Menzies-Gow, Andrew Wechsler, Michael E. Brightling, Chris E.
Published in
Respiratory Research
Despite treatment with standard-of-care medications, including currently available biologic therapies, many patients with severe asthma have uncontrolled disease, which is associated with a high risk of hospitalization and high healthcare costs. Biologic therapies approved for severe asthma have indications limited to patients with either eosinophi...
Li, Yujia Li, Shilin Duan, Xiaoqiong Yang, Chunhui Xu, Min Chen, Limin
Published in
Journal of Clinical and Translational Hepatology
Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000 deaths every year. Outcomes of HBV infection depend on the interaction between the virus and host immune system. It is becoming increasingly apparent that Kupffer cells (KCs), the largest population of resident and monocyte-derived macrophages in the live...
Nystrand, M. Dowling, D. K.
Published in
BMC Biology
BackgroundLife-history theory predicts a trade-off between investment into immune defence and other fitness-related traits. Accordingly, individuals are expected to upregulate their immune response when subjected to immune challenge. However, this is predicted to come at the expense of investment into a range of other traits that are costly to main...
Fernando, Pasan C. Mabee, Paula M. Zeng, Erliang
Published in
BMC Bioinformatics
BackgroundIdentification of genes responsible for anatomical entities is a major requirement in many fields including developmental biology, medicine, and agriculture. Current wet lab techniques used for this purpose, such as gene knockout, are high in resource and time consumption. Protein–protein interaction (PPI) networks are frequently used to ...
Muir, A Gurung, I Cehovin, A Bazin, A Vallenet, D Pelicic, V
The bacterium Neisseria meningitidis causes life-threatening meningitis and sepsis. Here, we construct a complete collection of defined mutants in protein-coding genes of this organism, identifying all genes that are essential under laboratory conditions. The collection, named NeMeSys 2.0, consists of individual mutants in 1584 non-essential genes....
Kronbichler, Andreas Lee, Keum Hwa Denicolò, Sara Choi, Daeun Lee, Hyojeong Ahn, Donghyun Kim, Kang Hyun Lee, Ji Han Kim, HyungTae Hwang, Minha
...
Published in
International Journal of Molecular Sciences
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder which affects small- and, to a lesser degree, medium-sized vessels. ANCA-associated vasculitis encompasses three disease phenotypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EG...
Ren, S M Wu, Q H Jiao, Z H Chen, Y B Chen, C Kong, X D Qin, Z B
Published in
Zhonghua er ke za zhi = Chinese journal of pediatrics
目的： 探讨常染色体隐性非综合征耳聋3型致病基因MYO15A基因的变异特点及临床特征。 方法： 回顾性分析自2016年11月至2019年2月在郑州大学第一附属医院遗传与产前诊断中心进行耳聋基因高通量测序的108个非综合征型耳聋家庭的听力及测序数据，总结MYO15A基因的变异情况。 结果： 共有来自8个家庭的9例耳聋患儿检测到MYO15A基因复合杂合变异，占所有耳聋家庭的7.4%（8/108），变异位点分别为c.5910+1G>A/c.9417_9418insTA、c.4234T>G/c.8324G>T、c.3926A>T/c.5002delC、c.9690+1G>A/c.10257_10259delCTT、c.8324G>T/c.10419_10423delCAGCT、c.4519C>T/c...
Nekoee Zahraei, Halehsadat GUISSARD, Françoise Paulus, Virginie HENKET, Monique Donneau, Anne-Françoise Louis, Renaud
Chronic obstructive pulmonary disease (COPD) is a complex, multidimensional and heterogeneous disease. The main purpose of the present study was to identify clinical phenotypes through cluster nalysis in adults suffering from COPD. A retrospective study was conducted on 178 COPD patients in stable state recruited from ambulatory care at University ...
Ponsford, Mark J Gkatzionis, Apostolos Walker, Venexia M Grant, Andrew J Wootton, Robyn E Moore, Luke SP Fatumo, Segun Mason, Amy Zuber, Verena Willer, Cristen
...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Many patients with severe COVID-19 develop sepsis. Cardiometabolic traits have been associated with increased risk of severe COVID-19 and sepsis, however it is difficult to infer causal effects from observational...
Zhang, Jie Petersen, Søren D Radivojevic, Tijana Ramirez, Andrés Pérez-Manríquez, Andrés Abeliuk, Eduardo Sánchez, Benjamín J Costello, Zak Chen, Yu Fero, Michael J
...
Through advanced mechanistic modeling and the generation of large high-quality datasets, machine learning is becoming an integral part of understanding and engineering living systems. Here we show that mechanistic and machine learning models can be combined to enable accurate genotype-to-phenotype predictions. We use a genome-scale model to pinpoin...
