Patients with certain urological diseases were treated with BTDS at the dosage of 75-450 mg. daily for 7-30 days. Some patients were concurrently given various medicine s according to their symptoms. Some effects w e re obtained in nocturnal eruresis and cystalgia which are frequently encountered in urological practice and many kinds of treatment a...
Published in Zeitschrift für Naturforschung C
Reaction of 6-hydrazinopurine and 2-hydrazinopyrimidine with 2,2,6,6-tetramethylpiperidone-1-oxyl gives 2,2,6,6-tetramethylpiperidone- 1-oxyl-(6-purinyl)hydrazone (3b) and 2,2,6,6- tetramethylpiperidone-1-oxyl- (2-pyrimidinyl) hydrazone (4b) respectively. Compound 3b is inactive even at high dose levels against TLX/5 lymphoma and 3b and 4b are both...
Published in Zeitschrift für Naturforschung C
NMR methods have been applied to evaluation of prototropic tautomerism, N(1)H ⇌ N (3) H, in several selected pyrimidines, viz. the neutral forms of Isocytosine and 2-alkylthiopyrimidone-4, and the monoanionic forms of uracil, 5-fluorouracil and 4-thiouracil. The predominant tautomeric species of the neutral forms could be estimated only qualitative...
Published in Zeitschrift für Naturforschung B
2-Mercapto-4-amino-5-cyano-6-arylpyrimidines (1a, b), 2-hydroxy derivatives 1c, d and 2-methylmercapto derivatives 4 a, b were synthesised via the reaction of either a mixture of malononitrile and aromatic aldehyde or arylidene malononitrile with thiourea, urea and S-methylisothiourea, respectively. 1c, d could also be obtained by the action of hyd...
Published in Zeitschrift für Naturforschung C
Hydrogen atoms from the radiolysis of water at pH 1.6 add to the 5,6-double bond of pyrimidines. The preferential site of attack is the C(5) position (values in brackets) in the case of 6-methyluracil (87%), 1,3-dimethyluracil (71%), uracil (69%) and poly(U) (60%). This reaction yields a radical of reducing properties which can be monitored by its...
Published in Zeitschrift für Naturforschung B
In the presence of alkali and LAuCl one or two -NH - groups of a purine or pyrimidine base can be transformed into - N(AuL)- groups giving stable and soluble compounds containing one or two two-coordinated gold(I) nuclei; mononuclear LAu - Q' or binuclear LAu - Q - AuL with a monodentate Q'- or an exobidentate O-- ligand, resp. (Q'H = adenine, guan...
