Chen, Zhenzhen Claerebout, Edwin Chiers, Koen Pas, Mathilde Pardon, Bart van Mol, Wouter Casaert, Stijn De Wilde, Nathalie Duchateau, Luc Geldhof, Peter
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Published in
Veterinary Research
Psoroptic mange is a common disease of livestock, caused by Psoroptes ovis. Compared to Holstein–Friesian (HF) cattle, the Belgian Blue (BB) cattle breed is highly susceptible to the infestation. However, the mechanism for this difference is still unclear. To determine the factors responsible for this breed susceptibility, the immune response to P....
Menikou, S McArdle, AJ Li, M-S Kaforou, M Langford, PR Levin, M
A novel approach to recover and identify immune complexes (ICs) was developed using size exclusion chromatography (SEC) and affinity chromatography on immunoglobulin binding columns (HiTrap Protein G). The purification process was monitored by 1D SDS-PAGE, protein staining, Western blotting and, finally, liquid chromatography tandem mass spectromet...
Berlamont, Helena De Witte, Chloë Bauwens, Eva Min Jou, Hannah Ducatelle, Richard De Meester, Ellen Gansemans, Yannick Deforce, Dieter Van Nieuwerburgh, Filip Haesebrouck, Freddy
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Published in
Veterinary Research
The porcine Helicobacter suis and canine-feline H. heilmannii are gastric Helicobacter species with zoonotic potential. However, little is known about the pathogenesis of human infections with these Helicobacter species. To gain more insight into the interactions of both zoonotic Helicobacter species with human gastric epithelial cells, we investig...
Boudewijns, Robbert Thibaut, Hendrik Jan Kaptein, Suzanne J. F. Li, Rong Vergote, Valentijn Seldeslachts, Laura Van Weyenbergh, Johan De Keyzer, Carolien Bervoets, Lindsey Sharma, Sapna
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Published in
Nature Communications
SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection.
Munoz-Fontela, Cesar; Dowling, William E; Funnell, Simon GP; Gsell, Pierre-S; Riveros-Balta, A Ximena; Albrecht, Randy A; Andersen, Hanne; Baric, Ralph S; Carroll, Miles W; Cavaleri, Marco;
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has in...
Wu, Guanghao Wei, Wei Zhang, Jinfeng Nie, Weidong Yuan, Lan Huang, Yuanyu Zuo, Liping Huang, Lili Xi, Xiaobo Xie, Hai-Yan
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Atherosclerosis, as a silent killer, remains one of the most common causes of human morbidity and mortality worldwide due to the lack of efficient strategy for early detection and targeted therapy. In this work, a self-driven bioinspired nanovehicle is developed, which can accurately manage early atherosclerosis with simultaneously multiple-targeti...
Mortaz, E Tabarsi, P Varahram, M Folkerts, G Adcock, IM
Coronaviruses were first discovered in the 1960s and are named due to their crown-like shape. Sometimes, but not often, a coronavirus can infect both animals and humans. An acute respiratory disease, caused by a novel coronavirus (severe acute respiratory syndrome coronavirus-2 or SARS-CoV-2 previously known as 2019-nCoV) was identified as the caus...
Fahlbusch, Pia Knebel, Birgit Hörbelt, Tina Barbosa, David Monteiro Nikolic, Aleksandra Jacob, Sylvia Al-Hasani, Hadi Van de Velde, Frederique Van Nieuwenhove, Yves Müller-Wieland, Dirk
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Published in
International Journal of Molecular Sciences
Fatty liver occurs from simple steatosis with accumulated hepatic lipids and hepatic insulin resistance to severe steatohepatitis, with aggravated lipid accumulation and systemic insulin resistance, but this progression is still poorly understood. Analyses of hepatic gene expression patterns from alb-SREBP-1c mice with moderate, or aP2-SREBP-1c mic...
Cohen, EJ Nakane, D Kabata, Y Hendrixson, DR Nishizaka, T Beeby, M
Campylobacter jejuni rotates a flagellum at each pole to swim through the viscous mucosa of its hosts’ gastrointestinal tracts. Despite their importance for host colonization, however, how C. jejuni coordinates rotation of these two opposing flagella is unclear. As well as their polar placement, C. jejuni’s flagella deviate from the norm of Enterob...
El-Sherbiny, Yasser M Md Yusof, Md Yuzaiful Psarras, Antonios Hensor, Elizabeth M A Kabba, Kumba Z Dutton, Katherine Mohamed, Alaa A A Elewaut, Dirk McGonagle, Dennis Tooze, Reuben
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Published in
Arthritis & rheumatology (Hoboken, N.J.)
Type I interferon (IFN) responses are broadly associated with autoimmune diseases, including systemic lupus erythematosus (SLE). Given the cardinal role of autoantibodies in SLE, this study was undertaken to investigate whether the findings of a B cell-specific IFN assay correlate with SLE activity. B cells and peripheral blood mononuclear cells (P...
