Many challenges of conducting clinical trials in CJD.
Published in Journal of neurology, neurosurgery, and psychiatry
Pharmacokinetics of intravenously and orally administered sotalol hydrochloride in horses and effects on surface electro...
Published in Veterinary journal (London, England : 1997)
Arrhythmias are common in horses. Some, such as frequent atrial or ventricular premature beats, may require long-term anti-arrhythmic therapy. In humans and small animals, sotalol hydrochloride (STL) is often used for chronic oral anti-arrhythmic therapy. STL prolongs repolarization and the effective refractory period in all cardiac tissues. No inf...
Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Au...
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The inexorable decline in the armament of registered chemical insecticides has stimulated research into environmentally-friendly alternatives. Insecticidal spider-venom peptides are promising candidates for bioinsecticide development but it is challenging to find peptides that are specific for targeted pests. In the present study, we isolated an in...
Bleeding events and maintenance dose of prasugrel: BLESS pilot study.
...Published in Open heart
To evaluate changes in residual platelet reactivity (RPR) over time, and bleeding and ischaemic events rate using 5 vs 10 mg maintenance dose (MD) regimens of prasugrel 1 month after acute coronary syndrome (ACS). The optimal level of RPR with prasugrel may change over time after an ACS. After 60 mg loading dose of prasugrel (T0) followed by 10 mg/...
Population pharmacokinetics of intravenous paracetamol (acetaminophen) in preterm and term neonates: model development a...
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OBJECTIVES: The aims of this study were to develop a population pharmacokinetic model for intravenous paracetamol in preterm and term neonates and to assess the generalizability of the model by testing its predictive performance in an external dataset. METHODS: Nonlinear mixed-effects models were constructed from paracetamol concentration-time data...
The relationship between infliximab concentrations, antibodies to infliximab and disease activity in Crohn's disease.
...Published in Gut
Although low infliximab trough concentrations and antibodies to infliximab (ATI) are associated with poor outcomes in patients with Crohn's disease (CD), the clinical relevance of ATI in patients with adequate infliximab concentrations is uncertain. We evaluated this question using an assay sensitive for identification of ATI in the presence of inf...
A multi-label approach to target prediction taking ligand promiscuity into account
Published in Journal of Cheminformatics
BackgroundAccording to Cobanoglu et al., it is now widely acknowledged that the single target paradigm (one protein/target, one disease, one drug) that has been the dominant premise in drug development in the recent past is untenable. More often than not, a drug-like compound (ligand) can be promiscuous – it can interact with more than one target p...
Republished: A straightforward guide to the basic science behind arrhythmogenesis.
Published in Postgraduate medical journal
The underlying mechanisms behind cardiac arrhythmias are described in this manuscript. In clinical practice, significant arrhythmias are unpredictable, and under some conditions, potentially life-threatening. How can basic science help improve our understanding of molecular entities and factors behind the arrhythmia to advance, develop, adapt or de...
What can we learn from RELAX-AHF compared to previous AHF trials and what does the future hold?
Published in Open heart
Each year in the USA there are over 1 million hospital admissions directly related to heart failure (HF). With similar rates across Europe, this places a huge economic burden on healthcare systems globally. Hospitalisation for HF is associated with poor clinical outcomes with 25% of patients being readmitted with signs and symptoms of HF within 1 m...
Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric ...
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The nicotinic acetylcholine receptor alpha 4 beta 2 is important for normal mammalian brain function and is known to express in two different stoichiometries, (alpha 4)(2)(beta 2)(3) and (alpha 4)(3)(beta 2)(2). While these are similar in many aspects, the (alpha 4)(3)(beta 2)(2) stoichiometry differs by harboring a third orthosteric acetylcholine ...
