfonate (Q6, C11H9NO8), have been...
Le, Thi Hong Hai; Nguyen, Thi Ngoc Vinh; Ngo, Tuan Cuong; Le, Van Co; Bui, Thi Yen Hang; 121216; Da Tran, Thi; Nguyen, Huu Dinh; Van Meervelt, Luc; 14577;
Starting from eugenol (4-allyl-2-methoxyphenol) three new quinoline derivatives, namely 5-bromo-7-(carboxymethoxy)-6-hydroxy-1-methylquinolin-1-ium-3-sulfonate (Q2, C12H10BrNO7S), 5-amino-7-(carboxymethoxy)-6-hydroxyquinolin-1-ium-3-sulfonate (Q4, C11H10N2O7S) and 7-(carboxymethoxy)-5,6-dihydroxylquinolin-1-ium-3-sulfonate (Q6, C11H9NO8), have been...
