Wu, Linwei Yang, Yunfeng Chen, Si Jason Shi, Zhou Zhao, Mengxin Zhu, Zhenwei Yang, Sihang Qu, Yuanyuan Ma, Qiao He, Zhili
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The ecological concept of the r-K life history strategy is widely applied in macro-ecology to characterize functional traits of taxa. However, its adoption in microbial communities is limited, owing to the lack of a measureable, convenient functional trait for classification. In this study, we performed an experiment of stepwise organic amendments ...
Miller, William B Torday, John S
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition based evolution is suggested as an alternative approach to cancer development and progression in which neoplastic cells of differing karyotyp...
Sheng, Lili Jena, Prasant Kumar Hu, Ying Liu, Hui-Xin Nagar, Nidhi Kalanetra, Karen M French, Samuel William French, Samuel Wheeler Mills, David A Wan, Yu-Jui Yvonne
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Dysregulated bile acid (BA) synthesis or reduced farnesoid X receptor (FXR) levels are found in patients having metabolic diseases, autoimmune hepatitis, and liver cirrhosis or cancer. The objective of this study was to establish the relationship between butyrate and dysregulated BA synthesis-induced hepatitis as well as the effect of butyrate in r...
Liu, Dajiang J Peloso, Gina M Yu, Haojie Butterworth, Adam S Wang, Xiao Mahajan, Anubha Saleheen, Danish Emdin, Connor Alam, Dewan Alves, Alexessander Couto
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Published in
Nature genetics
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At t...
Finsterer, Josef Zarrouk-Mahjoub, Sinda
Letter to the Editor
Aschard, Hugues Guillemot, Vincent Vilhjalmsson, Bjarni Patel, Chirag J Skurnik, David Ye, Chun J Wolpin, Brian Kraft, Peter Zaitlen, Noah
Testing for associations in big data faces the problem of multiple comparisons, wherein true signals are difficult to detect on the background of all associations queried. This difficulty is particularly salient in human genetic association studies, in which phenotypic variation is often driven by numerous variants of small effect. The current stra...
Deveza, L A Melo, L Yamato, T P Mills, K Ravi, V Hunter, D J
Published in
Osteoarthritis and cartilage
To systematically review the literature for studies investigating knee osteoarthritis (OA) phenotypes to examine what OA characteristics are relevant for phenotyping. A comprehensive search was performed in Medline, EMBASE, Web of Sciences, CINAHL, and Scopus databases from inception to September 2016. Inclusion was limited to observational studies...
Obeidat, Ma'en Li, Xuan Burgess, Stephen Zhou, Guohai Fishbane, Nick Hansel, Nadia N Bossé, Yohan Joubert, Philippe Hao, Ke Nickle, David C
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SRINIVASAN, S ASHOK, V MOHANTY, S DAS, A DAS, S KUMAR, S SEN, S PURWAR, R
Recent studies have implicated the roles of cancer stem like cells (CSCs) in cancer metastasis. However, very limited knowledge exists at the molecular and cellular level to target CSCs for prevention of cancer metastasis. In this study, we examined the roles of contractile dynamics of CSCs in cell invasion and delineated the underlying molecular m...
Heintzman, Peter D Zazula, Grant D MacPhee, Ross DE Scott, Eric Cahill, James A McHorse, Brianna K Kapp, Joshua D Stiller, Mathias Wooller, Matthew J Orlando, Ludovic
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The extinct 'New World stilt-legged', or NWSL, equids constitute a perplexing group of Pleistocene horses endemic to North America. Their slender distal limb bones resemble those of Asiatic asses, such as the Persian onager. Previous palaeogenetic studies, however, have suggested a closer relationship to caballine horses than to Asiatic asses. Here...