Nakayama, Ryuichi Sato, Hiroki Yama, Naoya Ogura, Keishi Kyan, Ryoko Hanazawa, Tomoki Yoshizawa, Tomohiro Miyamoto, Masamune Kamijo, Yoshito Mizuno, Hirotoshi
...
Published in
Forensic science, medicine, and pathology
Suicide attempts in humans due to injections of the veterinary drug pentobarbital sodium have been rarely reported. Herein, we present a case of a suicide attempt by intramuscular injection of pentobarbital sodium into the rectus abdominis muscle, which was suggested by computed tomography (CT). A 73-year-old man was brought to the emergency depart...
Iannucci, Claudia Hoehne, Sabrina N Murthy, Vishal D Dutil, Guillaume Maiolini, Arianna
ObjectiveTo describe the clinical signs, electroencephalographic (EEG) findings, treatment, and outcome in a dog after successful resuscitation from out-of-hospital cardiopulmonary arrest (OHCA) induced by pentobarbital intoxication.Case summaryA 10-year-old, male intact Jack Russell Terrier was referred for management of refractory status epilepti...
Fedorov, Anton Lehto, Alina Klein, Jochen
Published in
Naunyn-Schmiedeberg's archives of pharmacology
General anesthetic drugs have been associated with various unwanted effects including an interference with mitochondrial function. We had previously observed increases of lactate formation in the mouse brain during anesthesia with volatile anesthetic agents. In the present work, we used mitochondria that were freshly isolated from mouse brain to te...
Shintani-Ishida, Kaori Idota, Nozomi Tsuboi, Hajime Tsurumi, Riko Ikegaya, Hiroshi
Published in
Legal medicine (Tokyo, Japan)
Suicides by pentobarbital overdose have increased since about 2012, which appear to be influenced by technical information on active euthanasia that has spread over the Internet. We encountered a pentobarbital poisoning case of a patient with amyotrophic lateral sclerosis. A caregiver found the patient unconscious immediately after two visitors lef...
Ahn, Yejin Kim, Singeun Park, Chunwoong Kim, Jung Eun Suh, Hyung Joo Jo, Kyungae
Published in
Pharmaceutical Biology
Context The sleep-promoting activity of Nelumbo nucifera Gaertn. (Nymphaeaceae) alkaloids in leaves or seeds are well known. However, the sleep-promoting activity of the lotus rhizome (LE), which is used mainly as food, has not yet been evaluated. Objective We investigated the sleep-promoting activity of LE water extract. Materials and methods Inst...
Kim, Yu Ri Lee, Sun Young Lee, So Min Shim, Insop Lee, Mi Young
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Treatment of sleep disorders promotes the long-term use of commercially available sleep inducers that have several adverse effects, including addiction, systemic fatigue, weakness, loss of concentration, headache, and digestive problems. Therefore, we aimed to limit these adverse effects by investigating a natural product, the extract of the Hibisc...
Cheng, Ziqian Yang, Wei Li, Bingjin Cui, Ranji
Published in
Journal of molecular neuroscience : MN
KLF4 is a zinc-finger transcription factor that plays an essential role in many biological processes, including neuroinflammation, neuron regeneration, cell proliferation, and apoptosis. Through effects on these processes, KLF4 has likely roles in Alzheimer's disease, Parkinson's disease, and traumatic brain injury. However, little is known about t...
MADADZADEH, Mohammad ABBASNEJAD, Mehdi MOLLASHAHI, Mahtab POURRAHIMI, Ali Mohammad ESMAEILI-MAHANI, Saeed
ABSTRACT Background: Sleep disorders induce anxiety and forgetfulness and change habits. The chemical hypnotic drugs currently used have serious side effects and, therefore, people are drawn towards using natural compounds such as plant-based healing agents. Abscisic acid (ABA) is produced in a variety of mammalian tissues and it is involved in man...
Rakhshandeh, Hassan Rashidi, Roghayeh Vahedi, Mohammad Mahdi Khorrami, Mohammad Bagher Abbassian, Hassan Forouzanfar, Fatemeh
Published in
Recent patents on food, nutrition & agriculture
Sleep disorders are among the most common psychiatric and medical conditions. Herbal medicine appears to be effective in the treatment of sleep disorders which have been valued by many of publications and patents. The present study aimed at investigating the hypnotic activity of the hydro-alcoholic extract of Capparis spinosa (HAE) in mice. Three d...
Lin, Yiquan Zhang, Rui Shen, Weihua Chen, Qianru Zhu, Yanling Li, Jinfei Chi, Wei Gan, Xiaoliang
Published in
Journal of clinical anesthesia
Procedural sedation for non-painful pediatric examinations outside the operating room remains a challenge, this study was designed to compare the safety and effectiveness of sedation provided by dexmedetomidine versus other sedatives including chloral hydrate, midazolam, and pentobarbital for pediatric patients to complete diagnostic examinations. ...
