Published in BBA - Biomembranes
We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase α-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5% α1, 15% α2 and 22.5% α3 on average. There was an increase in expression of the α3 isoform in samples from failing hearts, but expression of all three isoforms decreas...
Objectives: To examine whether preoperative heart failure end cardiac surgery influence nitric oxide production and atrial natriuretic peptide (ANP) biological activity in infants and whether nitric oxide and ANP participate in the control of postoperative pulmonary vascular tone. Design: Prospective, clinical study. Setting: Tertiary pediatric car...
Published in The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
This report details the case of a 42-year-old homosexual Caucasian male with infection due to human immunodeficiency virus type 1 (HIV-1) who presented with a four-month history of progressive dyspnea and was found to have clinical and hemodynamic evidence of severe pulmonary hypertension. He had had no opportunistic infections, and had a T helper ...
Published in Intensive Care Medicine
Objectives: To investigate the value of extracorporeal circulatory life support (ECLS) in paediatric patients with severe Bordetella pertussis infection. Design: Single case report and a review of the ECLS database. Setting: Tertiary referral hospital paediatric intensive care unit. Patients and participants: A single case report of an infant with ...
Published in Respiration
Recent studies suggest that nitric oxide (NO) may play an important role in the pathophysiology of pulmonary hypertension. Nitroglycerin is metabolized to NO, which is a potent vascular smooth muscle relaxant. The aim of the present study was to compare the effects of inhaled and infused nitroglycerin on pulmonary hemodynamics and gas exchange in a...
Published in Neonatology
The interaction of two vasoactive substances, the vasodilator nitric oxide (NO) and the complex-acting peptide endothelin-1 (ET-1), may help explain the pathophysiology of pulmonary hypertension, an important part of many pulmonary disorders in neonates. To understand better the interactions of inhaled NO and ET-1, we investigated the effects of ET...
Published in Respiration
Endothelin-1 (ET-1) has been described to have crucial effects in the initiation and evolution of pulmonary hypertension (PH) secondary to cardiac disorders. However, the precise role of ET-1 in PH induced by chronic obstructive pulmonary disease (COPD) is not yet clear. The objective of this cross-sectional study was to determine the local and per...
Published in Neonatology
Six consecutive cases of persistent pulmonary hypertension of the newborn (PPHN) were treated with adenosine following failure of conventional therapy, excluding inhaled nitric oxide. A rise in arterial PO2 >20 mm Hg occurred in 5 of 6 cases within 30 min of commencing adenosine infusion. Individual maximal increases in PaO2 ranged from 31 to 131 m...
Published in Intensive Care Medicine
Objective: Inhalation of high concentrations of nitric oxide (NO) has been shown to improve gas exchange and to reduce pulmonary vascular resistance in individuals with ischemia-reperfusion injury following orthotopic lung transplantation. We assessed the cardiopulmonary effects of low doses of NO in early allograft dysfunction following lung trans...
Published in Journal of Anesthesia
PurposeThe purpose of this study was to quantify the increase in oxygen delivery (DO2) produced by nitric oxide (NO) inhalation, and to clarify whether NO inhalation might be effective in adult patients after cardiovascular surgery whether or not they have pulmonary hypertension (PH).MethodsThe study was done on 26 adult patients after cardiovascul...
