Chen, Zhenzhen Claerebout, Edwin Chiers, Koen Pas, Mathilde Pardon, Bart van Mol, Wouter Casaert, Stijn De Wilde, Nathalie Duchateau, Luc Geldhof, Peter
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Published in
Veterinary Research
Psoroptic mange is a common disease of livestock, caused by Psoroptes ovis. Compared to Holstein–Friesian (HF) cattle, the Belgian Blue (BB) cattle breed is highly susceptible to the infestation. However, the mechanism for this difference is still unclear. To determine the factors responsible for this breed susceptibility, the immune response to P....
Van Loo, H. Pascottini, osvaldo Ribbens, S. Hooyberghs, J. Pardon, B. Opsomer, G.
Abortion and perinatal mortality, leading causes of economic loss in cattle industry, are the consequence of both non-infectious and a wide range of infectious causes. However, the relative contribution of pathogens to bovine abortion and perinatal mortality is poorly documented, since available studies involved only a limited number of pathogens. ...
Menikou, S McArdle, AJ Li, M-S Kaforou, M Langford, PR Levin, M
A novel approach to recover and identify immune complexes (ICs) was developed using size exclusion chromatography (SEC) and affinity chromatography on immunoglobulin binding columns (HiTrap Protein G). The purification process was monitored by 1D SDS-PAGE, protein staining, Western blotting and, finally, liquid chromatography tandem mass spectromet...
Berlamont, Helena De Witte, Chloë Bauwens, Eva Min Jou, Hannah Ducatelle, Richard De Meester, Ellen Gansemans, Yannick Deforce, Dieter Van Nieuwerburgh, Filip Haesebrouck, Freddy
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Published in
Veterinary Research
The porcine Helicobacter suis and canine-feline H. heilmannii are gastric Helicobacter species with zoonotic potential. However, little is known about the pathogenesis of human infections with these Helicobacter species. To gain more insight into the interactions of both zoonotic Helicobacter species with human gastric epithelial cells, we investig...
Boudewijns, Robbert Thibaut, Hendrik Jan Kaptein, Suzanne J. F. Li, Rong Vergote, Valentijn Seldeslachts, Laura Van Weyenbergh, Johan De Keyzer, Carolien Bervoets, Lindsey Sharma, Sapna
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Published in
Nature Communications
SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection.
Goossens, E Dierick, E Ducatelle, R Van Immerseel, F
Published in
Avian pathology : journal of the W.V.P.A
Necrotic enteritis (NE) is one of the most detrimental infectious diseases in the modern poultry industry, characterized by necrosis in the small intestine. It is commonly accepted that NetB-producing C. perfringens type G strains are responsible for the disease. However, based on both macroscopic and histopathological observations, two distinct ty...
Goossens, Evy Van Erum, Johan De Gussem, Maarten Van Limbergen, Tommy Callens, Chana De Zutter, Lieven Ducatelle, Richard Van Immerseel, Filip
Published in
Avian pathology : journal of the W.V.P.A
Necrotic enteritis (NE) caused by Clostridium perfringens is commonly reported in broilers. Recently, increased NE prevalence in layer breeds was reported in the Indian subcontinent. NE is also frequently observed by veterinary practitioners in Europe, mainly during the pullet rearing phase. In this study, data from layer pullet flocks in Belgium o...
Munoz-Fontela, Cesar; Dowling, William E; Funnell, Simon GP; Gsell, Pierre-S; Riveros-Balta, A Ximena; Albrecht, Randy A; Andersen, Hanne; Baric, Ralph S; Carroll, Miles W; Cavaleri, Marco;
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has in...
Boland, Brigid S; He, Zhaoren; Tsai, Matthew S; Olvera, Jocelyn G; Omilusik, Kyla D; Duong, Han G; Kim, Eleanor S; Limary, Abigail E; Jin, Wenhao; Milner, J Justin;
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Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders driven by dysregulated immune responses against gut microbiota. We integrated single-cell RNA and antigen receptor sequencing to elucidate key components, cellular states, and clonal relationships of the peripheral and gastrointestinal mucosal immune systems in he...
Wu, Guanghao Wei, Wei Zhang, Jinfeng Nie, Weidong Yuan, Lan Huang, Yuanyu Zuo, Liping Huang, Lili Xi, Xiaobo Xie, Hai-Yan
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Atherosclerosis, as a silent killer, remains one of the most common causes of human morbidity and mortality worldwide due to the lack of efficient strategy for early detection and targeted therapy. In this work, a self-driven bioinspired nanovehicle is developed, which can accurately manage early atherosclerosis with simultaneously multiple-targeti...
