Basilicata, M. Felicia Bruel, Ange-Line Semplicio, Giuseppe Valsecchi, Claudia Isabelle Keller Aktaş, Tuğçe Duffourd, Yannis Rumpf, Tobias Morton, Jenny Bache, Iben Szymanski, Witold G.
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Published in
Nature Genetics
De novo mutations in MSL3 cause an X-linked syndrome affecting both males and females. MSL3 mutations reduce H4K16ac levels and lead to misregulation of cellular pathways involved in morphogenesis, cellular shape, and cell migration.
McInnes, Joseph Wierda, Keimpe Snellinx, An Bounti, Laura Wang, Yu-Chun Stancu, Ilie-Cosmin Apóstolo, Nuno Gevaert, Kris Dewachter, Ilse Spires-Jones, Tara L
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Published in
Neuron
Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may be therapeutically beneficial to prevent cognitive decline and disease progression, but the mechanisms underlying synaptic defects associated with Tau are unclear. In...
Kim, KT Heo, W Joo, T Kim, BH
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Baëza, Manon Viala, Séverine Heim, Marjorie Dard, Amélie Hudry, Bruno Duffraisse, Marilyne Rogulja-Ortmann, Ana Brun, Christine Merabet, Samir
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in t...
Wang, Fen Wang, Yanjie Ji, Junjie Zhou, Zhan Yu, Jingkai Zhu, Hua Su, Zhiguo Zhang, Lixin Zheng, Jianting
The loading acyltransferase (AT) domains of modular polyketide synthases (PKSs) control the choice of starter units incorporated into polyketides and are therefore attractive targets for the engineering of modular PKSs. Here, we report the structural and biochemical characterizations of the loading AT from avermectin modular PKS, which accepts more...
Palma, AS Liu, Y Zhang, H Zhang, Y McCleary, BV Yu, G Huang, Q Guidolin, LS Ciocchini, AE Torosantucci, A
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Vercruyssen, Liesbeth Tognetti, Vanesa Gonzalez Sanchez, Nathalie Van Dingenen, Judith De Milde, Liesbeth Bielach, Agnieszka De Rycke, Riet Van Breusegem, Frank Inzé, Dirk
Arabidopsis (Arabidopsis thaliana) leaf development relies on subsequent phases of cell proliferation and cell expansion. During the proliferation phase, chloroplasts need to divide extensively, and during the transition from cell proliferation to expansion, they differentiate into photosynthetically active chloroplasts, providing the plant with en...
Lepeltier, Elise Anne Nuhn, Lutz Lehr, Claus-Michael Zentel, Rudolf
Published in
Nanomedicine (London, England)
During the last 3 decades, nanomedicines have provided novel opportunities to improve the delivery of chemotherapeutics in cancer therapy effectively. However, many principles learnt from there have the potential to be transferred to other diseases. This perspective article, on the one hand, critically reflects the limitations of nanomedicines in t...
Puranik, Sriharsha Acajjaoui, Samira Conn, Simon Costa, Luca Conn, Vanessa Vial, Anthony Marcellin, Romain Melzer, Rainer Brown, Elizabeth Hart, Darren
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Published in
The Plant cell
In plants, MADS domain transcription factors act as central regulators of diverse developmental pathways. In Arabidopsis thaliana, one of the most central members of this family is SEPALLATA3 (SEP3), which is involved in many aspects of plant reproduction, including floral meristem and floral organ development. SEP3 has been shown to form homo and ...
sheng, ren kim, hyunjoon lee, hyeyoon xin, yao chen, yong tian, wen cui, yang choi, jong-cheol Doh, J Han, JK
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Wnt proteins control diverse biological processes through beta-catenin-dependent canonical signalling and beta-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the branch point o...