Berlamont, Helena De Witte, Chloë Bauwens, Eva Min Jou, Hannah Ducatelle, Richard De Meester, Ellen Gansemans, Yannick Deforce, Dieter Van Nieuwerburgh, Filip Haesebrouck, Freddy
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Published in
Veterinary Research
The porcine Helicobacter suis and canine-feline H. heilmannii are gastric Helicobacter species with zoonotic potential. However, little is known about the pathogenesis of human infections with these Helicobacter species. To gain more insight into the interactions of both zoonotic Helicobacter species with human gastric epithelial cells, we investig...
Wu, Guanghao Wei, Wei Zhang, Jinfeng Nie, Weidong Yuan, Lan Huang, Yuanyu Zuo, Liping Huang, Lili Xi, Xiaobo Xie, Hai-Yan
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Atherosclerosis, as a silent killer, remains one of the most common causes of human morbidity and mortality worldwide due to the lack of efficient strategy for early detection and targeted therapy. In this work, a self-driven bioinspired nanovehicle is developed, which can accurately manage early atherosclerosis with simultaneously multiple-targeti...
Cohen, EJ Nakane, D Kabata, Y Hendrixson, DR Nishizaka, T Beeby, M
Campylobacter jejuni rotates a flagellum at each pole to swim through the viscous mucosa of its hosts’ gastrointestinal tracts. Despite their importance for host colonization, however, how C. jejuni coordinates rotation of these two opposing flagella is unclear. As well as their polar placement, C. jejuni’s flagella deviate from the norm of Enterob...
El-Sherbiny, Yasser M Md Yusof, Md Yuzaiful Psarras, Antonios Hensor, Elizabeth M A Kabba, Kumba Z Dutton, Katherine Mohamed, Alaa A A Elewaut, Dirk McGonagle, Dennis Tooze, Reuben
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Published in
Arthritis & rheumatology (Hoboken, N.J.)
Type I interferon (IFN) responses are broadly associated with autoimmune diseases, including systemic lupus erythematosus (SLE). Given the cardinal role of autoantibodies in SLE, this study was undertaken to investigate whether the findings of a B cell-specific IFN assay correlate with SLE activity. B cells and peripheral blood mononuclear cells (P...
Aslanidou, Lydia Ferraro, Mauro Lovric, Goran Bersi, Matthew R Humphrey, Jay D Segers, Patrick Trachet, Bram Stergiopulos, Nikos
Published in
Biomechanics and modeling in mechanobiology
Animal models of aortic aneurysm and dissection can enhance our limited understanding of the etiology of these lethal conditions particularly because early-stage longitudinal data are scant in humans. Yet, the pathogenesis of often-studied mouse models and the potential contribution of aortic biomechanics therein remain elusive. In this work, we co...
Van Nuffel, Elien Staal, Jens Baudelet, Griet Haegman, Mira Driege, Yasmine Hochepied, Tino Afonina, Inna Beyaert, Rudi
CARD14 gain-of-function mutations cause psoriasis in humans and mice. Together with BCL10 and the protease MALT1, mutant CARD14 forms a signaling node that mediates increased NF-κB signaling and proinflammatory gene expression in keratinocytes. However, it remains unclear whether psoriasis in response to CARD14 hyperactivation is keratinocyte-intri...
Goossens, Evy Dierick, Evelien Ducatelle, Richard Van Immerseel, Filip
Necrotic enteritis (NE) is one of the most detrimental infectious diseases in the modern poultry industry, characterized by necrosis in the small intestine. It is commonly accepted that NetB-producing C. perfringens type G strains are responsible for the disease. However, based on both macroscopic and histopathological observations, two distinct ty...
Raevens, Sarah Van Campenhout, Sanne Debacker, Pieter-Jan Lefere, Sander Verhelst, Xavier Geerts, Anja Van Vlierberghe, Hans Colle, Isabelle Devisscher, Lindsey
Hepatocyte death during acetaminophen (APAP) intoxication elicits a reactive inflammatory response, with hepatic recruitment of neutrophils and monocytes, which further aggravates liver injury. Neutrophil elastase (NE), secreted by activated neutrophils, carries degradative and cytotoxic functions and maintains a proinflammatory state. We investiga...
Goossens, Evy Van Erum, Johan De Gussem, Maarten Van Limbergen, Tommy Callens, Chana De Zutter, Lieven Ducatelle, Richard Van Immerseel, Filip
Necrotic enteritis (NE) caused byClostridium perfringensis commonly reported in broilers. Recently, increased NE prevalence in layer breeds was reported in the Indian subcontinent. NE is also frequently observed by veterinary practitioners in Europe, mainly during the pullet rearing phase. In this study, data from layer pullet flocks in Belgium ove...
Bergmann, Wilhelmina de Mik-van Mourik, Marjolijn Veraa, Stefanie van den Broek, Jan Wijnberg, Inge D. Back, Willem Grone, Andrea
Background In Warmblood horses, degenerative joint disease is involved in cervical malformation and malarticulation (CVM). The degree of contribution of articular process joint (APJ) osteochondrosis (OC) is not clear. Objectives (a) To explore the presence of predilection sites for APJ OC in cervical and cranial thoracic vertebral columns of Warmbl...
