Published in International Journal of Surgery Case Reports
Introduction Intracranial hypertension that is not responsive to other therapies can be managed through the use of a barbiturate induced coma. Although potentially effective, there are known complications associated with this treatment, and as such it is typically reserved for the most severe cases. One such sequela of barbiturate induced coma ther...
Published in The Veterinary clinics of North America. Small animal practice
The history of companion animal euthanasia includes a blend of good and bad methodology, the shifting landscape of the human-animal bond, and maturation of the veterinary euthanasia experience. Time has shown us that critical exploration of what once was acceptable will lead the way to modern best practices. Animal welfare remains at the heart of t...
Published in Avicenna journal of phytomedicine
Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice. The hydro-alcoholic extract (HAE) of T. parthenium and three fractions of it, namely water fraction (WF), ethyl acetate fraction (EAF), and n-hexane fraction (NHF), were intraperitoneal...
The plant world represents an important source of potential therapeutic agents, but concomitant administration of herbal and conventional medications may result in interactions with subsequent beneficial or adverse effects. This study was designed to examine the analgesic effect of thyme tincture and thyme syrup, two commonly used thyme formulation...
Published in Journal of neuroscience methods
Laboratory practice commonly implies rodent anesthesia. Such is instrumental not only for animal welfare, but also for standardized assessment of new anesthetics. We developed and validated a grading system for a temporal follow-up of anesthesia. The Minho Objective Rodent Phenotypical Anesthesia (MORPhA) scale was tested in mice (C57BL/6 J) and ra...
Published in Current drug discovery technologies
In Iranian Traditional Medicine, the herbs with cold and wet temperament can help to improve insomnia. Portulaca oleracea has a cold and wet temperament, so the present study was carried out to investigate the sleep-prolonging effect of Portulaca oleracea. This work was an experimental study on mice which were randomly divided into these groups: sa...
Published in Journal of Medical Toxicology
IntroductionPentobarbital (PB) is a euthanasia drug in doses of 2 to 10 grams, causing death within 15–30 minutes. We report a case of recovery from lethal pentobarbital deliberate self-poisoning with confirmatory serum drug concentrations.Case ReportA 45-year-old male purchased 20 grams of PB powder over the Internet. He ingested this powder and t...
Published in Pharmacological research
GABAA receptors play a dominant role in mediating inhibition in the mature mammalian brain, and defects of GABAergic neurotransmission contribute to the pathogenesis of a variety of neurological and psychiatric disorders. Two types of GABAergic inhibition have been described: αβγ receptors mediate phasic inhibition in response to transient high-con...
Published in Epilepsy & behavior case reports
A ketogenic diet (KD) may have a role in treating patients in super-refractory status epilepticus (SRSE). Sodium-glucose cotransporter 2 (SGLT2) inhibitors have a risk of ketoacidosis that could facilitate induction of KD. A 42-year-old with a history of drug resistant epilepsy developed SRSE requiring several pharmacological interventions during h...
Published in Biomolecules & therapeutics
Sinomenium acutum has been long used in the preparations of traditional medicine in Japan, China and Korea for the treatment of various disorders including rheumatism, fever, pulmonary diseases and mood disorders. Recently, it was reported that Sinomenium acutum, has sedative and anxiolytic effects mediated by GABA-ergic systems. These experiments ...
