Oltra, Sara S. Peña-Chilet, Maria Vidal-Tomas, Victoria Flower, Kirsty Martinez, María Teresa Alonso, Elisa Burgues, Octavio Lluch, Ana Flanagan, James M. Ribas, Gloria
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Published in
Scientific Reports
MiRNAs are part of the epigenetic machinery, and are also epigenetically modified by DNA methylation. MiRNAs regulate expression of different genes, so any alteration in their methylation status may affect their expression. We aimed to identify methylation differences in miRNA encoding genes in breast cancer affecting women under 35 years old (BCVY...
Mechri, Meriem Riahi, Hend Sboui, Imed Bouaziz, Mouna Vanhoenacker, Filip Ladeb, Mohamed
Published in
Journal of the Belgian Society of Radiology
Primary malignant tumors of the spine are rare and mainly include chordoma, chondrosarcoma, Ewing sarcoma or primitive neuroectodermal tumor, and osteosarcoma. The final diagnosis is based on the combination of patient age, topographic and histologic features of the tumor, and lesion pattern on computed tomography (CT) and magnetic resonance (MR) i...
Potts, Jonathan R Farahi, Neda Howard, Mark R Taylor, Mark R Heard, Sarah Shankar, Arun N Alexander, Graeme J Chilvers, Edwin R Verma, Sumita Peters, A Michael
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Published in
Bioscience reports
The study's aim was to image severe alcoholic hepatitis (SAH) using 111In-labelled leucocytes with two objectives in mind: firstly for non-invasive diagnosis and secondly to provide a platform for experimental therapies aiming to inhibit intrahepatic neutrophil migration. 111In-leucocyte scintigraphy was performed 30 min and 24 h post-injection in ...
Kuriya, Bindee Joshi, Raman Movahedi, Mohammad Rampakakis, Emmanouil Sampalis, John S Bombardier, Claire
Published in
The Journal of rheumatology
We sought to determine if initial high disease activity or changes in disease activity contribute to persistent depression in early rheumatoid arthritis (ERA). We also determined if disease activity and depression is modified by sex. Depression was ascertained by self-report among patients enrolled in the Ontario Best Practices Research Initiative....
Mah, Douglas Y. Sleeper, Lynn A. Crosson, Jane E. Czosek, Richard J. Love, Barry A. McCrindle, Brian W. Muiño-Mosquera, Laura Olson, Aaron K. Pilcher, Thomas A. Tierney, Elif Seda Selamet
...
Published in
The American journal of cardiology
Individuals with the Marfan syndrome (MFS) are at risk for sudden death. The contribution of arrhythmias is unclear. This study examines the prevalence of arrhythmias in children with the MFS and their relationship to clinical/echocardiographic factors. Data from the Pediatric Heart Network randomized trial of atenolol vs. losartan in MFS were anal...
Decloedt, Annelies Broux, Barbara De Clercq, Dominique Deprez, Piet Van Steenkiste, Glenn Vera, Lisse Ven, Sofie van Loon, Gunther
Background: Based on its pharmacokinetic profile and electrophysiological effects in healthy horses, sotalol potentially could be used as a long-term PO antiarrhythmic drug in horses. Objectives: To evaluate the effect of sotalol on heart rate (HR), QT interval, atrial fibrillatory rate, and success of cardioversion in horses with naturally occurri...
Rivière, Sébastien Hua-Huy, Thong Tiev, Kiet Phong Cabane, Jean Dinh-Xuan, Anh Tuan
Published in
The Journal of rheumatology
Clara cell secretory protein (CC16) is a sensitive marker of bronchial epithelial cell damage. The CC16 serum level is elevated in patients with pulmonary fibrosis, but its predictive value on lung disease progression has not yet been studied. We aimed to assess the value of serum CC16 concentration in predicting lung disease deterioration in patie...
De Schreye, Robrecht Smets, Tinne Deliens, Luc Annemans, Lieven Gielen, Birgit Cohen, Joachim
Molina, Jean-Michel Grund, Birgit Gordin, Fred Williams, Ian Schechter, Mauro Losso, Marcello Law, Matthew Ekong, Ernest Mwelase, Noluthando Skoutelis, Athanasios
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Background: Immediate initiation of antiretroviral therapy (ART) in asymptomatic adults with CD4 counts higher than 500 cells per mu L, as recommended, might not always be possible in resource-limited settings. We aimed to identify subgroups of individuals who would benefit most from immediate treatment. Methods: The START trial was a randomised co...
Turner-Stokes, Tabitha Wilson, Hannah R Morreale, Massimiliano Nunes, Ana Cairns, Tom Cook, H Terence Pusey, Charles D Tarzi, Ruth M Lightstone, Liz
Published in
Kidney international
Class IV-S lupus nephritis is often associated with more necrosis and fewer subendothelial immune deposits compared to class IV-G lupus nephritis, suggestive of necrotising glomerular inflammation found in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. ANCAs are present in a significant proportion of patients with lupus nephritis...
