Van Acker, Thibaut Buckle, Tessa Van Malderen, Stijn van Willigen, Danny M van Unen, Vincent van Leeuwen, Fijs WB Vanhaecke, Frank
This work evaluates the possibility of placement of high-resolution imaging and single-cell analysis via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) within precision medicine by assessing the suitability of LA-ICP-MS as a micro-analytical technique for the localization and quantification of membranous receptors in hetero...
Hillen, Lisa M; Geybels, Milan S; Rennspiess, Dorit; Spassova, Ivelina; Ritter, Cathrin; Becker, Juergen C; Garmyn, Marjan; 3474; zur Hausen, Axel; Van den Oord, Joost; 6854; Winnepenninckx, Veronique;
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The molecular properties of benign melanocytic lesions are poorly understood. Only a few studies have been carried out on specific nevi subtypes, including common nevocellular nevi (NCN) or Spitz nevi (SN). Genomic alterations in melanoma-associated oncogenes are typically absent in SN. In the present study, mRNA expressions of 25 SN and 15 NCN wer...
Ackerman, T. Geerts, A. Van Vlierberghe, H. De Backer, J. François, K.
Published in
Pediatric Cardiology
We tried to identify structural and functional liver aberrances in a palliated Fontan population and sought to determine useful screening modalities, in order to propose a screening protocol to detect patients at risk. Twenty nine patients, median age 23.7 years (interquartile range (IQR) 20.5–27.2) and median Fontan interval 19.7 years (IQR 4.5–21...
Tack, Veronique; 91526; Spans, Lien; 64303; Schuuring, Ed; Keppens, Cleo; 78871; Zwaenepoel, Karen; Pauwels, Patrick; Van Houdt, Jeroen; Dequeker, Elisabeth MC; 10260;
Because interpretation of next-generation sequencing (NGS) data remains challenging, optimization of the NGS process is needed to obtain correct sequencing results. Therefore, extensive validation and continuous monitoring of the quality is essential. NGS performance was compared with traditional detection methods and technical quality of nine NGS ...
Bevan, RJ Evans, R Griffiths, L Watkins, LM Rees, MI Magliozzi, R Allen, I McDonnell, G Kee, R Naughton, M
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Objective Cortical gray matter (GM) pathology, involving demyelination and neurodegeneration, associated with meningeal inflammation, could be important in determining disability progression in multiple sclerosis (MS). However, we need to know more about how cortical demyelination, neurodegeneration, and meningeal inflammation contribute to patholo...
Tack, Lloyd J.W. Maris, Ellen Looijenga, Leendert H.J. Hannema, Sabine E. Audi, Laura Köhler, Birgit Holterhus, Paul-Martin Riedl, Stefan Wisniewski, Amy Flück, Christa E.
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Published in
Hormone Research in Paediatrics
Background: Complete and partial androgen insensitivity syndrome (CAIS, PAIS) are associated with an increased risk of gonadal germ cell cancer (GGCC). Recent guidelines recommend gonadectomy in women with CAIS in late adolescence. Nevertheless, many adult women prefer to retain their gonads. Aims: This study aims to explore attitudes towards gonad...
Grant, Y Al-Khudairi, R St John, E Barschkett, M Cunningham, D Al-Mufti, R Hogben, K Thiruchelvam, P Hadjiminas, DJ Darzi, A
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Background High rates of reoperation following breast‐conserving surgery (BCS) for positive margins are associated with costs to healthcare providers. The aim was to assess the quality of evidence on reported re‐excision costs and compare the direct patient‐level costs between patients undergoing successful BCS versus reoperations after BCS. Method...
Thal, Dietmar Rudolf; 97737; Beach, Thomas G; Zanette, Michelle; Lilja, Johan; Heurling, Kerstin; Chakrabarty, Aruna; Ismail, Azzam; Farrar, Gill; Buckley, Christopher; Smith, Adrian PL;
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The deposition of the amyloid β-protein (Aβ) in senile plaques is one of the histopathological hallmarks of Alzheimer's disease (AD). Aβ-plaques arise first in neocortical areas and, then, expand into further brain regions in a process described by 5 phases. Since it is possible to identify amyloid pathology with radioactive-labeled tracers by posi...
Garcia-Leon, Juan Antonio; Cabrera-Socorro, Alfredo; Eggermont, Kristel; Swijsen, Ann; Terryn, Joke; 99114; Fazal, Raheem; 85196; Nami, FatemehArefeh; 97878; Ordovas, Laura; Quiles, Ana; Lluis, Frederic; 96752;
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INTRODUCTION: Tauopathies are neurodegenerative diseases characterized by TAU protein-related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but none of them faithfully recapitulates human pathology and are not suitable for drug screening. METHODS: To create a new in vitro ...
Redondo, Iratxe; Luyten, Patrick; 6541;
The objective of the study was to investigate whether mindfulness mediated the relationship between attachment and eating disorders in a sample of 323 female university students and 38 anorexic inpatients using structural equation modeling. All insecure attachment subscales were positively related to eating disorder symptoms and negatively to mindf...