臨床的に前立腺癌が疑われる患者および前立腺癌のため治療中の患者計143名に対し経直腸的前立腺穿刺吸引細胞診と,経会陰式針生検による病理組織診を行った.1)吸引細胞診の検体採取率は,針生検による組織標本採取率と同等であり,92.3%であった.中でも未治療前立腺癌の検体採取率は95.8%と高かった.2)前立腺癌56例における吸引細胞診の正診率は75.0%であり,分化度が低いほどfalse negativeは少ない傾向にあった.良性前立腺癌疾患におけるfalse positiveは4.8%であった.3)前立腺癌に対する治療が奏効していると考えられる20例中,治療後の細胞診は高分化型は全例陰性,中等度分化型は12例中5例陽性,低分化型は全例陽性であった.治療効果なしの4例は全例陽性であった.4) 1...
A 65-year-old man was hospitalized with bloody sputum. His chest X-ray showed multiple nodules in both lung fields. Transbronchial lung biopsy demonstrated a poorly differentiated adenocarcinoma, which suggested that respiratory abnormalities might be metastatic cancer. Because he had noticed pollakisuria and dysuria, urologic consultation was soug...
Diseases of urinary organs are quite important from the standpoint of public health as the frequent cause of death, disease, defect, disability, discomfort, dissatisfaction and destitution (7D). From 1979 to 1984, 82,071 persons died from diseases of urinary organs in Japan. Of these 14.4, 11.9 and 8.5% were deaths from cancers of prostate, urinary...
Prostate cancer: Considering the stagnation in chemotherapy of prostate cancer in recent years, the following experiments were carried out to determine their clinical value. Surgical specimens from 6 patients, 2 permanent cell lines (EB 33 and PC 93) originated from human prostate cancer and a tumor line serially transplanted in nude mice (PC-NCC) ...
Prostate-specific antigen (PA), gamma-seminoprotein (gamma-Sm) and prostatic acid phosphatase (PAP) have been evaluated in patients with prostate cancer, benign prostatic hyperplasia (BPH), chronic prostatitis and acute prostatitis. PA has proved to be diagnostically more sensitive than PAP and gamma-Sm for the detection of prostatic cancer. Althou...
External beam radiotherapy is commonly prescribed for prostate cancer. Although new radiation techniques allow high doses to be delivered to the target, the surrounding healthy organs (rectum and bladder) may suffer from irradiation, which might produce undesirable side-effects. Hence, the understanding of the complex toxicity dose-volume effect re...
The pretreatment bone scans on 40 patients with prostate cancer with bone involvement were reviewed and the prognostic impact of the initial extent of bone metastasis was evaluated. On the bases of the number or extent of bone metastasis, the patients were divided into 2 groups and survival for each group was compared. We also assessed the correlat...
We compared the values obtained by double-antibody radioimmunoassay (RIA) and immunoenzyme assay (IEA) for measuring the prostatic acid phosphatase (PAP) in human serum. Mean PAP value of IEA in normal persons was 0.582 +/- 0.228 ng/ml (M+2SD, 1.038 ng/ml). Correction of two methods in benign prostatic hypertrophy (BPH) and prostate cancer patients...
A prostate mass screening was performed in 6 towns in Shiribeshi area in Hokkaido Prefecture on 384 males who were over 50 years old. The screening included digital palpation, uroflowmetry, blood sampling for tumor markers, questionnaire for voiding disturbances and transrectal sonography. Prostatic carcinoma was found in 9 (2.3%) of 384 males. An ...
初回治療として内分泌療法を施行した病期D2前立腺癌120例について,PAP, γ-SmおよびPSA値と予後およびマーカー併用の有用性を検討した.1)治療前マーカー値の高低と予後とは,PAP, γ-SmおよびPSA共関連が認められなかった.2) PAPおよびγ-Smにおいては,内分泌療法後3ヵ月および6ヵ月の時点で,マーカーが異常値にとどまるものの予後は正常化したものより不良であった.ただし,1ヵ月後ではこの関連がみられなかった.3)内分泌療法後3ヵ月の時点で,PAPが正常化したもののうち癌死例があるが,これらの大多数はγ-Smは異常値にとどまっていた.したがって,両マーカーの併用により,よりよく予後を推測できる.4)低分化腺癌で,内分泌療法後3ヵ月でマーカー正常化の有無は予後に差があり,正常...
