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Abrupt changes in pentobarbital sensitivity in preBötzinger complex region, hypoglossal motor nucleus, nucleus tractus s...

Published in Respiratory physiology & neurobiology

On postnatal days P10-P15 in rat medulla, neurotransmitter receptor subunit composition shifts toward a more mature phenotype. Since medullary GABAARs regulate cardiorespiratory function, abrupt alterations in GABAergic synaptic inhibition could disrupt homeostasis. We hypothesized that GABAARs on medullary neurons become more resistant to positive...

Post-sampling release of free fatty acids - effects of heat stabilization and methods of euthanasia.

Published in Journal of pharmacological and toxicological methods

The field of lipid research has made progress and it is now possible to study the lipidome of cells and organelles. A basic requirement of a successful lipid study is adequate pre-analytical sample handling, as some lipids can be unstable and postmortem changes can cause substantial accumulation of free fatty acids (FFAs). The aim of the present st...

Anesthesia influences neuronal activity and drug effectiveness in neuropathic rats.

Published in Pain

In the study of neuropathic pain, the reduction of spinal neuronal activity by an analgesic drug can inform about site and mechanistic aspects of action. Animal experiments such as in vivo electrophysiological recordings from spinal neurons, however, largely require anesthesia. The impact of the anesthesia on the interpretation of the experimental ...

Cardioprotective effect of isoflurane anesthesia from Takotsubo syndrome and its implications.

Published in International journal of cardiology

The hepatic circadian clock modulates xenobiotic metabolism in mice

The circadian clock generates daily cycles of gene expression that regulate physiological processes. The liver plays an important role in xenobiotic metabolism and also has been shown to possess its own cell-based clock. The liver clock is synchronized by the master clock in the brain, and a portion of rhythmic gene expression can be driven by beha...

Propylene glycol-induced lactic acidosis in a child receiving a pentobarbital continuous infusion

Published in Journal of Pediatric Intensive Care

Pentobarbital (PB) contains 40% propylene glycol (PG) and could result in lactic acidosis (LA). Previous reports have indicated PG-induced LA following PB continuous infusion (CI), but there are no reports in young children. A 3-year-old male was admitted for new-onset seizures. After failing conventional therapy, he was initiated on intravenous PB...

The mesenterially perfused rat small intestine: A versatile approach for pharmacological testings

Published in Annals of Anatomy

BOLD fMRI in infants under sedation: Comparing the impact of pentobarbital and propofol on auditory and language activat...

Published in Journal of magnetic resonance imaging : JMRI

To elucidate differences in the disruption of language network function, as measured by blood oxygenation level-dependent (BOLD) contrast functional MRI (fMRI), attributable to two common sedative agents administered to infants under clinical imaging protocols. The sedatives pentobarbital (Nembutal) and Propofol, administered clinically to infants ...