Sachdev, Saachi Cucchiara, Andrew J Snyder, Peter J
Published in
Journal of the Endocrine Society
Context Clinical guidelines recommend measurement of the serum prostate-specific antigen (PSA) concentration during testosterone treatment of hypogonadal men to determine whether the increase is sufficiently high to warrant urologic referral. Prior studies of the effect of testosterone treatment on PSA concentrations have been conducted in men who ...
Lim, Syer C Jansson, Patric J Assinder, Stephen J Maleki, Sanaz Richardson, Des R Kovacevic, Zaklina
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The androgen receptor (AR) is a major driver of prostate cancer (PCa) and a key therapeutic target for AR inhibitors (ie, Enzalutamide). However, Enzalutamide only inhibits androgen-dependent AR signaling, enabling intrinsic AR activation via androgen-independent pathways, leading to aggressive castration-resistant PCa (CRPC). We investigated the a...
Viste, Eirik Vinje, Cathrine Alvaer Lid, Torgeir Gilje Skeie, Svein Evjen-Olsen, Øystein Nordström, Tobias Thorsen, Olav Gilje, Bjørnar Janssen, Emiel A M Kjosavik, Svein R
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Published in
Scandinavian journal of primary health care
To describe early experience of replacing PSA with Stockholm3 for detection of prostate cancer in primary care. Longitudinal observations, comparing outcome measures before and after the implementation of Stockholm3. Stavanger region in Norway with about 370,000 inhabitants, 304 general practitioners (GPs) in 97 primary care clinics, and one hospit...
Falagario, Ugo Jambor, Ivan Taimen, Pekka Syvänen, Kari T Kähkönen, Esa Merisaari, Harri Montoya Perez, Ileana Knaapila, Juha Steiner, Aida Verho, Janne
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Published in
World journal of urology
We aimed to develop and externally validate a nomogram based on MRI volumetric parameters and clinical information for deciding when SBx should be performed in addition to TBx in man with suspicious prostate MRI. Retrospective analyses of single (IMPROD, NCT01864135) and multi-institution (MULTI-IMPROD, NCT02241122) clinical trials. All men underwe...
Borkowetz, Angelika Lohse-Fischer, Andrea Scholze, Jana Lotzkat, Ulrike Thomas, Christian Wirth, Manfred P. Fuessel, Susanne Erdmann, Kati
Published in
Diagnostics
Currently used tumor markers for early diagnosis of prostate cancer (PCa) are often lacking sufficient specificity and sensitivity. Therefore, the diagnostic potential of selected microRNAs in comparison to serum PSA levels and PSA density (PSAD) was explored. A panel of 12 PCa-associated microRNAs was quantified by qPCR in urinary sediments from 5...
Dadgar, Habibollah Emami, Farshad Norouzbeigi, Nasim Vafaee, Manouchehr Seyedi Jafari, Esmail Gholamrezanezhad, Ali Assadi, Majid Ahmadzadehfar, Hojjat
Published in
Molecular imaging and biology
The early and accurate diagnosis of locoregional recurrence or metastasis in prostate cancer (PC) has a significant impact on treatment options. Prostatic-specific membrane antigen (PSMA) positron emission tomography (PET)/x-ray computed tomograph (CT) imaging has recently been introduced as a novel procedure in managing PC. The aim of this study w...
Busetto, Gian Maria Del Giudice, Francesco Maggi, Martina De Marco, Ferdinando Porreca, Angelo Sperduti, Isabella Magliocca, Fabio Massimo Salciccia, Stefano Chung, Benjamin I De Berardinis, Ettore
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Published in
World journal of urology
To evaluate the diagnostic accuracy of SelectMDx and its association with multiparametric magnetic resonance (mpMRI) in predicting prostate cancer (PCa) and clinically significant PCa (csPCa) on prostate biopsies among men scheduled for initial prostate biopsy. In this single-center prospective study, 52 men scheduled for initial prostate biopsy, b...
Woźnicki, Piotr Westhoff, Niklas Huber, Thomas Riffel, Philipp Froelich, Matthias F. Gresser, Eva von Hardenberg, Jost Mühlberg, Alexander Michel, Maurice Stephan Schoenberg, Stefan O.
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Published in
Cancers
Radiomics is an emerging field of image analysis with potential applications in patient risk stratification. This study developed and evaluated machine learning models using quantitative radiomic features extracted from multiparametric magnetic resonance imaging (mpMRI) to detect and classify prostate cancer (PCa). In total, 191 patients that under...
Yanai, Yoshinori Matsumoto, Kazuhiro Kosaka, Takeo Takeda, Toshikazu Tanaka, Nobuyuki Morita, Shinya Mizuno, Ryuichi Shinojima, Toshiaki Asanuma, Hiroshi Oya, Mototsugu
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Published in
International journal of clinical oncology
Biochemical recurrence (BCR) after radical prostatectomy (RP) is most commonly diagnosed by detecting an increase in asymptomatic prostate-specific antigen (PSA). We previously reported the "optimal PSA follow-up schedule after RP". The aim of this study was to confirm the usefulness and safety of that follow-up schedule in another cohort. We retro...
Yang, Daijun Shi, Xiang Lei, Yu Zhou, Xianrong Chen, Qiuxiang
Published in
Oncology Letters
Prostate cancer (PCa) is one of the most common types of malignant tumor, which places a major burden on the health of men, worldwide. A prerequisite to ensure good treatment outcomes for patients with PCa is an accurate diagnosis. The present study aimed to investigate the diagnostic value of prostate-specific antigen (PSA) and α-methylacyl-CoA ra...
