Yamaguchi, Masayoshi Osuka, Satoru Murata, Tomiyasu Ramos, Joe W
Published in
Translational oncology
Prostate cancer, which is a bone metastatic cancer, is the second leading cause of cancer-related death in men. There is no effective treatment for metastatic prostate cancer. Regucalcin has been shown to contribute as a suppressor in various types of human cancers. In the present study, furthermore, we investigate an involvement of regucalcin in s...
Adawi, Essa A
Published in
Urology case reports
A metastatic disease causes jaundice is not uncommon and usually related to direct tumor invasion to the biliary tree or massive intrahepatic metastasis. Cholestasis secondary to non-traumatic intrahepatic bleeding caused by metastasis from prostate cancer is never been reported in the literature. We present the first case of a-71-years-old patient...
Risdon, Emily N Chau, Cindy H Price, Douglas K Sartor, Oliver Figg, William D
Published in
The oncologist
The U.S. Food and Drug Administration recently approved two poly-adenosine diphosphate-ribose polymerase (PARP) inhibitors, olaparib and rucaparib, for treatment of biomarker-positive metastatic castrate resistant prostate cancer. The benefits of PARP inhibition have been well characterized in patients who have BRCA1 and BRCA2 mutations in several ...
Duan, Qingxia Li, Xinna He, Xiaozhou Shen, Xinxin Cao, Yu Zhang, Ruiqing Bai, Xueding Zhang, Jinyan Ma, Xuejun
Single nucleotide polymorphisms (SNPs) have important application value in the research of population genetics, hereditary diseases, tumors, and drug development. Conventional methods for detecting SNPs are typically based on PCR or DNA sequencing, which is time-consuming, costly, and requires complex instrumentation. In this study, we present a du...
Niture, Suryakant Lin, Minghui Odera, Joab O Moore, John Zhe, Hong Chen, Xiaoxin Suy, Simeng Collins, Sean P Kumar, Deepak
Published in
The international journal of biochemistry & cell biology
Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of TIPE/TNFAIP8 family, has been involved in the development and progression of various human cancers. We hypothesized that TNFAIP8 promotes prostate cancer (PCa) progression via regulation of oxidative phosphorylation (OXPHOS) and glycolysis. Ectopic expression of TNFAIP8 increased PC...
KÖditz, Barbara Stog, Andreas GÖbel, Heike Heidegger, Isabell Fries, Jochen Heidenreich, Axel VON Brandenstein, Melanie
Published in
Anticancer research
Vimentin3 (Vim3) was recently described as a tumour marker for the direct discrimination between benign and malignant kidney tumours. Here, we examined its expression in prostate cancer (PCa) cell lines and the regulation of its expression by endothelin receptors. Prostate cancer cell lines (PC3, DU145, LNCap) were incubated with endothelin 1 (ET-1...
Vlajnic, Tatjana Bubendorf, Lukas
Published in
Pathology
While localised prostate cancer can be cured by local treatment, 'high-risk' prostate cancer often progresses to castration resistant disease and remains incurable with a dismal prognosis. In recent years, technical advances and development of novel methodologies have largely contributed to a better understanding of underlying molecular mechanisms ...
Cooperberg, Matthew R Cowan, Janet E Lindquist, Karla J Kobayashi, Yasuko Simko, Jeffry P Bengtsson, Henrik Singh, Khushboo Ngo, Vy Avila, Andrew Newcomb, Lisa F
...
Published in
European urology
Distinguishing indolent from aggressive prostate cancer remains a key challenge for decision making regarding prostate cancer management. A growing number of biomarkers are now available to help address this need, but these have rarely been examined together in the same patients to determine their potentially additive value. To determine whether tw...
Shi, Zhenfeng Chen, Jie Wumaner, Aikebaier Li, Ming Liang, Chengyuan Li, Min
Published in
Biochemical and biophysical research communications
The prostate cancer (PCa) poses serious threat to men's health. The androgen receptor (AR) is essential for normal prostate development and prostate cancer progression. We identified a novel lncRNA PCLN16 which is significantly correlated with AR signaling during prostate cancer progression. The AR-regulated PCLN16 was abundantly overexpressed in l...
Connor, Martin J Dubash, Suriaya Bass, Edward J Tam, Henry Barwick, Tara Khoo, Vincent Winkler, Mathias Ahmed, Hashim U
Published in
European urology focus
Recent evidence from randomised trials supports the diagnostic superiority of prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) over conventional imaging in the detection of distant occult metastasis in men with newly diagnosed high-risk prostate cancer. This may result in a rise in the detection ...
