Dourine, caused by Trypanosoma equiperdum, is a life-threatening venereal disease in equidae. So far, there is no clear evidence on how and when stallions become infectious, nor which tissues are affected by the parasite in diseased animals. Post-infection, after a transient, temporary phase of parasitaemia, the parasite disperses to different tiss...
Outcome of host-pathogen encounter is determined by the complex interplay between protective bacterial and host defense strategies. This complexity further amplifies with the existence of cell-to-cell phenotypic heterogeneity in pathogens which remains largely unexplored. In this study, we illustrated that heterogeneous expression of pneumolysin (P...
Outcome of host-pathogen encounter is determined by the complex interplay between protective bacterial and host defense strategies. This complexity further amplifies with the existence of cell-to-cell phenotypic heterogeneity in pathogens which remains largely unexplored. In this study, we illustrated that heterogeneous expression of pneumolysin (P...
The involvement of alpha-synuclein (alpha-Syn) amyloid formation in Parkinson's disease (PD) pathogenesis is supported by the discovery of alpha-Syn gene (SNCA) mutations linked with familial PD, which are known to modulate the oligomerization and aggregation of a-Syn. Recently, the A53V mutation has been discovered, which leads to late-onset PD. I...
The involvement of alpha-synuclein (alpha-Syn) amyloid formation in Parkinson's disease (PD) pathogenesis is supported by the discovery of alpha-Syn gene (SNCA) mutations linked with familial PD, which are known to modulate the oligomerization and aggregation of a-Syn. Recently, the A53V mutation has been discovered, which leads to late-onset PD. I...
The involvement of alpha-synuclein (alpha-Syn) amyloid formation in Parkinson's disease (PD) pathogenesis is supported by the discovery of alpha-Syn gene (SNCA) mutations linked with familial PD, which are known to modulate the oligomerization and aggregation of a-Syn. Recently, the A53V mutation has been discovered, which leads to late-onset PD. I...
Outcome of host-pathogen encounter is determined by the complex interplay between protective bacterial and host defense strategies. This complexity further amplifies with the existence of cell-to-cell phenotypic heterogeneity in pathogens which remains largely unexplored. In this study, we illustrated that heterogeneous expression of pneumolysin (P...
The involvement of alpha-synuclein (alpha-Syn) amyloid formation in Parkinson's disease (PD) pathogenesis is supported by the discovery of alpha-Syn gene (SNCA) mutations linked with familial PD, which are known to modulate the oligomerization and aggregation of a-Syn. Recently, the A53V mutation has been discovered, which leads to late-onset PD. I...
Outcome of host-pathogen encounter is determined by the complex interplay between protective bacterial and host defense strategies. This complexity further amplifies with the existence of cell-to-cell phenotypic heterogeneity in pathogens which remains largely unexplored. In this study, we illustrated that heterogeneous expression of pneumolysin (P...
To investigate coronal plane trunk asymmetry (TA) and its association with sagittal postural alignment in healthy subjects before pubertal peak growth. In this cross-sectional baseline study, 1190 healthy pre-peak growth velocity subjects were included. Coronal plane TA was evaluated using back surface topography. Whole-body sagittal alignment (pre...
