Yang, Dae-Myoung Li, Fiona Bauman, Glenn Chin, Joseph Pautler, Stephen Moussa, Madeleine Rachinsky, Irina Valliant, John Lee, Ting-Yim
Published in
EJNMMI Research
PurposeIdentification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), is better than choline-based [18F]FCH (fluorocholine) i...
Tian, Hao Chou, Fu-ju Tian, Jing Zhang, Yong You, Bosen Huang, Chi-Ping Yeh, Shuyuan Niu, Yuanjie Chang, Chawnshang
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundEarly studies indicated that ASC-J9®, an androgen receptor (AR) degradation enhancer, could suppress the prostate cancer (PCa) progression. Here we found ASC-J9® could also suppress the PCa progression via an AR-independent mechanism, which might involve modulating the tumor suppressor ATF3 expression.MethodsThe lentiviral system was used...
Mustafa, Mahmoud Rass, Honood Abu Yahya, Mothafr Hamdan, Khaleel Eiss, Yazan
Published in
World Journal of Surgical Oncology
PurposeTo define the efficacy of standard androgen deprivation therapy (ADT) in the treatment of metastatic prostate cancer (PCa).Materials and methodsFifty patients with mean age of 70.48 ± 9.95 years old (range 52–87) who had metastatic PCa and received ADT between 2014 and 2019 were retrospectively evaluated. Median values of pre-therapeutic PSA...
Qi, Jin-Chun Yang, Zhan Lin, Tao Ma, Long Wang, Ya-Xuan Zhang, Yong Gao, Chun-Cheng Liu, Kai-Long Li, Wei Zhao, An-Ning
...
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundBoth E2F transcription factor and cyclin-dependent kinases (CDKs), which increase or decrease E2F activity by phosphorylating E2F or its partner, are involved in the control of cell proliferation, and some circRNAs and miRNAs regulate the expression of E2F and CDKs. However, little is known about whether dysregulation among E2Fs, CDKs, ci...
Lu, Yu-Cheng Huang, Chao-Yuan Lu, Yu-Chuan Huang, Kuo-How Chow, Po-Ming Chang, Yi-Kai Hung, Fan-Ching Chen, Chung-Hsin Jaw, Fu-Shan Hong, Jian-Hua
...
Published in
Journal of the Formosan Medical Association = Taiwan yi zhi
In advanced or high-grade prostate cancer (PCa), prostate-specific antigen (PSA) is usually elevated, however, some patients may present with low initial PSA (iPSA) levels. The objective of this study was to evaluate whether different iPSA levels were associated with dissimilar clinical outcomes among men with high-grade PCa and advanced disease af...
Yamaguchi, Masayoshi Osuka, Satoru Murata, Tomiyasu Ramos, Joe W
Published in
Translational oncology
Prostate cancer, which is a bone metastatic cancer, is the second leading cause of cancer-related death in men. There is no effective treatment for metastatic prostate cancer. Regucalcin has been shown to contribute as a suppressor in various types of human cancers. In the present study, furthermore, we investigate an involvement of regucalcin in s...
Adawi, Essa A
Published in
Urology case reports
A metastatic disease causes jaundice is not uncommon and usually related to direct tumor invasion to the biliary tree or massive intrahepatic metastasis. Cholestasis secondary to non-traumatic intrahepatic bleeding caused by metastasis from prostate cancer is never been reported in the literature. We present the first case of a-71-years-old patient...
Risdon, Emily N Chau, Cindy H Price, Douglas K Sartor, Oliver Figg, William D
Published in
The oncologist
The U.S. Food and Drug Administration recently approved two poly-adenosine diphosphate-ribose polymerase (PARP) inhibitors, olaparib and rucaparib, for treatment of biomarker-positive metastatic castrate resistant prostate cancer. The benefits of PARP inhibition have been well characterized in patients who have BRCA1 and BRCA2 mutations in several ...
Duan, Qingxia Li, Xinna He, Xiaozhou Shen, Xinxin Cao, Yu Zhang, Ruiqing Bai, Xueding Zhang, Jinyan Ma, Xuejun
Single nucleotide polymorphisms (SNPs) have important application value in the research of population genetics, hereditary diseases, tumors, and drug development. Conventional methods for detecting SNPs are typically based on PCR or DNA sequencing, which is time-consuming, costly, and requires complex instrumentation. In this study, we present a du...
Niture, Suryakant Lin, Minghui Odera, Joab O Moore, John Zhe, Hong Chen, Xiaoxin Suy, Simeng Collins, Sean P Kumar, Deepak
Published in
The international journal of biochemistry & cell biology
Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of TIPE/TNFAIP8 family, has been involved in the development and progression of various human cancers. We hypothesized that TNFAIP8 promotes prostate cancer (PCa) progression via regulation of oxidative phosphorylation (OXPHOS) and glycolysis. Ectopic expression of TNFAIP8 increased PC...
